Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards
Open accessAbstract
The dopamine system is thought to be involved in making decisions about reward. Here we recorded from the ventral tegmental area in rats learning to choose between differently delayed and sized rewards. As expected, the activity of many putative dopamine neurons reflected reward prediction errors, changing when the value of the reward increased or decreased unexpectedly. During learning, neural responses to reward in these neurons waned and responses to cues that predicted reward emerged. Notably, this cue-evoked activity varied with size and delay. Moreover, when rats were given a choice between two differently valued outcomes, the activity of the neurons initially reflected the more valuable option, even when it was not subsequently selected.
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Phasic activity of dopamine neurons in the ventral tegmental area encodes a reward prediction error.
“A seminal finding was that phasic activity of dopamine neurons in the ventral tegmental area (VTA) encodes a reward prediction error (the difference between the expected and actual reward) (Schultz et al., 1997; Schultz, 1998; Roesch et al., 2007).”
From Decision Making in Recurrent Neuronal Circuits (2008) · cites this paper as Roesch et al., 2007
Spiking activity of dopamine neurons increases with both reward magnitude and probability.
“Consistent with a prediction error signal, spiking activity of dopamine neurons increases with both reward magnitude and probability (Fiorillo et al., 2003; Tobler et al., 2005; Roesch et al., 2007).”
From Decision Making in Recurrent Neuronal Circuits (2008) · cites this paper as Roesch et al., 2007
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- Authors
- Roesch, M. R., Calu, D. J., & Schoenbaum, G.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Roesch, Matthew R
- Venue
- Nature Neuroscience
- Published
- 2007-11-18
- Volume
- 10
- Issue
- 12
- Pages
- 1615-1624
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2562672
- OpenAlex
- W2040418090
- Cited by
- 597
- References
- 48
- Citations by year
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- FWCI
- 14.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG027097)
- National Institute of Mental Health (F31MH080514, F31-MH085014)
- National Institute on Drug Abuse (R01DA015718, K01DA021609)
- National Institute of Neurological Disorders and Stroke (T32 NS07375, T32NS007375)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dopaminergic neurons, ventral tegmental area, reward prediction error, decision-making, reward magnitude, reward delay, choice behavior, rats
- MeSH terms
- Action Potentials, Analysis of Variance, Animals, Apomorphine, Behavior, Animal, Brain Mapping, Choice Behavior, Conditioning, Operant, Cues, Dopamine, Male, Neurons, Odorants, Predictive Value of Tests, Reward, Time Perception, Ventral Tegmental Area, Dopamine Agonists, Rats, Long-Evans, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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