Inhibitory engrams in perception and memory

Barron, Helen C.; Vogels, Tim P.; Behrens, Timothy E.; Ramaswami, Mani

doi:10.1073/pnas.1701812114

Cited by 147Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Inhibitory engrams in perception and memory

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Barron, Helen C., Vogels, Tim P., Behrens, Timothy E., Ramaswami, Mani·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1701812114PMC PMC5495250

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Abstract

Nervous systems use excitatory cell assemblies to encode and represent sensory percepts. Similarly, synaptically connected cell assemblies or “engrams” are thought to represent memories of past experience. Multiple lines of recent evidence indicate that brain systems create and use inhibitory replicas of excitatory representations for important cognitive functions. Such matched “inhibitory engrams” can form through homeostatic potentiation of inhibition onto postsynaptic cells that show increased levels of excitation. Inhibitory engrams can reduce behavioral responses to familiar stimuli, thereby resulting in behavioral habituation. In addition, by preventing inappropriate activation of excitatory memory engrams, inhibitory engrams can make memories quiescent, stored in a latent form that is available for context-relevant activation. In neural networks with balanced excitatory and inhibitory engrams, the release of innate responses and recall of associative memories can occur through focused disinhibition. Understanding mechanisms that regulate the formation and expression of inhibitory engrams in vivo may help not only to explain key features of cognition but also to provide insight into transdiagnostic traits associated with psychiatric conditions such as autism, schizophrenia, and posttraumatic stress disorder.

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Early Memories of Individuals on the Autism Spectrum Assessed Using Online Self-Reports
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Olfactory habituation: Fresh insights from flies
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Memory engrams: Recalling the past and imagining the future
Josselyn, S. A., & Tonegawa, S. (2020) · Science · doi:10.1126/science.aaw4325 · Cited by 1,087 · see citing works
Beyond the Status Quo: A Role for Beta Oscillations in Endogenous Content (Re)Activation
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Memory Allocation: Mechanisms and Function
Josselyn, S. A., & Frankland, P. W. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061956 · Cited by 221 · see citing works
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Forgetting as a form of adaptive engram cell plasticity
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The role of inhibitory circuits in hippocampal memory processing
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Precise excitation-inhibition balance controls gain and timing in the hippocampus
Bhatia, A., Moza, S., & Bhalla, U. S. (2019) · eLife · doi:10.7554/elife.43415 · Cited by 136 · see citing works
Different states of priority recruit different neural representations in visual working memory
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Economic Choice as an Untangling of Options into Actions
Yoo, S. B. M., & Hayden, B. Y. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.038 · Cited by 104 · see citing works
The Synaptic Theory of Memory: A Historical Survey and Reconciliation of Recent Opposition
Langille, J. J., & Brown, R. E. (2018) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00052 · Cited by 109 · see citing works
The Hippocampus and Neocortical Inhibitory Engrams Protect against Memory Interference
Koolschijn, R. S., Emir, U. E., Pantelides, A. C., Nili, H., Behrens, T. E. J., & Barron, H. C. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.042 · Cited by 103 · see citing works
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Regulation of circuit organization and function through inhibitory synaptic plasticity
Wu, Y. K., Miehl, C., & Gjorgjieva, J. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.10.006 · Cited by 102 · see citing works
Regional balance between glutamate+glutamine and GABA+ in the resting human brain
Steel, A., Mikkelsen, M. E., Edden, R. A. E., & Robertson, C. E. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117112 · Cited by 70 · see citing works
Memory and Forgetting
Brewin, C. R. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0950-7 · Cited by 70 · see citing works
Inhibitory microcircuits for top-down plasticity of sensory representations
Wilmes, K. A., & Claudia Clopath, A. (2019) · Nature Communications · doi:10.1038/s41467-019-12972-2 · Cited by 69 · see citing works
The times they are a-changin’: a proposal on how brain flexibility goes beyond the obvious to include the concepts of “upward” and “downward” to neuroplasticity
Diniz, C. R. A. F., & Crestani, A. P. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01931-x · Cited by 67 · see citing works
Metastable dynamics of neural circuits and networks
Brinkman, B. A. W., Yan, H., Maffei, A., Park, I. M., Fontanini, A., Wang, J., & La Camera, G. (2022) · Applied Physics Reviews · doi:10.1063/5.0062603 · Cited by 64 · see citing works
The generation of cortical novelty responses through inhibitory plasticity
Schulz, A., Miehl, C., Berry, M. J., & Gjorgjieva, J. (2021) · eLife · doi:10.7554/elife.65309 · Cited by 64 · see citing works
Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer’s disease neuropathologic change
Scaduto, P., Lauterborn, J. C., Cox, C. D., Fracassi, A., Zeppillo, T., Gutierrez, B. A., Keene, C. D., Crane, P. K., Mukherjee, S., Russell, W. K., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02526-0 · Cited by 68 · see citing works
Habituation Learning Is a Widely Affected Mechanism in Drosophila Models of Intellectual Disability and Autism Spectrum Disorders
Fencková, M., Blok, L. E. R., Asztalos, L., Goodman, D. P., Čížek, P., Singgih, E. L., Glennon, J. C., IntHout, J., Zweier, C., Eichler, E. E., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.029 · Cited by 66 · see citing works
Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics
Valero, M., Zutshi, I., Yoon, E., & Buzsáki, G. (2022) · Science · doi:10.1126/science.abm1891 · Cited by 60 · see citing works
Learning excitatory-inhibitory neuronal assemblies in recurrent networks
Mackwood, O., Naumann, L., & Sprekeler, H. (2021) · eLife · doi:10.7554/elife.59715 · Cited by 64 · see citing works
Intellectual disability and autism spectrum disorders ‘on the fly’: insights from Drosophila
Coll-Tané, M., Krebbers, A., Castells‐Nobau, A., Zweier, C., & Schenck, A. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.039180 · Cited by 55 · see citing works
TMS-induced neuronal plasticity enables targeted remodeling of visual cortical maps
Kozyrev, V., Staadt, R., Eysel, U. T., & Jancke, D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802798115 · Cited by 49 · see citing works
Dynamic and heterogeneous neural ensembles contribute to a memory engram
Sweis, B. M., Mau, W., Rabinowitz, S., & Cai, D. J. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.11.017 · Cited by 50 · see citing works
Learning to live with Dale’s principle: ANNs with separate excitatory and inhibitory unitsPreprint
Cornford, J. H., Kalajdzievski, D., Leite, M., Lamarquette, A., Kullmann, D. M., & Richards, B. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.02.364968 · Cited by 43 · see citing works
The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles
Capogna, M., Castillo, P. E., & Maffei, A. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14907 · Cited by 41 · see citing works
Neural inhibition for continual learning and memory
Barron, H. C. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.09.007 · Cited by 38 · see citing works
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Formation and computational implications of assemblies in neural circuits
Miehl, C., Onasch, S., Festa, D., & Gjorgjieva, J. (2022) · The Journal of Physiology · doi:10.1113/jp282750 · Cited by 38 · see citing works
A neural code for egocentric spatial maps in the human medial temporal lobePreprint
Kunz, L., Brandt, A., Reinacher, P. C., Staresina, B. P., Reifenstein, E. T., Weidemann, C. T., Herweg, N. A., Tsitsiklis, M., Kempter, R., Kahana, M. J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.03.973131 · Cited by 38 · see citing works
Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses
Wiera, G., & Mozrzymas, J. W. (2021) · Cells · doi:10.3390/cells10082055 · Cited by 36 · see citing works
Long-term plasticity of hippocampal interneurons during in vivo memory processes
Lamsa, K. P., & Lau, P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.08.006 · Cited by 37 · see citing works
Functionally distinct NPAS4-expressing somatostatin interneuron ensembles critical for motor skill learning
Yang, J., Serrano, P., Yin, X., Sun, X., Lin, Y., & Chen, S. X. (2022) · Neuron · doi:10.1016/j.neuron.2022.08.018 · Cited by 36 · see citing works
Engram cell connectivity as a mechanism for information encoding and memory function
Luis, C. O. S., Pezzoli, M., Urrieta, E., & Ryan, T. J. (2023) · Current Biology · doi:10.1016/j.cub.2023.10.074 · Cited by 33 · see citing works
Somatostatin and the pathophysiology of Alzheimer’s disease
Almeida, V. N. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102270 · Cited by 30 · see citing works
The dendritic engram
Kastellakis, G., Tasciotti, S., Pandi, I., & Poirazi, P. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1212139 · Cited by 34 · see citing works
Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer’s disease
Lazarov, O., Gupta, M., Kumar, P., Morrissey, Z. D., & Phan, T. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102601 · Cited by 29 · see citing works
An engram of intentionally forgotten information
ten Oever, S., Sack, A. T., Oehrn, C. R., & Axmacher, N. (2021) · Nature Communications · doi:10.1038/s41467-021-26713-x · Cited by 27 · see citing works
The thalamic reticular nucleus orchestrates social memory
Wang, F., Sun, H., Chen, M., Feng, B., Lu, Y., Lyu, M., Cui, D., Zhai, Y., Zhang, Y., Zhu, Y., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.04.013 · Cited by 28 · see citing works
Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation
Tomé, D. F., Sadeh, S., & Clopath, C. (2022) · Nature Communications · doi:10.1038/s41467-022-28339-z · Cited by 27 · see citing works
Altered predictive control during memory suppression in PTSD
Leone, G., Postel, C., Mary, A., Fraisse, F., Vallée, T., Viader, F., Sayette, V. D. L., Peschanski, D., Dayan, J., Eustache, F., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30855-x · Cited by 27 · see citing works
State-Dependent Memory: Neurobiological Advances and Prospects for Translation to Dissociative Amnesia
Radulovic, J., Lee, R., & Ortony, A. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00259 · Cited by 26 · see citing works
Perineuronal Nets in the CNS: Architects of Memory and Potential Therapeutic Target in Neuropsychiatric Disorders
Li, X., Wu, X., Lu, T., Kuang, C., Si, Y., Zheng, W., Li, Z., & Xue, Y.-X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063412 · Cited by 25 · see citing works
Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice
Fujikawa, R., Ramsaran, A. I., Guskjolen, A. J., de la Parra, J., Zou, Y., Mocle, A. J., Josselyn, S. A., & Frankland, P. W. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02585-7 · Cited by 28 · see citing works
Neuromorphic Optical Data Storage Enabled by Nanophotonics: A Perspective
Lamon, S., Zhang, Q., Yu, H., & Gu, M. (2024) · ACS Photonics · doi:10.1021/acsphotonics.3c01253 · Cited by 24 · see citing works
Multiple network properties overcome random connectivity to enable stereotypic sensory responses
Mittal, A. M., Gupta, D., Singh, A., Lin, A. C., & Gupta, N. (2020) · Nature Communications · doi:10.1038/s41467-020-14836-6 · Cited by 22 · see citing works
Roles and Transcriptional Responses of Inhibitory Neurons in Learning and Memory
Giorgi, C., & Marinelli, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.689952 · Cited by 24 · see citing works
The Engram’s Dark Horse: How Interneurons Regulate State-Dependent Memory Processing and Plasticity
Raven, F., & Aton, S. J. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.750541 · Cited by 27 · see citing works
GABAergic Interneurons with Nonlinear Dendrites: From Neuronal Computations to Memory Engrams
Tzilivaki, A., Kastellakis, G., Schmitz, D., & Poirazi, P. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.11.033 · Cited by 22 · see citing works
Long-term plasticity of inhibitory synapses in the hippocampus and spatial learning depends on matrix metalloproteinase 3
Wiera, G., Lebida, K., Lech, A. M., Brzdąk, P., Hove, I. V., Groef, L. D., Moons, L., Petrini, E. M., Barberis, A., & Mozrzymas, J. W. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03640-6 · Cited by 22 · see citing works
Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila
Fencková, M., Muha, V., Mariappa, D., Catinozzi, M., Czajewski, I., Blok, L. E. R., Ferenbach, A. T., Storkebaum, E., Schenck, A., & van Aalten, D. M. F. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010159 · Cited by 23 · see citing works
Genetics, molecular control and clinical relevance of habituation learning
Blok, L. E. R., Boon, M., van Reijmersdal, B., Höffler, K. D., Fencková, M., & Schenck, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104883 · Cited by 21 · see citing works
Parvalbumin interneuron cell-to-network plasticity: mechanisms and therapeutic avenues
Hadler, M. D., Alle, H., & Geiger, J. R. P. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.04.003 · Cited by 20 · see citing works
Stable habituation deficits in the early stage of psychosis: a 2-year follow-up study
Avery, S. N., McHugo, M., Armstrong, K., Blackford, J. U., Woodward, N. D., & Heckers, S. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01167-9 · Cited by 18 · see citing works
An adaptive behavioral control motif mediated by cortical axo-axonic inhibition
Jung, K., Chang, M., Steinecke, A., Burke, B., Choi, Y., Oisi, Y., Fitzpatrick, D., Taniguchi, H., & Kwon, H. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01380-x · Cited by 18 · see citing works
Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction
Bayer, H., Hassell, J. E., Oleksiak, C. R., Garcia, G. M., Vaughan, H. L., Juliano, V. A. L., & Maren, S. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01961-9 · Cited by 19 · see citing works
Extended Temporal Association Memory by Modulations of Inhibitory Circuits
Haga, T., & Fukai, T. (2019) · Physical Review Letters · doi:10.1103/physrevlett.123.078101 · Cited by 19 · see citing works
Habituation as a neural algorithm for online odor discrimination
Shen, Y., Dasgupta, S., & Navlakha, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1915252117 · Cited by 19 · see citing works
TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis
Jiang, Z., Li, W., Yao, L., Saed, B., Rao, Y., Grewe, B. S., McGinley, A., Varga, K. T., Alford, S. T., Hu, Y., et al. (2021) · eLife · doi:10.7554/elife.66709 · Cited by 18 · see citing works
A Drosophila Circuit for Habituation Override
Trisal, S., Aranha, M. M., Chodankar, A., VijayRaghavan, K., & Ramaswami, M. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1842-21.2022 · Cited by 17 · see citing works
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Memory encoding and retrieval by retrosplenial parvalbumin interneurons are impaired in Alzheimer’s disease model mice
Park, K., Kohl, M. M., & Kwag, J. (2023) · Current Biology · doi:10.1016/j.cub.2023.12.014 · Cited by 18 · see citing works
On the origin of memory neurons in the human hippocampus
Kolibius, L. D., Josselyn, S. A., & Hanslmayr, S. (2025) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2025.01.013 · Cited by 17 · see citing works
Circuit dynamics of superficial and deep CA1 pyramidal cells and inhibitory cells in freely moving macaques
Abbaspoor, S., & Hoffman, K. L. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114519 · Cited by 15 · see citing works
Probing neuronal functions with precise and targeted laser ablation in the living cortex
Cheng, Z., Han, Y., Wei, B., Lai, B., Li, B., Cui, M., & Gan, W. (2021) · Optica · doi:10.1364/optica.433562 · Cited by 15 · see citing works
CA1 Engram Cell Dynamics Before and After LearningPreprint
Monasterio, A. H., Lienkaemper, C., Coello, S., Senne, R. A., Ocker, G. K., Scott, B. B., & Ramirez, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.16.589790 · Cited by 15 · see citing works
Neuronal Activity at Synapse Resolution: Reporters and Effectors for Synaptic Neuroscience
Gobbo, F., & Cattaneo, A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.572312 · Cited by 13 · see citing works
Plasticity of human resilience mechanisms
Leone, G., Casanave, H., Postel, C., Fraisse, F., Vallée, T., Sayette, V. D. L., Dayan, J., Peschanski, D., Eustache, F., & Gagnepain, P. (2025) · Science Advances · doi:10.1126/sciadv.adq8336 · Cited by 16 · see citing works
Learning better with Dale’s Law: A Spectral Perspective
Li, P., Cornford, J. H., Ghosh, A., & Richards, B. (2023) · neural information processing systems · doi:10.52202/075280-0045 · Cited by 14 · see citing works
Awake replay: off the clock but on the job
van der Meer, M. A. A., & Bendor, D. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.02.006 · Cited by 15 · see citing works
Cortical control of chandelier cells in neural codes
Jung, K., Choi, Y., & Kwon, H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.992409 · Cited by 11 · see citing works
Fast Regulation of GABAAR Diffusion Dynamics by Nogo-A Signaling
Fricke, S., Metzdorf, K., Ohm, M., Haak, S., Heine, M., Körte, M., & Zagrebelsky, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.015 · Cited by 13 · see citing works
Extracellular matrix integrity regulates GABAergic plasticity in the hippocampus
Jabłońska, J., Wiera, G., & Mozrzymas, J. W. (2024) · Matrix Biology · doi:10.1016/j.matbio.2024.11.001 · Cited by 12 · see citing works
Network-Centered Homeostasis Through Inhibition Maintains Hippocampal Spatial Map and Cortical Circuit Function
Kaleb, K., Pedrosa, V., & Clopath, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.109577 · Cited by 12 · see citing works
Sparse Associative Memory
Hoffmann, H. (2019) · Neural Computation · doi:10.1162/neco_a_01181 · Cited by 12 · see citing works
A model of amygdala function following plastic changes at specific synapses during extinction
Bennett, M. R., Farnell, L., Gibson, W. G., & Lagopoulos, J. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100159 · Cited by 12 · see citing works
Input specificity of NMDA-dependent GABAergic plasticity in the hippocampus
Wiera, G., Jabłońska, J., Lech, A. M., & Mozrzymas, J. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-70278-w · Cited by 11 · see citing works
Attentional capture mediates the emergence and suppression of intrusive memories
Legrand, N., Etard, O., Viader, F., Clochon, P., Doidy, F., Eustache, F., & Gagnepain, P. (2022) · iScience · doi:10.1016/j.isci.2022.105516 · Cited by 11 · see citing works
Registered Report: Transcriptional Analysis of Savings Memory Suggests Forgetting is Due to Retrieval Failure
Rosiles, T., Nguyen, M. L., Duron, M., Garcia, A., Garcia, G., Gordon, H., Juarez, L., Calin‐Jageman, I. E., & Calin-Jageman, R. J. (2020) · eNeuro · doi:10.1523/eneuro.0313-19.2020 · Cited by 11 · see citing works
The glucocorticoid footprint on the memory engram
Jeanneteau, F. D., & Coutellier, L. D. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100378 · Cited by 10 · see citing works
Exploring the memory: existing activity-dependent tools to tag and manipulate engram cells
Pang, B., Wu, X., Chen, H., Yan, Y., Du, Z., Yu, Z., Yang, X., Wang, W., & Lu, K. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1279032 · Cited by 9 · see citing works
If Engrams Are the Answer, What Is the Question?
O'Sullivan, F., & Ryan, T. J. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-62983-9_15 · Cited by 9 · see citing works
High Capacity and Dynamic Accessibility in Associative Memory Networks with Context-Dependent Neuronal and Synaptic Gating
Podlaski, W. F., Agnes, E. J., & Vogels, T. P. (2025) · Physical Review X · doi:10.1103/physrevx.15.011057 · Cited by 9 · see citing works
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Neuromodulation and memory: exploring ethical ramifications in memory modification treatment via implantable neurotechnologies
González-Márquez, C. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1282634 · Cited by 8 · see citing works
Inhibitory Fear Memory Engram in the Mouse Central Lateral Amygdala
Hou, W., Jariwala, M., Wang, K., Seewald, A., Lin, Y. Q., Liou, Y.-C., Ricci, A., Ferraguti, F., Lien, C., & Capogna, M. (2022) · Cell Reports · doi:10.1016/j.celrep.2024.114468 · Cited by 8 · see citing works
The role of GABAA receptors in hippocampus-dependent cognitive functions
Nagarajan, R., Lyu, J., George, J. C., Rudolph, U., & Engin, E. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106659 · Cited by 7 · see citing works
Impaired inhibitory processing: a new therapeutic target for autism and psychosis?
Heinze, K., Barron, H. C., Howes, E. K., Ramaswami, M., & Broome, M. R. (2020) · The British Journal of Psychiatry · doi:10.1192/bjp.2020.163 · Cited by 7 · see citing works
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Induction of excitatory brain state governs plastic functional changes in visual cortical topology
Eysel, U. T., & Jancke, D. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02730-y · Cited by 7 · see citing works
Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP
Bergoin, R., Torcini, A., Deco, G., Quoy, M., & Zamora‐López, G. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012973 · Cited by 9 · see citing works
The cognitive basis of psychosocial impact in COVID-19 pandemic. Does it encircle the default mode network of the brain? A pragmatic proposal.
Dubey, S., Dubey, M. J., Ghosh, R., Mitchell, A. J., Chatterjee, S., Das, S., Pandit, A., Ray, B. K., Das, G. C., & León, J. (2022) · Medical Research Archives · doi:10.18103/mra.v10i3.2707 · Cited by 7 · see citing works
Integration of event experiences to build relational knowledge in the human brain
Leshinskaya, A., Nguyen, M., & Ranganath, C. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad260 · Cited by 8 · see citing works
Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity
Gallinaro, J. V., & Claudia Clopath, A. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009593 · Cited by 7 · see citing works
Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
Sawamura, H., Taniguchi, K., Ikeda, Y., Tsuji, A., Kitagishi, Y., & Matsuda, S. (2022) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2022.00019 · Cited by 7 · see citing works
Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortexPreprint
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Authors: Barron, H. C., Vogels, T. P., Behrens, T. E., & Ramaswami, M.
Affiliations: University of Oxford (GB)
Wellcome Centre for Human Neuroimaging (GB)
Tata Institute of Fundamental Research (IN)
ORCID: Barron, Helen C.
Vogels, Tim P.
Behrens, Timothy E.
Ramaswami, Mani
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-06-13
Volume: 114
Issue: 26
Pages: 6666-6674
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1701812114
PMC: PMC5495250
OpenAlex: W2626706140
Cited by: 147
References: 91
Citations by year: 2026: 17 · 2025: 17 · 2024: 23 · 2023: 12 · 2022: 22 · 2021: 17 · 2020: 17 · 2019: 10 · 2018: 11 · 2017: 1
FWCI: 1.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 183 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: John Fell Fund, University of Oxford (John Fell OUP Research Fund) (153/046)
Wellcome Trust (WT100000, WT104765MA)
James S. McDonnell Foundation (JSMF) (JSMF220020372)
Science Foundation Ireland (SFI) (15/IA/3123)
Department of Atomic Energy, Government of India (DAE) (Core Funds to TIFR/NCBS)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: memory engrams, cell assemblies, habituation, latent memory, disinhibition, perception, excitation-inhibition balance, autism spectrum disorder, schizophrenia, post-traumatic stress disorder, transdiagnostic traits
MeSH terms: Animals, Autistic Disorder, Cognition, Humans, Memory, Models, Neurological, Nerve Net, Perception, Schizophrenia, Stress Disorders, Post-Traumatic

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