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Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation
Open accessAbstract
Recently, investigation of new neurons in memory formation has focused on a specific function-pattern separation. However, it has been difficult to reconcile the form of separation tested in behavioral tasks with how it is conceptualized according to computational and electrophysiology perspectives. Here, we propose a memory resolution hypothesis that considers the unique information contributions of broadly tuned young neurons and highly specific mature neurons and describe how the fidelity of memories can relate to spatial and contextual discrimination. See the related Perspective from Sahay, Wilson, and Hen, "Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb," in this issue of Neuron.
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“Yet, hippocampal adult neurogenesis is required for learning and memory, in particular for pattern separation, i.e., the ability to disentangle similar memory patterns within the output to CA3; indeed this ability, although inherent to the dentate gyrus circuitry, is strongly enhanced from the addition of new neurons to the existing circuits (Aimone et al., 2011;Sahay et al., 2011;Tirone et al., 2”
From Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise (2018) · cites this paper as Aimone et al., 2011
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“The dentate gyrus (DG) subregion of the hippocampus mediates episodic memory formation and the disambiguation of similar but discrete events, a phenomenon known as pattern separation [3], [4], [5], [6].”
From Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development (2012) · cites this paper as [4]
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“This primarily occurs through the role that neurogenesis plays in facilitating memory formation by dictating a computational mechanism known as pattern separation (Aimone et al., 2011; Sahay et al., 2011).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Aimone et al., 2011
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Neural networks and physical systems with emergent collective computational abilities.
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“(D) Example of in vivo electrophysiology pattern separation. responding to multiple contexts, separating by ''rate coding'' instead of ''population coding'' (Alme et al., 2010; Leutgeb et al., 2007; Figure 1D).”
BackgroundIncreasing adult hippocampal neurogenesis is sufficient to improve pattern separation
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“Recently, compelling evidence suggests that hippocampal neurogenesis is a critical factor determining the competence of pattern separation (Aimone et al., 2011; Yassa and Stark, 2011; Sahay et al., 2011a; Nakashiba et al., 2012).”
BackgroundPerspectives for computational modeling of cell replacement for neurological disorders
Aimone, J. B., & Weick, J. P. (2013) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2013.00150 · Cited by 15
“As a result, sharpening RFs over time could be beneficial (O’Reilly and McClelland, 1994; Aimone et al., 2011).”
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“Neurogenesis is found in the DG in the adult brain, and these newborn cells can mature into functional neurons and play a role in maintaining hippocampal function (Aimone et al., 2011; Altman and Bayer, 1990; Clelland et al., 2009; Gage, 2002; Kempermann et al., 2004; Van Praag et al., 2002).”
A Combinatorial Model for Dentate Gyrus Sparse Coding
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“Rather, because of the essentially unbounded range of novel inputs; it is far more effective to ensure against these with more scaling friendly “immature” neurons (Aimone et al., 2011).”
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“It is regarded as a key feature of the ability to distinguish between similar places/situations/contexts/events, i.e., context discrimination, and was named the resolution of the memory (Aimone et al., 2011).”
BackgroundDistinguishing examples while building concepts in hippocampal and artificial networks
Kang, L., & Toyoizumi, T. (2024) · Nature Communications · doi:10.1038/s41467-024-44877-0 · Cited by 16
Adult Neurogenesis in the Dentate Gyrus
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Self-citationHow Does the Brain Solve the Computational Problems of Spatial Navigation?
Widloski, J., & Fiete, I. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1292-2_14 · Cited by 12
“IF is a Sloan Foundation Fellow, a Searle Scholar, a McKnight Scholar, and acknowledges funding from the Office of Naval Research, through ONR MURI award N00014-10-1-0936.”
BackgroundDifferential Involvement of the Dentate Gyrus in Adaptive Forgetting in the Rat
Joseph, M. A., Fraize, N., Ansoud-Lerouge, J., Sapin, E., Peyron, C., Arthaud, S., Libourel, P., Parmentier, R., Salin, P. A., & Malleret, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142065 · Cited by 12
“Our results suggest that processing interference in a WM task could specifically require an inhibition of the DG, a site where adult neurogenesis is known to occur [37, 38].”
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A functional model of adult dentate gyrus neurogenesis
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Multifaceted circuit functions of adult-born neurons
Dieni, C. V., Gonzalez, J., & Overstreet-Wadiche, L. (2019) · F1000Research · doi:10.12688/f1000research.20642.1 · Cited by 8
Hippocampal neurogenesis facilitates cognitive flexibility in a fear discrimination task
Martínez-Canabal, A., López-Oropeza, G., & Sotres-Bayón, F. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1331928 · Cited by 11
Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory
Wang, J., Song, L., Zhang, Q., Zhang, W., An, L., Zhang, Y., Tong, D., Zhao, B., Chen, S., & Zhao, S. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.11.017 · Cited by 12
Cerveau et mémoire : des nouveaux neurones pour se souvenir
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“In our study, we found that CPA induced an increased BDNF expression in the BLA and hippocampal DG, two limbic areas that play a critical role in emotional learning and memory.(8,9) The increased expression of BDNF observed after CPA in DG and BLA was accompanied by the activation of the HPA axis resulting in an enhan…”
BackgroundCeccarelli, M., D’Andrea, G., Micheli, L., & Tirone, F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00211 · Cited by 11
“Hippocampal adult neurogenesis is necessary for learning and memory, as it contributes to enhance the ability to distinguish between similar memory patterns; this ability, defined pattern separation, is in-built in the dentate gyrus circuitry, but is greatly improved by the addition of new neurons to the existent circ…”
BackgroundMcNerlin, C., Guan, F., Bronk, L., Lei, K., Grosshans, D., Young, D. W., Gaber, M. W., & Maletic-Savatic, M. (2022) · Life Sciences in Space Research · doi:10.1016/j.lssr.2022.07.007 · Cited by 11
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“The issue appears to be important especially when considering that cognitive and emotional tasks occur in the neurogenic areas (Aimone et al., 2011; Ming and Song, 2011; Miller and Hen, 2015), and that altered adult neurogenesis and hyppocampal lesions have been repeatedly related to…”
BackgroundDifferential development of relational memory and pattern separation
Hassevoort, K. M., Khan, N. A., Hillman, C. H., & Cohen, N. J. (2019) · Hippocampus · doi:10.1002/hipo.23146 · Cited by 10
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“The best studied are spatial learning and memory (Deng et al., 2010; Aimone et al., 2011).”
BackgroundMaturational phase of hippocampal neurogenesis and cognitive flexibility
Webler, R. D., Fulton, S. L., Perera, T. D., & Coplan, J. D. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134414 · Cited by 10
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“Adult neurogenesis is the process of continuous generation of newborn neurons and their subsequent integration into the pre-existing circuits [12,13].”
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“Pattern separation has been essentially ascribed to the DG (Aimone et al., 2011; Kesner and Rolls, 2015; Marr, 1971; Schmidt et al., 2012) and has been well modeled in the entorhinal cortex (EC)-DG network.”
BackgroundMethodBento‐Torres, J., Sobral, L. L., dos Reis, R. R., de Oliveira, R. B., Anthony, D. C., Vasconcelos, P. F. D. C., & Diniz, C. W. P. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4504925 · Cited by 10
“The integrity of theDGbut not theCA1 is essential to the discrimination of similar objects in different contexts [58].”
BackgroundDUSP6 Deficiency Attenuates Neurodegeneration after Global Cerebral Ischemia
Weng, Y., Huang, Y., Chiang, I., Chuang, H., Lee, T., Tan, T., & Chou, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097690 · Cited by 9
“The functional role of the hippocampus in spatial learning and memory has been established [23,24].”
BackgroundHersman, S., Barrera, V. R., & Fanselow, M. S. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00182 · Cited by 9
“Again, concrete hypotheses can help to use these factors to test how these adult-born neurons work differently from their neighbors.”
BackgroundInfluentialNeurogenesis Enhances Response Specificity to Spatial Pattern Stimulation in Hippocampal Cultures
Tanaka, Y., Isomura, T., Shimba, K., Kotani, K., & Jimbo, Y. (2016) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2016.2639468 · Cited by 9
“It was recently hypothesized that immature neurons increase the memory resolution of neural networks as a mechanism to improve subsequent pattern separation [24].”
BackgroundDeng, D., Jian, C., Lei, L., Zhou, Y., McSweeney, C., Dong, F., Shen, Y., Zou, D., Wang, Y., Wu, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21381 · Cited by 9
“Adult neurogenesis in the DG plays an important role in memory and depression [53-57].”
BackgroundDentate Granule Cells Recruited in the Home Environment Display Distinctive Properties
Pléau, C., Peret, A., Pearlstein, É., Scalfati, T., Vigier, A., Marti, G., Michel, F. J., Marissal, T., & Crépel, V. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.609123 · Cited by 9
“Since the discovery of the DG’s ability to generate new neurons throughout life (Aimone et al., 2011), it has been proposed that DG neurogenesis provides a substrate for spatial memory and pattern separation (McNaughton andMorris, 1987; Leutgeb et al., 2007; Clelland et al., 2009; Aimone et al.,…”
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An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury
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“, 2010; Ming and ong, 2011), the formation of new memories (Aimone et al., 2011; lelland et al., 2009; Zhang et al., 2008) and the regulation of anxity behavior (Saxe et al.”
BackgroundHopfield-like network with complementary encodings of memories
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“…exposure, showed that granule cell neuron populations responded to odour stimuli (Jung and McNaughton, 1993; Ramίrez-Amaya et al., 2005), with the activation capable of contributing to an encoding of memories and neural plasticity (Kee et al., 2007; Hunsaker and Kesner, 2008; Aimone et al., 2011).”
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In the pursuit of new social neurons. Neurogenesis and social behavior in mice: A systematic review
García-Gómez, L., Castillo-Fernández, I., & Pérez‐Villalba, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1011657 · Cited by 8
“In rodents, cognitive and emotional variables have been repeatedly correlated with variations in adult neurogenesis (Lazarini et al., 2009; Aimone et al., 2011).”
BackgroundEffect of adult-born immature granule cells on pattern separation in the hippocampal dentate gyrus
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“2, as a result of increased leakage reversal potential V L , the imGC has lower firing threshold than the mGC (i.e., high excitability), which results in high activation of the imGCs (Sahay et al. 2011a, b; Aimone et al. 2011, 2009, 2010; Dieni et al. 2016; Finnegan and Becker 2015).”
InfluentialCharacterization of a population of neural progenitor cells in the infant hippocampus
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“Therefore, interindividual differences in these morphological traits may well lead to define the distinct individual efficacy in performing different tasks (see for example Aimone et al., 2011; Nakashiba et al., 2012; Lacar et al., 2014).”
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Self-citationThe Contribution of Adult Hippocampal Neurogenesis to the Progression of Psychiatric Disorders
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Quantifying neural information content: A case study of the impact of hippocampal adult neurogenesis
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“Rather, the DG likely needs to maintain a balance between information coding and separation; effectively minimizing correlation between DG outputs is likely best thought of as a constraint as opposed to a function in and of itself [10].”
BackgroundSelf-citationDiscrimination of mnemonic similarity is associated with short-term and long-term memory precision
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“Although the link between pattern separation and memory precision is frequently assumed (Aimone et al., 2011), there remains a lack of behavioral evidence directly supporting this conjecture.”
Allopregnanolone as a Therapeutic to Regenerate the Degenerated Brain
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Being a Neural Stem Cell: A Matter of Character But Defined by the Microenvironment
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“Neurogenesis (particularly in the SGZ) plays important roles in several adult brain processes, such as memory formation and extinction, pattern separation in memory, learning and cognition, and potentiation of antidepressant efficacy (Shors et al. 2001; Zhao et al. 2008; Aimone et al. 2011; Akers et al. 2014; Johnston…”
BackgroundRole of Lysophosphatidic Acid (LPA) in Behavioral Processes: Implications for Psychiatric Disorders
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Memory processing by hippocampal adult-born neurons
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“The finite duration of this high-plasticity window may allow the hippocampus to integrate new information without destabilization of pre-existing networks (Aimone et al., 2011).”
Nam, A. J., Kuwajima, M., Parker, P. H., Bowden, J. B., Abraham, W. C., & Harris, K. M. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0943-25.2025 · Cited by 6
The role of GABAA receptors in hippocampus-dependent cognitive functions
Nagarajan, R., Lyu, J., George, J. C., Rudolph, U., & Engin, E. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106659 · Cited by 8
Weston, N. M., Green, J. C., Keoprasert, T. N., & Sun, D. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114963 · Cited by 7
NICE: Neurogenesis Inspired Contextual Encoding for Replay-free Class Incremental Learning
Gürbüz, M. B., Moorman, J. M., & Dovrolis, C. (2024) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr52733.2024.02233 · Cited by 6
“This process continuously introduces adult-born granule cells into the dentate gyrus, providing a unique form of plasticity not found in most other brain regions [2, 3, 46].”
López-Oropeza, G., Durán, P., & Martínez-Canabal, A. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.971359 · Cited by 5
“in distinct cognitive tasks, like pattern separation (Aimone et al., 2011), episodic-like memory forgetting (Feng et al.”
BackgroundMetabolic regulation of adult stem cell-derived neurons
Beckervordersandforth, R., Häberle, B. M., & Lie, D. C. (2015) · Frontiers in Biology · doi:10.1007/s11515-015-1351-5 · Cited by 6
“Impairment of adult hippocampal neurogenesis is suggested to contribute to learning and memory deficits and mood disturbances in neurodegenerative and neuropsychiatric disorders (Aimone et al., 2011; Sahay et al., 2011; Winner et al., 2011; Kheirbek et al., 2012).”
BackgroundPattern Separation: A Key Processing Deficit Associated with Aging?
Gilbert, P. E., Holden, H. M., Sheppard, D. P., & Morris, A. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-15759-7_5 · Cited by 6
Pattern separation and goal-directed behavior in the aged caninePreprint
Snigdha, S., Yassa, M. A., de Rivera, C., Milgram, N. W., & Cotman, C. W. (2017) · Learning & Memory · doi:10.1101/lm.043422.116 · Cited by 6
Attention-Based Structural-PlasticityPreprint
Kolouri, S., Ketz, N., Zou, X., Krichmar, J. L., & Pilly, P. K. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1903.06070 · Cited by 6
“The second strategy is based on similar ideas to neurogenesis in the brain (Aimone et al., 2011).”
Micheli, L., Caruso, M., D’Andrea, G., Volpe, D., Ceccarelli, M., & Tirone, F. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1605116 · Cited by 6
“…memory, specifically for pattern separation - i.e., the capacity to distinguish between similar memory patterns - which is a function of dentate gyrus circuitry enhanced by the addition of new neurons to existing circuits (Aimone et al., 2011; Sahay et al., 2011; Farioli-Vecchioli et al., 2008).”
Medial temporal lobe lesions reduce visual working memory precision
Choo, Y., Thakurdesai, S., Qadri, A., Fruchet, O., Jackson, S. N., Chatterjee, R., Inati, S. K., Zaghloul, K. A., & Xie, W. (2025) · Brain · doi:10.1093/brain/awaf397 · Cited by 9
Neurophotonics Approaches for the Study of Pattern Separation
Morales, C., Morici, J. F., Miranda, M., Gallo, F. T., Bekinschtein, P., & Weisstaub, N. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00026 · Cited by 5
A Model of Pattern Separation by Single Neurons
Löffler, H., & Gupta, D. S. (2022) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2022.858353 · Cited by 5
“Expansion recoding, sparse synaptic connectivity to the output neurons, and Winner Takes All (WTA) competition through inhibition have so far mainly been considered as relevant mechanisms for spatial pattern separation: Marr (1971), O’Reilly and McClelland (1994), Chistiakova and Volgushev (2009), Aimone et al. (2011)…”
BackgroundNeuron-based heredity and human evolution
Gash, D. M., & Deane, A. S. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00209 · Cited by 15
Animal Models of Exercise–Brain Interactions
Hamilton, G. F., & Rhodes, J. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800778-5.00003-7 · Cited by 5
Purposeful Activity in Psychiatric Rehabilitation: Is Neurogenesis a Key Player?
Cheung, J. S.-C., Chan, J. N.-M., Lau, B. W.-M., & Ngai, S. P. C. (2016) · Hong Kong Journal of Occupational Therapy · doi:10.1016/j.hkjot.2016.04.002 · Cited by 5
Kirschen, G. W., Antonio, A. D., & Ge, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801977-1.00002-7 · Cited by 5
Dynamics of Cognitive Functions in Patients With Parasellar Meningiomas Undergoing Radiotherapy
Alekseeva, A. S., Enikolopova, E. V., Андреевна, К. О., Danilov, G., & Галкин, М. В. (2018) · KnE Life Sciences · doi:10.18502/kls.v4i8.3261 · Cited by 5
“Since arising as a purely computational hypothesis a decade ago, this concept received substantial experimental support from different groups, employing various behavioral models [7].”
BackgroundAronowitz, J. V., Perez, A., OʼBrien, C., Aziz, S., Rodriguez, E., Wasner, K., Ribeiro, S. P., Green, D., Faruk, F., & Pytte, C. L. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256709 · Cited by 5
“…the motor resolution for song production borrows from the model that new neurons in the rodent hippocampus contribute to memory resolution, providing improved pattern separation (Aimone et al., 2011) and suggests a potential general rule of new neuron function in widely different substrates.”
BackgroundBird, A. D., Cuntz, H., & Jedlička, P. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010706 · Cited by 10
In Vivo Quantification of White Matter Pathways in the Human Hippocampus
Gumus, M., Bourganos, A., & Mack, M. L. (2025) · Human Brain Mapping · doi:10.1002/hbm.70417 · Cited by 4
“These structures are recruited during many cognitive functions (Aimone et al. 2011; Leutgeb et al. 2007; O'Reilly et al. 2014) as information travels within the hippocampal pathways connecting the subfields and ERC (Anand and Dhikav 2012).”
Early deficits in dentate circuit and behavioral pattern separation after concussive brain injury
Corrubia, L., Huang, A., Nguyen, S. T., Shiflett, M. W., Jones, M. V., Ewell, L. A., & Santhakumar, V. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114578 · Cited by 4
“…dentate gyrus, and particularly the ongoing generation of adult-born neurons in the dentate, has been shown to play a role in stratification of memories over the time course of weeks (Clelland et al., 2009; Aimone et al., 2011; Nakashiba et al., 2012; Rangel et al., 2014; Miller and Sahay, 2019).”
Koehl, M., Ladevèze, E., Montcouquiol, M., & Abrous, D. N. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.844255 · Cited by 4
Chandwani, M. N., Kamte, Y. S., Singh, V. R., Hemerson, M. E., Michaels, A. C., Leak, R. K., & O’Donnell, L. A. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.07.008 · Cited by 4
The Role of the Hippocampus in the Perception and Recall of Odors. A Hypothetical Neural Mechanism
Silkis, I. G. (2023) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-023-01521-6 · Cited by 3
“…hippocampal neural networks helps explain why the hippocampus is involved in both odor perception and memory for events (scenes) granule cells in the OB and DG appearing during neurogenesis can function as modulators of the activity of existing neurons and in fl uence pattern discrimination [6, 92].”
BackgroundFauré, L. M. P., Gauzin, S., Lejards, C., Rampon, C., & Verret, L. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106799 · Cited by 5
Ong, J. Y., Wu, Q., Sasaki, K., Isoda, H., & Szele, F. G. (2025) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szaf006 · Cited by 4
“18,19 Injury-induced functions of adult neurogenesis Brain injury induces adult neurogenesis which can efficiently repair damage in nonmammalian species such as fish and reptiles.”
Borgmann, F. B. K., Gräff, J., Mansuy, I. M., Toni, N., & Jessberger, S. (2016) · Matters Select · doi:10.19185/matters.201610000014 · Cited by 4
Spatial geometry of stem cell proliferation in the adult hippocampus
Mineyeva, O. A., Enikolopov, G., & Koulakov, A. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-21078-6 · Cited by 4
Lee, H.-Y., Kang, S. W., Jeong, H., Kwon, J., Kim, Y. O., & Kim, H. (2021) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2021.19.4.618 · Cited by 4
“Adult neurogenesis in the hippocampus contributes to learning and memory [34,35], and”
BackgroundГалкин, М. В., Danilov, G., Kaverina, M. Y., Strunina, Y., & Андреевна, К. О. (2021) · Cureus · doi:10.7759/cureus.20252 · Cited by 4
“It is believed that these types of errors may be associated with a suppression of neurogenesis in the hippocampus [15,16].”
Background
Metadata
- Authors
- Aimone, J. B., Deng, W., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Gage, Fred H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 70
- Issue
- 4
- Pages
- 589-596
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3240575
- OpenAlex
- W2069785065
- Cited by
- 663
- References
- 49
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 20 · 2023: 25 · 2022: 27 · 2021: 31 · 2020: 41 · 2019: 38 · 2018: 39 · 2017: 64 · 2016: 62 · 2015: 62 · 2014: 71 · 2013: 63 · 2012: 58
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Foundation for the National Institutes of Health
- James S. McDonnell Foundation
- National Institute of Mental Health (R01MH090258)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dentate gyrus, adult neurogenesis, pattern separation, hippocampus, spatial discrimination, contextual discrimination, memory fidelity, mature neurons, memory formation
- MeSH terms
- Adult, Age Factors, Animals, Humans, Memory, Dentate Gyrus, Neurogenesis
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