Voluntary control of anterior insula and its functional connections is feedback-independent and increases pain empathy
Abstract
Real-time functional magnetic resonance imaging (rtfMRI)-assisted neurofeedback (NF) training allows subjects to acquire volitional control over regional brain activity. Emerging evidence suggests its potential clinical utility as an effective non-invasive treatment approach in mental disorders. The therapeutic potential of rtfMRI-NF training depends critically upon whether: (1) acquired self-regulation produces functionally relevant changes at behavioral and brain network levels and (2) training effects can be maintained in the absence of feedback. To address these key questions, the present study combined rtfMRI-NF training for acquiring volitional anterior insula (AI) regulation with a sham-controlled between-subject design. The functional relevance of acquired AI control was assessed using both behavioral (pain empathy) and neural (activity, functional connectivity) indices. Maintenance of training effects in the absence of feedback was assessed two days later. During successful acquisition of volitional AI up-regulation subjects exhibited stronger empathic responses, increased AI-prefrontal coupling in circuits involved in learning and emotion regulation and increased resting state connectivity within AI-centered empathy networks. At follow-up both self-regulation and increased connectivity in empathy networks were fully maintained, although without further increases in empathy ratings. Overall these findings support the potential clinical application of rtfMRI-NF for inducing functionally relevant and lasting changes in emotional brain circuitry.
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Transfer of acquired strategies to everyday life and perceived efficiency have not been systematically examined in PTSD.
“Moreover, despite increasing evidence for the maintenance of neural regulatory control acquired during NF trainings in the absence of feedback and for periods of several days (Rance et al., 2018, Yao et al., 2016, Zhao et al., 2019) the transfer of the acquired strategies to everyday life and the perceived efficiency have not been systematically examined in PTSD.”
From Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder (2020) · cites this paper as Yao et al., 2016
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- Authors
- Yao, S., Becker, B., Geng, Y., Zhao, Z., Xu, X., Zhao, W., Ren, P., & Kendrick, K. M.
- Affiliations
- University of Electronic Science and Technology of China (CN)
- University of Bonn (DE)
- Corresponding author
- Kendrick, Keith M.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 130
- Pages
- 230-240
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2279193371
- Cited by
- 75
- References
- 80
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 12 · 2021: 6 · 2020: 10 · 2019: 9 · 2018: 8 · 2017: 4 · 2016: 1
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31530032)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- anterior insula, empathy for pain, voluntary self-regulation, functional connectivity, resting-state functional connectivity, emotion regulation
- MeSH terms
- Cerebral Cortex, Empathy, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Pain, Young Adult, Neurofeedback
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