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Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer's disease pathogenesis in the brain during peripheral chronic inflammation
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LRP1 has been implicated in AD pathology.
“has also been implicated in AD pathology. 21 , 32 , 33”
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APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
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Synapses and Alzheimer's Disease
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Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease
Marais, A. D. (2019) · Pathology · doi:10.1016/j.pathol.2018.11.002 · Cited by 382
Shinohara, M., Tachibana, M., Kanekiyo, T., & Bu, G. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r075796 · Cited by 297
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Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1
Kanekiyo, T., Cirrito, J. R., Liu, C.-C., Shinohara, M., Li, J., Schuler, D. R., Shinohara, M., Holtzman, D. M., & Bu, G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3487-13.2013 · Cited by 280
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Self-citationApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age
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Cited by
Sorted by citations
Hovde, M. J., Maaser‐Hecker, A., Bae, J., & Tanzi, R. E. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70879 · Cited by 8
Metadata
- Authors
- Na, H., Yang, J. B., Zhang, Z., Gan, Q., Tian, H., Rajab, I. M., Potempa, L. A., Tao, Q., & Qiu, W. Q.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 127
- Pages
- 54-69
- ISSN
- 0197-4580
- Cited by
- 27
- References
- 14
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 287 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- Boston University
- NIH
- National Institute on Aging (AG-008122, AG-022476, AG-16495)
- National Heart, Lung, and Blood Institute (N01-HC-25195)
- National Institute of Neurological Disorders and Stroke (NS-17950)
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