Imaging the Human Medial Temporal Lobe with High-Resolution fMRI
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High-resolution functional MRI (hr-fMRI) affords unique leverage on the functional properties of human medial temporal lobe (MTL) substructures. We review initial hr-fMRI efforts to delineate (1) encoding and retrieval processes within the hippocampal circuit, (2) hippocampal subfield contributions to pattern separation and pattern completion, and (3) the representational capabilities of distinct MTL subregions. Extant data reveal functional heterogeneity within human MTL and highlight the promise of hr-fMRI for bridging human, animal, and computational approaches to understanding MTL function.
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The hippocampus is not a unitary anatomical formation; several subfields have been identified, differentiable on histological grounds and by functional role in memory encoding and retrieval.
“The hippocampus is not, however, a unitary anatomical formation. Several subfields have been identified, which can be differentiated on both histological grounds [2], [8] and according to their functional role in memory encoding and retrieval [9], [10].”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [9]
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Amygdala lesions do not compromise the cortical network for false-belief reasoning
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- Authors
- Carr, V. A., Rissman, J., & Wagner, A. D.
- Affiliations
- Stanford University (US)
- Corresponding author
- Carr, Valerie A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 65
- Issue
- 3
- Pages
- 298-308
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2844113
- OpenAlex
- W1972569725
- Cited by
- 174
- References
- 117
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 12 · 2016: 12 · 2015: 21 · 2014: 13 · 2013: 17 · 2012: 22
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH076932)
- National Institute of Neurological Disorders and Stroke (F32NS059195)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- medial temporal lobe, high-resolution fMRI, hippocampus, hippocampal circuitry, memory encoding, memory retrieval, pattern separation, pattern completion, hippocampal subfields, human brain imaging
- MeSH terms
- Carbamide Peroxide, Animals, Brain Mapping, Drug Combinations, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Nerve Net, Neural Pathways, Peroxides, Temporal Lobe, Urea
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