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Functional-anatomic correlates of remembering and knowing
Abstract
Neural correlates of remembering were examined using event-related functional MRI (fMRI) in 20 young adults. A recognition paradigm based on the remember/know (RK) procedure was used to separately classify studied items that were correctly identified and accompanied by a conscious recollection of details about the study episode from studied items that were correctly identified in the absence of conscious recollection. To facilitate exploration of the basis of remember decisions, studied items were paired with pictures and sounds to encourage retrieval of specific content during scanned testing. Analyses using a priori regions of interest indicated that remembering recruited both regions that associate with the perception and/or decision that information is old and regions that associate preferentially with visual content, while knowing recruited regions associated with oldness, but did not recruit visual content regions. Exploratory analyses further indicated a functional dissociation across regions of parietal cortex that may aid to reconcile several divergent results in the literature. Lateral parietal regions responded preferentially to remember decisions, while a slightly medial region responded robustly to both remember and know decisions. Taken collectively, these results suggest that remembering and knowing associate with common processes supporting a perception and/or the decision that information is old. Remembering additionally recruits regions specific to retrieved content, which may participate to convey the vividness typical of recollective experience.
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“Activations in the posterior parietal cortex during retrieval have been correlated with the vividness (Wheeler and Buckner, 2004) and confidence (Kim and Cabeza, 2007) of recalled memories.”
From Neural Correlates of Long-Term Memory Enhancement Following Retrieval Practice (2021) · cites this paper as Wheeler and Buckner, 2004
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Metadata
- Authors
- Wheeler, M. E., & Buckner, R. L.
- Affiliations
- Washington University in St. Louis (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Wheeler, Mark E
- ORCID
- Buckner, Randy L
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 21
- Issue
- 4
- Pages
- 1337-1349
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2017869626
- Cited by
- 434
- References
- 110
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 12 · 2020: 4 · 2019: 10 · 2018: 7 · 2017: 25 · 2016: 15 · 2015: 19 · 2014: 24 · 2013: 24 · 2012: 34
- FWCI
- 16.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5r01mh057506-05)
- National Institute of Mental Health (MH 57506)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- remembering, knowing, recollection, recognition memory, remember/know procedure, neural correlates of memory, parietal cortex, memory vividness, conscious recollection
- MeSH terms
- Adult, Association Learning, Auditory Perception, Brain Mapping, Cerebral Cortex, Decision Making, Dominance, Cerebral, Evoked Potentials, Female, Humans, Image Enhancement, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Processes, Oxygen, Parietal Lobe, Pattern Recognition, Visual, Psychomotor Performance, Reaction Time, Mental Recall, Reference Values, Temporal Lobe, Verbal Learning, Imaging, Three-Dimensional, Recognition, Psychology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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