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Cited by 437Pain Management and Placebo EffectNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

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Placebo in emotional processing—induced expectations of anxiety relief activate a generalized modulatory network

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Petrovic, Predrag, Dietrich, Thomas, Fransson, Peter, Andersson, Jesper, Carlsson, Katrina, Ingvar, Martin·2005·Neuron
DOI 10.1016/j.neuron.2005.05.023
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Abstract

Placebo analgesia and reward processing share several features. For instance, expectations have a strong influence on the subsequent emotional experience of both. Recent imaging data indicate similarities in the underlying neuronal network. We hypothesized that placebo analgesia is a special case of reward processing and that placebo treatment could modulate emotional perception in the same way as does pain perception. The behavioral part of this study indicates that placebo treatment has an effect on how subjects perceive unpleasant pictures. Furthermore, event-related fMRI demonstrated that the same modulatory network, including the rostral anterior cingulate cortex and the lateral orbitofrontal cortex, is involved in both emotional placebo and placebo analgesia. These effects were correlated with the reported placebo effect and were predicted by the amount of treatment expectation induced on a previous day. Thus, the placebo effect may be considered to be a general process of modulation induced by the subjects' expectations.

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  1. Amanzio, 1999, Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems, J. Neurosci., 19, 484, 10.1523/JNEUROSCI.19-01-00484.1999 · DOI · Paper page
  2. Becerra, 2001, Reward circuitry activation by noxious thermal stimuli, Neuron, 32, 927, 10.1016/S0896-6273(01)00533-5 · DOI
  3. Bechara, 1997, Deciding advantageously before knowing the advantageous strategy, Science, 275, 1293, 10.1126/science.275.5304.1293 · DOI · Paper page
  4. Berridge, 2003, Parsing reward, Trends Neurosci., 26, 507, 10.1016/S0166-2236(03)00233-9 · DOI · Paper page
  5. Blakemore, 1998, Central cancellation of self-produced tickle sensation, Nat. Neurosci., 1, 635, 10.1038/2870 · DOI · Paper page
  6. Breiter, 2001, Functional imaging of neural responses to expectancy and experience of monetary gains and losses, Neuron, 30, 619, 10.1016/S0896-6273(01)00303-8 · DOI · Paper page
  7. Bush, 2000, Cognitive and emotional influences in anterior cingulate cortex, Trends Cogn. Sci., 4, 215, 10.1016/S1364-6613(00)01483-2 · DOI · Paper page
  8. Davidson, 2000, Dysfunction in the neural circuitry of emotion regulation—a possible prelude to violence, Science, 289, 591, 10.1126/science.289.5479.591 · DOI · Paper page
  9. de la Fuente-Fernandez, 2001, Expectation and dopamine release: mechanism of the placebo effect in Parkinson’s disease, Science, 293, 1164, 10.1126/science.1060937 · DOI
  10. Ernst, 2004, Choice selection and reward anticipation: an fMRI study, Neuropsychologia, 42, 1585, 10.1016/j.neuropsychologia.2004.05.011 · DOI · Paper page
  11. Friston, 1995, Statistical parametric maps in functional imaging: A general linear approach, Hum. Brain Mapp., 2, 189, 10.1002/hbm.460020402 · DOI · Paper page
  12. Geday, 2003, Emotional valence modulates activity in the posterior fusiform gyrus and inferior medial prefrontal cortex in social perception, Neuroimage, 18, 675, 10.1016/S1053-8119(02)00038-1 · DOI
  13. Hsieh, 1999, Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study, Neurosci. Lett., 262, 61, 10.1016/S0304-3940(99)00060-9 · DOI · Paper page
  14. Ingvar, 1985, “Memory of the future”: an essay on the temporal organization of conscious awareness, Hum. Neurobiol., 4, 127
  15. Kaasinen, 2004, Expectation of caffeine induces dopaminergic responses in humans, Eur. J. Neurosci., 19, 2352, 10.1111/j.1460-9568.2004.03310.x · DOI · Paper page
  16. Kirsch, 2003, Anticipation of reward in a nonaversive differential conditioning paradigm and the brain reward system: an event-related fMRI study, Neuroimage, 20, 1086, 10.1016/S1053-8119(03)00381-1 · DOI
  17. Knutson, 2001, Dissociation of reward anticipation and outcome with event-related fMRI, Neuroreport, 12, 3683, 10.1097/00001756-200112040-00016 · DOI · Paper page
  18. Koyama, 1998, Nociceptive neurons in the macaque anterior cingulate activate during anticipation of pain, Neuroreport, 9, 2663, 10.1097/00001756-199808030-00044 · DOI
  19. Kringelbach, 2003, Neural correlates of rapid reversal learning in a simple model of human social interaction, Neuroimage, 20, 1371, 10.1016/S1053-8119(03)00393-8 · DOI
  20. Liberzon, 2002, mu-Opioid receptors and limbic responses to aversive emotional stimuli, Proc. Natl. Acad. Sci. USA, 99, 7084, 10.1073/pnas.102174799 · DOI
  21. Lieberman, 2004, The neural correlates of placebo effects: a disruption account, Neuroimage, 22, 447, 10.1016/j.neuroimage.2004.01.037 · DOI
  22. Mellers, 2000, Choice and the relative pleasure of consequences, Psychol. Bull., 126, 910, 10.1037/0033-2909.126.6.910 · DOI
  23. Mesulam, 1998, From sensation to cognition, Brain, 121, 1013, 10.1093/brain/121.6.1013 · DOI · Paper page
  24. Montgomery, 1997, Classical conditioning and the placebo effect, Pain, 72, 107, 10.1016/S0304-3959(97)00016-X · DOI · Paper page
  25. Ochsner, 2002, Rethinking feelings: an FMRI study of the cognitive regulation of emotion, J. Cogn. Neurosci., 14, 1215, 10.1162/089892902760807212 · DOI · Paper page
  26. O’Doherty, 2001, Abstract reward and punishment representations in the human orbitofrontal cortex, Nat. Neurosci., 4, 95, 10.1038/82959 · DOI · Paper page
  27. O’Doherty, 2002, Neural responses during anticipation of a primary taste reward., Neuron, 33, 815, 10.1016/S0896-6273(02)00603-7 · DOI · Paper page
  28. Pelchat, 2002, Of human bondage: food craving, obsession, compulsion, and addiction, Physiol. Behav., 76, 347, 10.1016/S0031-9384(02)00757-6 · DOI
  29. Petrovic, 2002, Topical review: Imaging cognitive modulation of pain processing, Pain, 95, 1, 10.1016/S0304-3959(01)00467-5 · DOI · Paper page
  30. Petrovic, 2002, Placebo and opioid analgesia—Imagine a shared neuronal network, Science, 295, 1737, 10.1126/science.1067176 · DOI · Paper page
  31. Peyron, 2000, Functional imaging of brain responses to pain. A review and meta-analysis (2000), Neurophysiol. Clin., 30, 263, 10.1016/S0987-7053(00)00227-6 · DOI · Paper page
  32. Ploghaus, 1999, Dissociating pain from its anticipation in the human brain, Science, 284, 1979, 10.1126/science.284.5422.1979 · DOI · Paper page
  33. Price, 1999, An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm, Pain, 83, 147, 10.1016/S0304-3959(99)00081-0 · DOI
  34. Ramnani, 2003, Instructed delay activity in the human prefrontal cortex is modulated by monetary reward expectation, Cereb. Cortex, 13, 318, 10.1093/cercor/13.3.318 · DOI
  35. Schoenbaum, 2001, Integrating orbitofrontal cortex into prefrontal theory: common processing themes across species and subdivisions, Learn. Mem., 8, 134, 10.1101/lm.39901 · DOI
  36. Schultz, 2002, Getting formal with dopamine and reward, Neuron, 36, 241, 10.1016/S0896-6273(02)00967-4 · DOI · Paper page
  37. Surguladze, 2003, A preferential increase in the extrastriate response to signals of danger, Neuroimage, 19, 1317, 10.1016/S1053-8119(03)00085-5 · DOI
  38. Tremblay, 1999, Relative reward preference in primate orbitofrontal cortex, Nature, 398, 704, 10.1038/19525 · DOI · Paper page
  39. Ueda, 2003, Brain activity during expectancy of emotional stimuli: an fMRI study, Neuroreport, 14, 51, 10.1097/00001756-200301200-00010 · DOI
  40. Wager, 2004, Placebo-induced changes in FMRI in the anticipation and experience of pain, Science, 303, 1162, 10.1126/science.1093065 · DOI · Paper page
  41. Voudouris, 1989, Conditioned response models of placebo phenomena: further support, Pain, 38, 109, 10.1016/0304-3959(89)90080-8 · DOI
  42. Vuilleumier, 2001, Effects of attention and emotion on face processing in the human brain: an event-related fMRI study, Neuron, 30, 829, 10.1016/S0896-6273(01)00328-2 · DOI · Paper page
  43. Zubieta, 2003, Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission, Arch. Gen. Psychiatry, 60, 1145, 10.1001/archpsyc.60.11.1145 · DOI

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Metadata

Authors
Petrovic, P., Dietrich, T., Fransson, P., Andersson, J., Carlsson, K., & Ingvar, M.
Affiliations
Karolinska University Hospital (SE)
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2005-06
Volume
46
Issue
6
Pages
957-969
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2005.05.023
OpenAlex
W1979589689
Cited by
437
References
0
Citations by year
2026: 6 · 2025: 15 · 2024: 8 · 2023: 9 · 2022: 19 · 2021: 19 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 16 · 2016: 24 · 2015: 25 · 2014: 28 · 2013: 34 · 2012: 25
FWCI
12.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Petrus och Augusta Hedlunds Stiftelse
  • Sveriges Läkarförbund
  • Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
placebo effect, emotional processing, anxiety reduction, reward processing, placebo analgesia, treatment expectations, unpleasant pictures, rostral anterior cingulate cortex, lateral orbitofrontal cortex, pain perception
MeSH terms
Adult, Anxiety, Benzodiazepines, Brain Mapping, Emotions, Female, Flumazenil, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Nerve Net, Oxygen, Photic Stimulation, Placebos, Time Factors, Anti-Anxiety Agents, Placebo Effect

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