Cited by 147Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuroscience and Neuropharmacology Research

Synaptic plasticity in neuronal circuits regulating energy balance

Zeltser, Lori M, Seeley, Randy J, Tschöp, Matthias H·2012·Nature Neuroscience

Abstract

Maintaining energy balance is of paramount importance for metabolic health and survival. It is achieved through the coordinated regulation of neuronal circuits that control a wide range of physiological processes affecting energy intake and expenditure, such as feeding, metabolic rate, locomotor activity, arousal, growth and reproduction. Neuronal populations distributed throughout the CNS but highly enriched in the mediobasal hypothalamus, sense hormonal, nutrient and neuronal signals of systemic energy status and relay this information to secondary neurons that integrate the information and regulate distinct physiological parameters in a manner that promotes energy homeostasis. To achieve this, it is critical that neuronal circuits provide information about short-term changes in nutrient availability in the larger context of long-term energy status. For example, the same signals lead to different cellular and physiological responses if delivered under fasted versus fed conditions. Thus, there is a clear need to have mechanisms that rapidly and reversibly adjust responsiveness of hypothalamic circuits to acute changes in nutrient availability.

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Crossref · 10.1038/nn.3219

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Authors
Zeltser, L. M., Seeley, R. J., & Tschöp, M. H.
Affiliations
  • Columbia University Irving Medical Center (US)
  • University of Cincinnati (US)
  • Helmholtz Munich (DE)
Corresponding author
Tschöp, Matthias H
Venue
Nature Neuroscience
Published
2012-09-25
Volume
15
Issue
10
Pages
1336-1342
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2039511285
Cited by
147
References
80
Citations by year
2026: 6 · 2025: 10 · 2024: 12 · 2023: 13 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 18 · 2016: 7 · 2015: 19 · 2014: 15 · 2013: 10 · 2012: 1
FWCI
1.63
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
  • Site cant be reached (submittedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089038, R01DK093848)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
synaptic plasticity, energy balance, energy homeostasis, mediobasal hypothalamus, hypothalamic circuits, nutrient availability, food intake regulation, metabolic rate, neural circuits
MeSH terms
Animals, Brain, Energy Metabolism, Hypothalamus, Models, Neurological, Neural Pathways, Synaptic Transmission, Neuronal Plasticity, Neuropeptide Y, Pro-Opiomelanocortin, Melanocortins, Agouti-Related Protein

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