DNA methylation regulates neuronal glutamatergic synaptic scaling
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Epigenetically mediated changes in postsynaptic glutamate receptor expression enable neurons to adjust responsiveness to their environment.
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Inhibiting DNMT activity increases miniature excitatory postsynaptic currents in cultured cortical neurons, suggesting that DNA methylation regulates glutamatergic synaptic strength.
“Additionally, inhibiting DNMT activity increases miniature excitatory postsynaptic currents in cultured cortical neurons, suggesting that DNA methylation regulates glutamatergic synaptic strength [ 76 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [76]
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Self-citation
- Authors
- Meadows, J. P., Guzman-Karlsson, M. C., Phillips, S., Holleman, C., Posey, J. L., Day, J. J., Hablitz, J. J., & Sweatt, J. D.
- Affiliations
- University of Alabama at Birmingham (US)
- Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Corresponding author
- Hablitz, John J.
- Sweatt, J. David
- Venue
- Science Signaling
- Published
- 2015-06-23
- Volume
- 8
- Issue
- 382
- Pages
- ra61-ra61
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC4764068
- OpenAlex
- W2104846922
- Cited by
- 111
- References
- 76
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 17 · 2016: 17 · 2015: 4 · 2014: 1
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Defense Advanced Research Projects Agency (HR0011-12-1-0015)
- NIH (P30-NS047466, MH091122, MH57014, DA034681, T32GM008361, T32NS061788)
- Evelyn F. McKnight Brain Research Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- DNA methylation, glutamatergic synapses, synaptic homeostasis, synaptic plasticity, long-term memory, DNA methyltransferase inhibition, RG108, DNMT1, DNMT3A, TET1, glutamate receptors, miniature excitatory postsynaptic currents, transcription, cortical neurons, tetrodotoxin
- MeSH terms
- DNA (Cytosine-5-)-Methyltransferase 1, DNA Methyltransferase 3A, Animals, DNA (Cytosine-5-)-Methyltransferases, Neurons, Phthalimides, Synapses, Tetrodotoxin, Transcription, Genetic, Tryptophan, DNA Methylation, Rats, Synaptic Potentials, Gene Knockdown Techniques
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