Tauopathy with paired helical filaments in an aged chimpanzee
Open accessAbstract
An enigmatic feature of age‐related neurodegenerative diseases is that they seldom, if ever, are fully manifested in nonhuman species under natural conditions. The neurodegenerative tauopathies are typified by the intracellular aggregation of hyperphosphorylated microtubule‐associated protein tau (MAPT) and the dysfunction and death of affected neurons. We document the first case of tauopathy with paired helical filaments in an aged chimpanzee (Pan troglodytes). Pathologic forms of tau in neuronal somata, neuropil threads, and plaque‐like clusters of neurites were histologically identified throughout the neocortex and, to a lesser degree, in allocortical and subcortical structures. Ultrastructurally, the neurofibrillary tangles consisted of tau‐immunoreactive paired helical filaments with a diameter and helical periodicity indistinguishable from those seen in Alzheimer's disease. A moderate degree of Aβ deposition was present in the cerebral vasculature and, less frequently, in senile plaques. Sequencing of the exons and flanking intronic regions in the genomic MAPT locus disclosed no mutations that are associated with the known human hereditary tauopathies, nor any polymorphisms of obvious functional significance. Although the lesion profile in this chimpanzee differed somewhat from that in Alzheimer's disease, the copresence of paired helical filaments and Aβ‐amyloidosis indicates that the molecular mechanisms for the pathogenesis of the two canonical Alzheimer lesions—neurofibrillary tangles and senile plaques—are present in aged chimpanzees. J. Comp. Neurol. 509:259–270, 2008. © 2008 Wiley‐Liss, Inc.
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Great apes accumulate Aβ in the brain, resulting in the development of amyloid plaques and CAA in aged animals.
“Great apes accumulate Aβ in the brain, resulting in the development of amyloid plaques and CAA in aged animals [43, 44, 78, 112, 113, 124].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [124]
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- Authors
- Rosen, R. F., Farberg, A. S., Gearing, M., Dooyema, J., M. Long, P., Anderson, D. C., Davis‐Turak, J., Coppola, G., Geschwind, D. H., Paré, J., Duong, T. Q., Hopkins, W. D., Preuss, T. M., & Walker, L. C.
- Affiliations
- Emory University (US)
- University of California, Los Angeles (US)
- Corresponding author
- Walker, Lary C.
- ORCID
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2008-05-14
- Volume
- 509
- Issue
- 3
- Pages
- 259-270
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- PMC
- PMC2573460
- OpenAlex
- W2122920449
- Cited by
- 153
- References
- 74
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 10 · 2023: 13 · 2022: 4 · 2021: 14 · 2020: 5 · 2019: 3 · 2018: 11 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 12 · 2012: 6
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Yerkes National Primate Research Center, Emory University
- National Institute on Aging (P01AG026423, P50AG025688)
- National Institute of Neurological Disorders and Stroke (R01NS045879)
- National Center for Research Resources (RR-00 165, P51RR000165)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tauopathy, paired helical filaments, chimpanzees, neurofibrillary tangles, Alzheimer's disease, amyloid-beta deposition, amyloid plaques, MAPT, hyperphosphorylated tau, age-related neurodegeneration, nonhuman primate model, neocortex, neuropil threads
- MeSH terms
- Animals, Brain, Pan troglodytes, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunohistochemistry, Blotting, Western, Amyloid beta-Peptides, Neurofibrillary Tangles, tau Proteins, Neuropil Threads, Stroke, Tauopathies, Microscopy, Electron, Transmission, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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