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Cited by 437Pain Management and Placebo EffectNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

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Placebo in emotional processing—induced expectations of anxiety relief activate a generalized modulatory network

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Petrovic, Predrag, Dietrich, Thomas, Fransson, Peter, Andersson, Jesper, Carlsson, Katrina, Ingvar, Martin·2005·Neuron
DOI 10.1016/j.neuron.2005.05.023
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Abstract

Placebo analgesia and reward processing share several features. For instance, expectations have a strong influence on the subsequent emotional experience of both. Recent imaging data indicate similarities in the underlying neuronal network. We hypothesized that placebo analgesia is a special case of reward processing and that placebo treatment could modulate emotional perception in the same way as does pain perception. The behavioral part of this study indicates that placebo treatment has an effect on how subjects perceive unpleasant pictures. Furthermore, event-related fMRI demonstrated that the same modulatory network, including the rostral anterior cingulate cortex and the lateral orbitofrontal cortex, is involved in both emotional placebo and placebo analgesia. These effects were correlated with the reported placebo effect and were predicted by the amount of treatment expectation induced on a previous day. Thus, the placebo effect may be considered to be a general process of modulation induced by the subjects' expectations.

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Metadata

Authors
Petrovic, P., Dietrich, T., Fransson, P., Andersson, J., Carlsson, K., & Ingvar, M.
Affiliations
Karolinska University Hospital (SE)
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2005-06
Volume
46
Issue
6
Pages
957-969
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2005.05.023
OpenAlex
W1979589689
Cited by
437
References
0
Citations by year
2026: 6 · 2025: 15 · 2024: 8 · 2023: 9 · 2022: 19 · 2021: 19 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 16 · 2016: 24 · 2015: 25 · 2014: 28 · 2013: 34 · 2012: 25
FWCI
12.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Petrus och Augusta Hedlunds Stiftelse
  • Sveriges Läkarförbund
  • Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
placebo effect, emotional processing, anxiety reduction, reward processing, placebo analgesia, treatment expectations, unpleasant pictures, rostral anterior cingulate cortex, lateral orbitofrontal cortex, pain perception
MeSH terms
Adult, Anxiety, Benzodiazepines, Brain Mapping, Emotions, Female, Flumazenil, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Nerve Net, Oxygen, Photic Stimulation, Placebos, Time Factors, Anti-Anxiety Agents, Placebo Effect

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