Cited by 227Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuroscience and Neuropharmacology Research

Hypothalamic control of energy balance: insights into the role of synaptic plasticity

Dietrich, Marcelo O., Horvath, Tamas L.·2013·Trends in Neurosciences

Abstract

The past 20 years witnessed an enormous leap in understanding of the central regulation of whole-body energy metabolism. Genetic tools have enabled identification of the region-specific expression of peripheral metabolic hormone receptors and have identified neuronal circuits that mediate the action of these hormones on behavior and peripheral tissue functions. One of the surprising findings of recent years is the observation that brain circuits involved in metabolism regulation remain plastic through adulthood. In this review, we discuss these findings and focus on the role of neurons and glial cells in the dynamic process of plasticity, which is fundamental to the regulation of physiological and pathological metabolic events.

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Crossref · 10.1016/j.tins.2012.12.005

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Authors
Dietrich, M. O., & Horvath, T. L.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2013-02
Volume
36
Issue
2
Pages
65-73
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2039711980
Cited by
227
References
98
Citations by year
2026: 3 · 2025: 9 · 2024: 16 · 2023: 13 · 2022: 19 · 2021: 23 · 2020: 20 · 2019: 23 · 2018: 19 · 2017: 16 · 2016: 16 · 2015: 29 · 2014: 15 · 2013: 6
FWCI
2.62
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK098058)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
hypothalamus, energy balance, synaptic plasticity, neural circuits, glial cells, adult neuroplasticity, metabolic hormones
MeSH terms
Energy Metabolism, Estriol, Humans, Hypothalamus, Neuronal Plasticity

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