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Differential Attention-Dependent Response Modulation across Cell Classes in Macaque Visual Area V4
Open accessAbstract
The cortex contains multiple cell types, but studies of attention have not distinguished between them, limiting understanding of the local circuits that transform attentional feedback into improved visual processing. Parvalbumin-expressing inhibitory interneurons can be distinguished from pyramidal neurons based on their briefer action potential durations. We recorded neurons in area V4 as monkeys performed an attention-demanding task. We find that the distribution of action potential durations is strongly bimodal. Neurons with narrow action potentials have higher firing rates and larger attention-dependent increases in absolute firing rate than neurons with broad action potentials. The percentage increase in response is similar across the two classes. We also find evidence that attention increases the reliability of the neuronal response. This modulation is more than two-fold stronger among putative interneurons. These findings lead to the surprising conclusion that the strongest attentional modulation occurs among local interneurons that do not transmit signals between areas.
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“Selective attention reduces neuronal variability (Mitchell et al., 2007)”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Mitchell et al., 2007
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Metadata
- Authors
- Mitchell, J. F., Sundberg, K. A., & Reynolds, J. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Mitchell, Jude F.
- Reynolds, John H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 55
- Issue
- 1
- Pages
- 131-141
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2115569429
- Cited by
- 665
- References
- 66
- Citations by year
- 2026: 18 · 2025: 33 · 2024: 34 · 2023: 32 · 2022: 28 · 2021: 40 · 2020: 27 · 2019: 45 · 2018: 30 · 2017: 26 · 2016: 26 · 2015: 45 · 2014: 49 · 2013: 40 · 2012: 49
- FWCI
- 18.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2244 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (EY016161)
- National Science Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- visual attention, area V4, parvalbumin interneurons, action potential duration, neuronal cell types, attentional modulation, firing rate, response reliability, pyramidal neurons, macaque cortex, local circuits
- MeSH terms
- Action Potentials, Animals, Attention, Brain Mapping, Cues, Data Interpretation, Statistical, Eye Movements, Interneurons, Macaca mulatta, Magnetic Resonance Imaging, Neurons, Psychomotor Performance, Visual Cortex, Pyramidal Cells
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