Cited by 111Neuroscience and Neuropharmacology ResearchEpigenetics and DNA MethylationMemory and Neural Mechanisms

DNA methylation regulates neuronal glutamatergic synaptic scaling

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Meadows, Jarrod P., Guzman-Karlsson, Mikael C., Phillips, Scott, Holleman, Cassie, Posey, Jessica L., Day, Jeremy J., Hablitz, John J., Sweatt, J. David·2015·Science Signaling

Abstract

Epigenetically mediated changes in postsynaptic glutamate receptor expression enable neurons to adjust responsiveness to their environment.

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Crossref · 10.1126/scisignal.aab0715

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  • Inhibiting DNMT activity increases miniature excitatory postsynaptic currents in cultured cortical neurons, suggesting that DNA methylation regulates glutamatergic synaptic strength.

    “Additionally, inhibiting DNMT activity increases miniature excitatory postsynaptic currents in cultured cortical neurons, suggesting that DNA methylation regulates glutamatergic synaptic strength [ 76 ].”

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Authors
Meadows, J. P., Guzman-Karlsson, M. C., Phillips, S., Holleman, C., Posey, J. L., Day, J. J., Hablitz, J. J., & Sweatt, J. D.
Affiliations
  • University of Alabama at Birmingham (US)
  • Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Corresponding author
  • Hablitz, John J.
  • Sweatt, J. David
Venue
Science Signaling
Published
2015-06-23
Volume
8
Issue
382
Pages
ra61-ra61
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2104846922
Cited by
111
References
76
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 17 · 2016: 17 · 2015: 4 · 2014: 1
FWCI
7.78
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Defense Advanced Research Projects Agency (HR0011-12-1-0015)
  • NIH (P30-NS047466, MH091122, MH57014, DA034681, T32GM008361, T32NS061788)
  • Evelyn F. McKnight Brain Research Foundation
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
DNA methylation, glutamatergic synapses, synaptic homeostasis, synaptic plasticity, long-term memory, DNA methyltransferase inhibition, RG108, DNMT1, DNMT3A, TET1, glutamate receptors, miniature excitatory postsynaptic currents, transcription, cortical neurons, tetrodotoxin
MeSH terms
DNA (Cytosine-5-)-Methyltransferase 1, DNA Methyltransferase 3A, Animals, DNA (Cytosine-5-)-Methyltransferases, Neurons, Phthalimides, Synapses, Tetrodotoxin, Transcription, Genetic, Tryptophan, DNA Methylation, Rats, Synaptic Potentials, Gene Knockdown Techniques

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