Cited by 354Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

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Ensemble Dynamics of Hippocampal Regions CA3 and CA1

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Guzowski, John F., Knierim, James J., Moser, Edvard I.·2004·Neuron

DOI 10.1016/j.neuron.2004.11.003

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Abstract

Computational models based on hippocampal connectivity have proposed that CA3 is uniquely positioned as an autoassociative memory network, capable of performing the competing functions of pattern completion and pattern separation. Recently, three independent studies, two using parallel neurophysiological recording methods and one using immediate-early gene imaging, have examined the responses of CA3 and CA1 ensembles to alterations of environmental context in rats. The results provide converging evidence that CA3 is capable of performing nonlinear transformations of sensory input patterns, whereas CA1 may represent changes in input in a more linear fashion.

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Authors: Guzowski, J. F., Knierim, J. J., & Moser, E. I.
Affiliations: University of New Mexico (US)
The University of Texas Health Science Center at Houston (US)
Norwegian University of Science and Technology (NO)
Corresponding author: Guzowski, John F.
Knierim, James J.
Moser, Edvard I.
ORCID: Knierim, James J.
Moser, Edvard I.
Venue: Neuron
Publisher: Elsevier BV
Published: 2004-11
Volume: 44
Issue: 4
Pages: 581-584
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2004.11.003
OpenAlex: W1983540839
Cited by: 354
References: 21
Citations by year: 2026: 11 · 2025: 12 · 2024: 17 · 2023: 17 · 2022: 12 · 2021: 21 · 2020: 14 · 2019: 15 · 2018: 23 · 2017: 19 · 2016: 16 · 2015: 15 · 2014: 22 · 2013: 19 · 2012: 15
FWCI: 8.24
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3180 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: hippocampus, CA3, CA1, ensemble coding, pattern completion, pattern separation, autoassociative memory, environmental context, nonlinear transformation, sensory input, immediate early genes, hippocampal connectivity
MeSH terms: Animals, Hippocampus, Humans, Memory, Models, Neurological, Neural Pathways, Pattern Recognition, Physiological

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Ensemble Dynamics of Hippocampal Regions CA3 and CA1

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