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Cited by 284

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

The Orbitofrontal Cortex and Ventral Tegmental Area Are Necessary for Learning from Unexpected Outcomes

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Takahashi, Yuji K., Roesch, Matthew R., Stalnaker, Thomas A., Haney, Richard Z., Calu, Donna J., Taylor, Adam R., Burke, Kathryn A., Schoenbaum, Geoffrey·2009·Neuron
DOI 10.1016/j.neuron.2009.03.005
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Abstract

SUMMARY Humans and other animals change their behavior in response to unexpected outcomes. The orbitofrontal cortex (OFC) is implicated in such adaptive responding, based on evidence from reversal tasks. Yet these tasks confound using information about expected outcomes with learning when those expectations are violated. OFC is critical for the former function; here we show it is also critical for the latter. In a Pavlovian over-expectation task, inactivation of OFC prevented learning driven by unexpected outcomes, even when performance was assessed later. We propose this reflects a critical contribution of outcome signaling by OFC to encoding of reward prediction errors elsewhere. In accord with this proposal, we report that signaling of reward predictions by OFC neurons was related to signaling of prediction errors by dopamine neurons in ventral tegmental area (VTA). Furthermore, bilateral inactivation of VTA or contralateral inactivation of VTA and OFC disrupted learning driven by unexpected outcomes.

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Research works printed but not linked: 30

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Cited by

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Metadata

Authors
Takahashi, Y. K., Roesch, M. R., Stalnaker, T. A., Haney, R. Z., Calu, D. J., Taylor, A. R., Burke, K. A., & Schoenbaum, G.
Venue
Neuron
Publisher
Elsevier BV
Published
2009-04
Volume
62
Issue
2
Pages
269-280
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2009.03.005
OpenAlex
W2092935454
Cited by
284
References
16
FWCI
10.51
Type
journal article
Language
en
Open access
bronze
Licence

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Takahashi, Y. K., Roesch, M. R., Stalnaker, T. A., Haney, R. Z., Calu, D. J., Taylor, A. R., Burke, K. A., & Schoenbaum, G. (2009). The Orbitofrontal Cortex and Ventral Tegmental Area Are Necessary for Learning from Unexpected Outcomes. Neuron. https://doi.org/10.1016/j.neuron.2009.03.005

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