Complementary roles of human hippocampal subregions during retrieval of spatiotemporal context
Open accessAbstract
Current evidence strongly supports the central involvement of the human medial temporal lobes (MTL) in storing and retrieving memories for recently experienced events. However, a critical remaining question regards exactly how the hippocampus and surrounding cortex represents spatiotemporal context defining an event in memory. Competing accounts suggest that this process may be accomplished by the following: (1) an overall increase in neural similarity of representations underlying spatial and temporal context, (2) a differentiation of competing spatiotemporal representations, or (3) a combination of the two processes, with different subregions performing these two functions within the MTL. To address these competing proposals, we used high-resolution functional magnetic resonance imaging targeting the MTL along with a multivariate pattern similarity approach with 19 participants. While undergoing imaging, participants performed a task in which they retrieved spatial and temporal contextual representations from a recently learned experience. Results showed that successfully retrieving spatiotemporal context defining an episode involved a decrease in pattern similarity between putative spatial and temporal contextual representations in hippocampal subfields CA2/CA3/DG, whereas the parahippocampal cortex (PHC) showed the opposite pattern. These findings could not be accounted for by differences in univariate activations for complete versus partial retrieval nor differences in correlations for correct or incorrect retrieval. Together, these data suggest that the CA2/CA3/DG serves to differentiate competing contextual representations, whereas the PHC stores a comparatively integrated trace of scene-specific context, both of which likely play important roles in successful episodic memory retrieval.
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Recent human imaging studies show distinct but complementary characteristics of CA1 and CA3 in episodic memory.
“Recent human imaging studies shed light on the distinct but complementary characteristics of CA1 and CA3 in episodic memory (Copara et al., 2014; Dimsdale-Zucker et al., 2018).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Copara et al., 2014
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- Authors
- Copara, M. S., Hassan, A. S., Kyle, C. T., Libby, L. A., Ranganath, C., & Ekstrom, A. D.
- Affiliations
- University of California, Davis (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-05-14
- Volume
- 34
- Issue
- 20
- Pages
- 6834-6842
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4019798
- OpenAlex
- W2053124204
- Cited by
- 85
- References
- 64
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 12 · 2019: 4 · 2018: 13 · 2017: 10 · 2016: 9 · 2015: 8 · 2014: 3
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-sa)
- Funders
- Alfred P. Sloan Foundation
- University of California, Davis
- National Institute of Neurological Disorders and Stroke (R01NS076856)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- hippocampal subfields, parahippocampal cortex, spatio-temporal context, episodic memory retrieval, medial temporal lobe, pattern similarity, context representation, scene memory
- MeSH terms
- Adult, Brain Mapping, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Parahippocampal Gyrus, Memory, Episodic
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