Synaptic plasticity in neuronal circuits regulating energy balance
Abstract
Maintaining energy balance is of paramount importance for metabolic health and survival. It is achieved through the coordinated regulation of neuronal circuits that control a wide range of physiological processes affecting energy intake and expenditure, such as feeding, metabolic rate, locomotor activity, arousal, growth and reproduction. Neuronal populations distributed throughout the CNS but highly enriched in the mediobasal hypothalamus, sense hormonal, nutrient and neuronal signals of systemic energy status and relay this information to secondary neurons that integrate the information and regulate distinct physiological parameters in a manner that promotes energy homeostasis. To achieve this, it is critical that neuronal circuits provide information about short-term changes in nutrient availability in the larger context of long-term energy status. For example, the same signals lead to different cellular and physiological responses if delivered under fasted versus fed conditions. Thus, there is a clear need to have mechanisms that rapidly and reversibly adjust responsiveness of hypothalamic circuits to acute changes in nutrient availability.
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- Authors
- Zeltser, L. M., Seeley, R. J., & Tschöp, M. H.
- Affiliations
- Columbia University Irving Medical Center (US)
- University of Cincinnati (US)
- Helmholtz Munich (DE)
- Corresponding author
- Tschöp, Matthias H
- Venue
- Nature Neuroscience
- Published
- 2012-09-25
- Volume
- 15
- Issue
- 10
- Pages
- 1336-1342
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2039511285
- Cited by
- 147
- References
- 80
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 12 · 2023: 13 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 18 · 2016: 7 · 2015: 19 · 2014: 15 · 2013: 10 · 2012: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089038, R01DK093848)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- synaptic plasticity, energy balance, energy homeostasis, mediobasal hypothalamus, hypothalamic circuits, nutrient availability, food intake regulation, metabolic rate, neural circuits
- MeSH terms
- Animals, Brain, Energy Metabolism, Hypothalamus, Models, Neurological, Neural Pathways, Synaptic Transmission, Neuronal Plasticity, Neuropeptide Y, Pro-Opiomelanocortin, Melanocortins, Agouti-Related Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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