CA1 and CA3 differentially support spontaneous retrieval of episodic contexts within human hippocampal subfields
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Abstract
The hippocampus plays a critical role in spatial and episodic memory. Mechanistic models predict that hippocampal subfields have computational specializations that differentially support memory. However, there is little empirical evidence suggesting differences between the subfields, particularly in humans. To clarify how hippocampal subfields support human spatial and episodic memory, we developed a virtual reality paradigm where participants passively navigated through houses (spatial contexts) across a series of videos (episodic contexts). We then used multivariate analyses of high-resolution fMRI data to identify neural representations of contextual information during recollection. Multi-voxel pattern similarity analyses revealed that CA1 represented objects that shared an episodic context as more similar than those from different episodic contexts. CA23DG showed the opposite pattern, differentiating between objects encountered in the same episodic context. The complementary characteristics of these subfields explain how we can parse our experiences into cohesive episodes while retaining the specific details that support vivid recollection.
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Recent human imaging studies show distinct but complementary characteristics of CA1 and CA3 in episodic memory.
“Recent human imaging studies shed light on the distinct but complementary characteristics of CA1 and CA3 in episodic memory (Copara et al., 2014; Dimsdale-Zucker et al., 2018).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Dimsdale-Zucker et al., 2018
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- Authors
- Dimsdale-Zucker, H. R., Ritchey, M., Ekstrom, A. D., Yonelinas, A. P., & Ranganath, C.
- Affiliations
- University of California, Davis (US)
- Boston College (US)
- Corresponding author
- Dimsdale-Zucker, Halle R.
- Venue
- Nature Communications
- Published
- 2018-01-18
- Volume
- 9
- Issue
- 1
- Pages
- 294-294
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5773497
- OpenAlex
- W2953335281
- Cited by
- 205
- References
- 70
- Citations by year
- 2026: 20 · 2025: 23 · 2024: 34 · 2023: 24 · 2022: 22 · 2021: 27 · 2020: 19 · 2019: 14 · 2018: 21 · 2017: 1
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation (1650042)
- University of California, Davis
- National Institute of Mental Health (K99MH103401, R00MH103401)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- hippocampal subfields, CA1, CA3, episodic memory, spatial memory, recollection, contextual memory, virtual reality navigation, multivariate pattern analysis, human hippocampus
- MeSH terms
- Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Mental Recall, Space Perception, Young Adult, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Memory, Episodic
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