Cited by 377Neurobiology of Language and BilingualismNeurological disorders and treatmentsFunctional Brain Connectivity Studies

Probabilistic map of critical functional regions of the human cerebral cortex: Broca’s area revisited

Tate, Matthew C., Herbet, Guillaume, Moritz-Gasser, Sylvie, Tate, Joseph E., Duffau, Hugues·2014·Brain

Abstract

The organization of basic functions of the human brain, particularly in the right hemisphere, remains poorly understood. Recent advances in functional neuroimaging have improved our understanding of cortical organization but do not allow for direct interrogation or determination of essential (versus participatory) cortical regions. Direct cortical stimulation represents a unique opportunity to provide novel insights into the functional distribution of critical epicentres. Direct cortical stimulation (bipolar, 60 Hz, 1-ms pulse) was performed in 165 consecutive patients undergoing awake mapping for resection of low-grade gliomas. Tasks included motor, sensory, counting, and picture naming. Stimulation sites eliciting positive (sensory/motor) or negative (speech arrest, dysarthria, anomia, phonological and semantic paraphasias) findings were recorded and mapped onto a standard Montreal Neurological Institute brain atlas. Montreal Neurological Institute-space functional data were subjected to cluster analysis algorithms (K-means, partition around medioids, hierarchical Ward) to elucidate crucial network epicentres. Sensorimotor function was observed in the pre/post-central gyri as expected. Articulation epicentres were also found within the pre/post-central gyri. However, speech arrest localized to ventral premotor cortex, not the classical Broca's area. Anomia/paraphasia data demonstrated foci not only within classical Wernicke's area but also within the middle and inferior frontal gyri. We report the first bilateral probabilistic map for crucial cortical epicentres of human brain functions in the right and left hemispheres, including sensory, motor, and language (speech, articulation, phonology and semantics). These data challenge classical theories of brain organization (e.g. Broca's area as speech output region) and provide a distributed framework for future studies of neural networks.

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Registry

Crossref · 10.1093/brain/awu168

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35 of 35 references verified0 citation errors · 0 not checkable

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  • The absence of production-related neural activity in area 44 is consistent with some recent work questioning the traditional role of Broca's area in speech.

    “The absence of production-related neural activity in area 44 is consistent with some recent work questioning the traditional role of Broca’s area in speech15–18.”

    From A high-performance speech neuroprosthesis (2023) · cites this paper as [15]

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Authors
Tate, M. C., Herbet, G., Moritz-Gasser, S., Tate, J. E., & Duffau, H.
Affiliations
  • Northwestern University (US)
  • Inserm (FR)
  • University of Toronto (CA)
Venue
Brain
Published
2014-06-25
Volume
137
Issue
10
Pages
2773-2782
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
OpenAlex
W2117808460
Cited by
377
References
35
Citations by year
2026: 18 · 2025: 31 · 2024: 28 · 2023: 29 · 2022: 31 · 2021: 37 · 2020: 42 · 2019: 25 · 2018: 33 · 2017: 37 · 2016: 37 · 2015: 20 · 2014: 8
FWCI
18.93
Type
journal article
Language
en
Open access
closed
Locations
  • Brain (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
Broca's area, Wernicke's area, direct cortical stimulation, language lateralization, right hemisphere language, speech arrest, anomia, paraphasia, ventral premotor cortex, inferior frontal gyrus, sensorimotor cortex
MeSH terms
Adult, Algorithms, Anomia, Brain, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Craniotomy, Electric Stimulation, Female, Frontal Lobe, Glioma, Humans, Functional Laterality, Male, Middle Aged, Nerve Net, Psychomotor Performance, Semantics, Speech, Speech Intelligibility, Models, Statistical, Cluster Analysis

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