Comparing connectomes across subjects and populations at different scales
Open accessAbstract
Brain connectivity can be represented by a network that enables the comparison of the different patterns of structural and functional connectivity among individuals. In the literature, two levels of statistical analysis have been considered in comparing brain connectivity across groups and subjects: 1) the global comparison where a single measure that summarizes the information of each brain is used in a statistical test; 2) the local analysis where a single test is performed either for each node/connection which implies a multiplicity correction, or for each group of nodes/connections where each subset is summarized by one single test in order to reduce the number of tests to avoid a penalizing multiplicity correction. We comment on the different levels of analysis and present some methods that have been proposed at each scale. We highlight as well the possible factors that could influence the statistical results and the questions that have to be addressed in such an analysis.
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- Authors
- Meskaldji, D. E., Fischi-Gomez, E., Griffa, A., Hagmann, P., Morgenthaler, S., & Thiran, J.-P.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Meskaldji, Djalel Eddine
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 80
- Pages
- 416-425
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2019672444
- Cited by
- 77
- References
- 115
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 13 · 2017: 2 · 2016: 7 · 2015: 13 · 2014: 8 · 2013: 7
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- FNS (200020_14467, 320030_130090)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Complex Network Analysis Techniques
- Keywords
- brain connectome, structural connectivity, functional connectivity, cross-population comparison, multiplicity adjustment
- MeSH terms
- Animals, Brain, Data Interpretation, Statistical, Humans, Models, Anatomic, Models, Neurological, Nerve Net, Models, Statistical, Connectome
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