Cited by 174Memory and Neural MechanismsMemory Processes and InfluencesAdvanced MRI Techniques and Applications

Imaging the Human Medial Temporal Lobe with High-Resolution fMRI

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Carr, Valerie A., Rissman, Jesse, Wagner, Anthony D.·2010·Neuron

Abstract

High-resolution functional MRI (hr-fMRI) affords unique leverage on the functional properties of human medial temporal lobe (MTL) substructures. We review initial hr-fMRI efforts to delineate (1) encoding and retrieval processes within the hippocampal circuit, (2) hippocampal subfield contributions to pattern separation and pattern completion, and (3) the representational capabilities of distinct MTL subregions. Extant data reveal functional heterogeneity within human MTL and highlight the promise of hr-fMRI for bridging human, animal, and computational approaches to understanding MTL function.

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Crossref · 10.1016/j.neuron.2009.12.022

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  • The hippocampus is not a unitary anatomical formation; several subfields have been identified, differentiable on histological grounds and by functional role in memory encoding and retrieval.

    “The hippocampus is not, however, a unitary anatomical formation. Several subfields have been identified, which can be differentiated on both histological grounds [2], [8] and according to their functional role in memory encoding and retrieval [9], [10].”

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Research works printed but not linked: 2

  1. Preston AR Bornstein AM Hutchinson JB Gaare ME Glover GH Wagner AD High-resolution fMRI of Content-sensitive Subsequent Memory Responses in Human Medial Temporal Lobe J Cogn Neurosci 2010 22 156 173 PMC2854293 19199423
  2. Rolls ET A theory of hippocampal function in memory Hippocampus 1996 6 601 620 9034849

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Authors
Carr, V. A., Rissman, J., & Wagner, A. D.
Affiliations
Stanford University (US)
Corresponding author
Carr, Valerie A.
Venue
Neuron
Publisher
Elsevier BV
Published
2010-02
Volume
65
Issue
3
Pages
298-308
ISSN
0896-6273 (ISSN-L)
OpenAlex
W1972569725
Cited by
174
References
117
Citations by year
2026: 5 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 12 · 2016: 12 · 2015: 21 · 2014: 13 · 2013: 17 · 2012: 22
FWCI
1.35
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH076932)
  • National Institute of Neurological Disorders and Stroke (F32NS059195)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
medial temporal lobe, high-resolution fMRI, hippocampus, hippocampal circuitry, memory encoding, memory retrieval, pattern separation, pattern completion, hippocampal subfields, human brain imaging
MeSH terms
Carbamide Peroxide, Animals, Brain Mapping, Drug Combinations, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Nerve Net, Neural Pathways, Peroxides, Temporal Lobe, Urea

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