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LRP1 modulates the microglial immune response via regulation of JNK and NF‐ΚB signaling pathways
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LRP1 plays roles in lipid metabolism, protein clearance, and cell signaling.
“LRP1, a well‐known receptor playing roles in lipid metabolism, 28 protein clearance, 29 and cell signaling, 30 , 31”
Microglia express LRP1, which regulates multiple microglial activities including phagocytosis, inflammation and pathology.
“Microglia express LRP1, which regulates multiple microglial activities, including phagocytosis, inflammation and pathology (16, 17).”
From LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation (2023) · cites this paper as [17]
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Cites
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Self-citationThe reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
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“Interestingly, the cytoplasmic domain of LRP1 (LRP1-ICD) binds JNK-interacting proteins (JIP-1 and JIP-2), which have been identified as modulators of the JNK signal transduction pathway [53].”
BackgroundTREM2 in CNS homeostasis and neurodegenerative disease
Painter, M. M., Atagi, Y., Liu, C.-C., Rademakers, R., Xu, H., Fryer, J. D., & Bu, G. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0040-9 · Cited by 169
Self-citationGenetics ignite focus on microglial inflammation in Alzheimer’s disease
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Self-citationTREM2 is associated with increased risk for Alzheimer’s disease in African Americans
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Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures
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Metadata
- Authors
- Yang, L., Liu, C.-C., Zheng, H., Kanekiyo, T., Atagi, Y., Jia, L., Wang, D., N’songo, A., Can, D., Xu, H., Chen, X.-F., & Bu, G.
- Venue
- Journal of Neuroinflammation
- Published
- 2016-12
- Volume
- 13
- Issue
- 1
- ISSN
- 1742-2094
- PMC
- PMC5146875
- Cited by
- 129
- References
- 19
- Language
- en
- Funders
- National Institutes of Health (P01AG030128, P01NS074969)
- Cure Alzheimer’s Fundation
- National Natural Science Foundation of China (81370459, 31400914)
- Fundamental Research Funds for the Central Universities (20720150051)
- Guangdong Natural Science Foundation (2016A030306005)
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