Hypothalamic control of energy balance: insights into the role of synaptic plasticity
Abstract
The past 20 years witnessed an enormous leap in understanding of the central regulation of whole-body energy metabolism. Genetic tools have enabled identification of the region-specific expression of peripheral metabolic hormone receptors and have identified neuronal circuits that mediate the action of these hormones on behavior and peripheral tissue functions. One of the surprising findings of recent years is the observation that brain circuits involved in metabolism regulation remain plastic through adulthood. In this review, we discuss these findings and focus on the role of neurons and glial cells in the dynamic process of plasticity, which is fundamental to the regulation of physiological and pathological metabolic events.
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Regulation of spontaneous firing of AgRP neurons can be achieved by synaptic and intrinsic mechanisms.
“Regulation of spontaneous firing of AgRP neurons can be achieved by synaptic and intrinsic mechanisms [54, 58–61].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [59]
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Synaptic Plasticity of Feeding Circuits: Hormones and Hysteresis
Dietrich, M. O., & Horváth, T. L. (2011) · Cell · doi:10.1016/j.cell.2011.08.031 · Cited by 15 · see citing works
Self-citationPhosphoribosomes for Fingerprinting Neurons
Dietrich, M. O., & Horváth, T. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.006 · Cited by 1 · see citing works
Self-citation
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Fang, X., Jiang, S., Wang, J., Bai, Y., Kim, C. S., Blake, D., Weintraub, N. L., Lei, Y., & Lu, X.-Y. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-01004-x · Cited by 95 · see citing works
Epigenetic control and the circadian clock: Linking metabolism to neuronal responses
Orozco-Solis, R., & Sassone-Corsi, P. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.043 · Cited by 94 · see citing works
Tian, J., Guo, L., Sui, S., Driskill, C., Phensy, A., Wang, Q., Gauba, E., Zigman, J. M., Swerdlow, R. H., Kroener, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav6278 · Cited by 72 · see citing works
Harding, I. H., Andrews, Z. B., Mata, F., Orlandea, S., Martínez-Zalacaín, I., Soriano-Mas, C., Stice, E., & Verdejo-Garcia, A. (2018) · International Journal of Obesity · doi:10.1038/ijo.2017.237 · Cited by 31 · see citing works
- Authors
- Dietrich, M. O., & Horvath, T. L.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- ORCID
- Dietrich, Marcelo O.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 36
- Issue
- 2
- Pages
- 65-73
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2039711980
- Cited by
- 227
- References
- 98
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 16 · 2023: 13 · 2022: 19 · 2021: 23 · 2020: 20 · 2019: 23 · 2018: 19 · 2017: 16 · 2016: 16 · 2015: 29 · 2014: 15 · 2013: 6
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK098058)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hypothalamus, energy balance, synaptic plasticity, neural circuits, glial cells, adult neuroplasticity, metabolic hormones
- MeSH terms
- Energy Metabolism, Estriol, Humans, Hypothalamus, Neuronal Plasticity
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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