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Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging

Sepe, Sara, Nardacci, Roberta, Fanelli, Francesca, Rosso, Pamela, Bernardi, Cinzia, Cecconi, Francesco, Mastroberardino, Pier G., Piacentini, Mauro, Moreno, Sandra·2014·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2013.07.001
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Abstract

Autophagy is a major protein degradation pathway, essential for stress-induced and constitutive protein turnover. In nervous tissue, autophagy is constitutively active and crucial to neuronal survival. The efficiency of the autophagic pathway reportedly undergoes age-related decline, and autophagy defects are observed in neurodegenerative diseases. Since Ambra1 plays a fundamental role in regulating the autophagic process in developing nervous tissue, we investigated the expression of this protein in mature mouse brain and during physiological and Alzheimer type aging. The present study accomplished the first complete map of Ambra1 protein distribution in the various brain areas, and highlights differential expression in neuronal/glial cell populations. Differences in Ambra1 content are possibly related to specific neuronal features and properties, particularly concerning susceptibility to neurodegeneration. Furthermore, the analysis of Ambra1 expression in physiological and pathological brain aging supports important, though conflicting, functions of autophagy in neurodegenerative processes. Thus, novel therapeutic approaches, based on autophagy modulation, should also take into account the age-dependent roles of this mechanism in establishing, promoting, or counteracting neurodegeneration.

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Metadata

Authors
Sepe, S., Nardacci, R., Fanelli, F., Rosso, P., Bernardi, C., Cecconi, F., Mastroberardino, P. G., Piacentini, M., & Moreno, S.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2014-01
Volume
35
Issue
1
Pages
96-108
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2013.07.001
Cited by
41
References
7
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Telethon Foundation (GGP10225)
  • Italian Ministry of University and Research
  • Italian Ministry of Health
  • AIRC

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