Leptin Modulates the Intrinsic Excitability of AgRP/NPY Neurons in the Arcuate Nucleus of the Hypothalamus
Open accessAbstract
The hypothalamic arcuate nucleus (ARH) is a brain region critical for regulation of food intake and a primary area for the action of leptin in the CNS. In lean mice, the adipokine leptin inhibits neuropeptide Y (NPY) and agouti-related peptide (AgRP) neuronal activity, resulting in decreased food intake. Here we show that diet-induced obesity in mice is associated with persistent activation of NPY neurons and a failure of leptin to reduce the firing rate or hyperpolarize the resting membrane potential. However, the molecular mechanism whereby diet uncouples leptin's effect on neuronal excitability remains to be fully elucidated. In NPY neurons from lean mice, the Kv channel blocker 4-aminopyridine inhibited leptin-induced changes in input resistance and spike rate. Consistent with this, we found that ARH NPY neurons have a large, leptin-sensitive delayed rectifier K + current and that leptin sensitivity of this current is blunted in neurons from diet-induced obese mice. This current is primarily carried by Kv2-containing channels, as the Kv2 channel inhibitor stromatoxin-1 significantly increased the spontaneous firing rate in NPY neurons from lean mice. In HEK cells, leptin induced a significant hyperpolarizing shift in the voltage dependence of Kv2.1 but had no effect on the function of the closely related channel Kv2.2 when these channels were coexpressed with the long isoform of the leptin receptor LepRb. Our results suggest that dynamic modulation of somatic Kv2.1 channels regulates the intrinsic excitability of NPY neurons to modulate the spontaneous activity and the integration of synaptic input onto these neurons in the ARH.
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AgRP neurons are inhibited by overfeeding and satiety signals.
“and inhibited by overfeeding and satiety signals [23–25].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [24]
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Cites
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679 · see citing works
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578 · see citing works
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,518 · see citing works
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,238 · see citing works
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
Aponte, Y., Atasoy, D., & Sternson, S. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2739 · Cited by 1,157 · see citing works
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,127 · see citing works
Mechanisms of leptin action and leptin resistance.
Myers, M. G., Cowley, M. A., & Münzberg, H. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100707 · Cited by 1,074 · see citing works
Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
Pinto, S., Roseberry, A. G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J. M., & Horvath, T. L. (2004) · Science · doi:10.1126/science.1089459 · Cited by 987 · see citing works
Deconstruction of a neural circuit for hunger
Atasoy, D., Betley, J. N., Su, H. H., & Sternson, S. M. (2012) · Nature · doi:10.1038/nature11270 · Cited by 969 · see citing works
Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area
Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbæk, C., Flier, J. S., Saper, C. B., & Elmquist, J. K. (1999) · Neuron · doi:10.1016/s0896-6273(01)80035-0 · Cited by 924 · see citing works
Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
Rudy, B., & McBain, C. J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01892-0 · Cited by 781 · see citing works
Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737 · see citing works
Self-citationLeptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D., & Ashford, M. L. J. (1997) · Nature · doi:10.1038/37379 · Cited by 628 · see citing works
Diet-Induced Obesity Causes Severe but Reversible Leptin Resistance in Arcuate Melanocortin Neurons
Enriori, P. J., Evans, A. E., Sinnayah, P., Jobst, E. E., Tonelli-Lemos, L., Billes, S. K., Glavas, M. M., Grayson, B. E., Perello, M., Nillni, E. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.004 · Cited by 552 · see citing works
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J. (2000) · Nature Neuroscience · doi:10.1038/77660 · Cited by 495 · see citing works
Pharmacology of cardiac potassium channels
Tamargo, J. L. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.026 · Cited by 466 · see citing works
Regulation of ion channel localization and phosphorylation by neuronal activity
Misonou, H., Mohapatra, D. P., Park, E. W., Leung, V. C. M., Zhen, D., Misonou, K., Anderson, A. E., & Trimmer, J. S. (2004) · Nature Neuroscience · doi:10.1038/nn1260 · Cited by 464 · see citing works
Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
van den Top, M., Lee, K., Whyment, A. D., Blanks, A. M., & Spanswick, D. (2004) · Nature Neuroscience · doi:10.1038/nn1226 · Cited by 435 · see citing works
Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
Yang, Y., Atasoy, D., Su, H. H., & Sternson, S. M. (2011) · Cell · doi:10.1016/j.cell.2011.07.039 · Cited by 431 · see citing works
Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity
Shanley, L. J., Irving, A. J., & Harvey, J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-j0001.2001 · Cited by 416 · see citing works
Takahashi, K. A., & Cone, R. D. (2005) · Endocrinology · doi:10.1210/en.2004-1397 · Cited by 308 · see citing works
Liu, T., Kong, D., Shah, B. P., Ye, C., Koda, S., Saunders, A., Ding, J. B., Yang, Z., Sabatini, B. L., & Lowell, B. B. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.027 · Cited by 296 · see citing works
Diano, S., Liu, Z.-W., Jeong, J. K., Dietrich, M. O., Ruan, H., Kim, E., Suyama, S., Kelly, K., Gyengési, E., Arbiser, J. L., et al. (2011) · Nature Medicine · doi:10.1038/nm.2421 · Cited by 268 · see citing works
Pharmacology of neuronal background potassium channels
Lesage, F. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00339-8 · Cited by 259 · see citing works
Leptin receptor signaling and the regulation of mammalian physiology
Villanueva, E. C., & Myers, M. G. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.232 · Cited by 231 · see citing works
van den Pol, A. N., Yao, Y., Fu, L., Foo, K. S., Huang, H., Coppari, R., Lowell, B. B., & Broberger, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3249-08.2009 · Cited by 221 · see citing works
Du, J., Laurel, H., Phillips‐Tansey, E., Russell, J. T., & McBain, C. J. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-2-00019.xm · Cited by 214 · see citing works
Misonou, H., Mohapatra, D. P., Menegola, M., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3370-05.2005 · Cited by 190 · see citing works
Escoubas, P., Diochot, S., Célérier, M., Nakajima, T., & Lazdunski, M. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.48 · Cited by 190 · see citing works
Alteration and restoration of K+ channel function by deletions at the N- and C-termini
VanDongen, A. M. J., Frech, G. C., Drewe, J. A., Joho, R. H., & Brown, A. M. (1990) · Neuron · doi:10.1016/0896-6273(90)90082-q · Cited by 185 · see citing works
Kv2.1 Ablation Alters Glucose-Induced Islet Electrical Activity, Enhancing Insulin Secretion
Jacobson, D. A., Kuznetsov, A., Lopez, J. P., Kash, S., Ämmälä, C. E., & Philipson, L. H. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.07.010 · Cited by 180 · see citing works
Mirshamsi, S., Laidlaw, H. A., Ning, K., Anderson, E., Burgess, L. A., Gray, A., Sutherland, C., & Ashford, M. L. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-54 · Cited by 173 · see citing works
Bouret, S. G., Bates, S. H., Chen, S. H., Myers, M. G., & Simerly, R. B. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2277-11.2012 · Cited by 144 · see citing works
Targeting of voltage-gated potassium channel isoforms to distinct cell surface microdomains
O’Connell, K. M. S., & Tamkun, M. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02348 · Cited by 122 · see citing works
Self-citationO’Connell, K. M. S., Rolig, A. S., Whitesell, J. D., & Tamkun, M. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1825-06.2006 · Cited by 119 · see citing works
Self-citationLocalization-dependent activity of the Kv2.1 delayed-rectifier K + channel
O’Connell, K. M. S., Loftus, R. J., & Tamkun, M. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003028107 · Cited by 115 · see citing works
Self-citationBidirectional Activity-Dependent Regulation of Neuronal Ion Channel Phosphorylation
Misonou, H., Menegola, M., Mohapatra, D. P., Guy, L. K., Park, K.-S., & Trimmer, J. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3970-06.2006 · Cited by 110 · see citing works
Mohapatra, D. P., & Trimmer, J. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4620-05.2006 · Cited by 105 · see citing works
Mohapatra, D. P., Misonou, H., Sheng-Jun, P., Held, J. E., Surmeier, D. J., & Trimmer, J. S. (2009) · Channels · doi:10.4161/chan.3.1.7655 · Cited by 96 · see citing works
Leptin Stimulates Both JAK2-dependent and JAK2-independent Signaling Pathways
Jiang, L., Li, Z., & Rui, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805545200 · Cited by 94 · see citing works
Hernandez-Pineda, R., Chow, A., Amarillo, Y., Moreno, H., Saganich, M. J., de Miera, E. V., Hernández‐Cruz, A., & Rudy, B. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.3.1512 · Cited by 92 · see citing works
The Acute Effects of Leptin Require PI3K Signaling in the Hypothalamic Ventral Premammillary Nucleus
Williams, K. W., Sohn, J., Donato, J., Lee, C. E., Zhao, J. J., Elmquist, J. K., & Elias, C. F. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2602-11.2011 · Cited by 82 · see citing works
Fasting and 17β-Estradiol Differentially Modulate the M-Current in Neuropeptide Y Neurons
Roepke, T. A., Qiu, J., Smith, A. W., Rønnekleiv, O. K., & Kelly, M. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1395-11.2011 · Cited by 80 · see citing works
El-kholy, W., MacDonald, P. E., Lin, J., Wang, J., Fox, J. M., Light, P. E., Wang, Q., Tsushima, R. G., & Wheeler, M. B. (2003) · The FASEB Journal · doi:10.1096/fj.02-0802fje · Cited by 77 · see citing works
Leptin Enhances the Potency of Circulating Angiogenic Cells Via Src Kinase and Integrin αvβ5
Heida, N.-M., Leifheit‐Nestler, M., Schroeter, M. R., Müller, J.-P., Cheng, I., Henkel, S., Limbourg, A., Limbourg, F. P., Alves, F., Quigley, J. P., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.192807 · Cited by 71 · see citing works
A mechanism for homeostatic plasticity
Surmeier, D. J., & Foehring, R. C. (2004) · Nature Neuroscience · doi:10.1038/nn0704-691 · Cited by 66 · see citing works
Tiran, Z., Peretz, A. S., Attali, B., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212766200 · Cited by 63 · see citing works
Formation of Heteromeric Kv2 Channels in Mammalian Brain Neurons
Kihira, Y., Hermanstyne, T. O., & Misonou, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074260 · Cited by 60 · see citing works
Mohapatra, D. P., Siino, D. F., & Trimmer, J. S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0186-08.2008 · Cited by 49 · see citing works
Analysis and functional implications of phosphorylation of neuronal voltage-gated potassium channels
Cerda, O., & Trimmer, J. S. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.06.064 · Cited by 44 · see citing works
Heldsinger, A. A., Grabauskas, G., Song, I., & Owyang, C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.198945 · Cited by 44 · see citing works
Hermanstyne, T. O., Kihira, Y., Misonou, H., Deitchler, A., Yanagawa, Y., & Misonou, H. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22457 · Cited by 41 · see citing works
Yang, M., Wang, F., Wang, J., Wu, W., Hu, Z., Jin, C. S., Yu, D., Long, L., Fu, H. Q., Xie, N., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00155.2009 · Cited by 39 · see citing works
Shiau, Y., Huang, P., Liou, H., et al. (2003) · Chemical Research in Toxicology · doi:10.1021/tx0341097 · Cited by 36 · see citing works
CDRK and DRK1 K+ channels have contrasting localizations in sensory systems
Hwang, P. M., Cunningham, A. M., Peng, Y., et al. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90427-h · Cited by 36 · see citing works
Tiran, Z., Peretz, A. S., Sines, T., Shinder, V., Sap, J., Attali, B., & Elson, A. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-02-0151 · Cited by 30 · see citing works
Dynamic Modulation of the Kv2.1 Channel by Src-Dependent Tyrosine Phosphorylation
Song, M., Hong, C., Bae, S. H., So, I., & Park, K. (2011) · Journal of Proteome Research · doi:10.1021/pr200770v · Cited by 25 · see citing works
Baver, S. B., & O’Connell, K. M. S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.054 · Cited by 19 · see citing works
Self-citationVERDON, R. (1876) · Nature · doi:10.1038/014351d0 · Cited by 3 · see citing works
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- Authors
- Baver, S. B., Hope, K., Guyot, S., Bjørbaek, C., Kaczorowski, C., & O'Connell, K. M. S.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University of Tennessee Health Science Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-04-16
- Volume
- 34
- Issue
- 16
- Pages
- 5486-5496
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4298648
- OpenAlex
- W2066665477
- Cited by
- 203
- References
- 60
- Citations by year
- 2026: 8 · 2025: 24 · 2024: 30 · 2023: 19 · 2022: 23 · 2021: 20 · 2020: 17 · 2019: 14 · 2018: 20 · 2017: 9 · 2016: 6 · 2015: 10 · 2014: 3
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R00AG039511)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK102918)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, agouti-related protein, neuropeptide Y, arcuate nucleus, hypothalamus, neuronal excitability, Kv2.1 potassium channel, diet-induced obesity, leptin resistance, 4-aminopyridine, resting membrane potential, food intake regulation
- MeSH terms
- Action Potentials, Animals, Arcuate Nucleus of Hypothalamus, Female, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neurons, Neuropeptide Y, Obesity, Leptin, Potassium Channel Blockers, Green Fluorescent Proteins, Mice, Shab Potassium Channels, Agouti-Related Protein, HEK293 Cells, In Vitro Techniques
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