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Cited by 450

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Pyramidal Cell-Interneuron Interactions Underlie Hippocampal Ripple Oscillations

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Stark, Eran, Roux, Lisa, Eichler, Ronny, Senzai, Yuta, Royer, Sebastien, Buzsáki, György·2014·Neuron
DOI 10.1016/j.neuron.2014.06.023
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Abstract

SUMMARY High-frequency ripple oscillations, observed most prominently in the hippocampal CA1 pyramidal layer, are associated with memory consolidation. The cellular and network mechanisms underlying the generation, frequency control, and spatial coherence of the rhythm are poorly understood. Using multisite optogenetic manipulations in freely behaving rodents, we found that depolarization of a small group of nearby pyramidal cells was sufficient to induce high-frequency oscillations, whereas closed-loop silencing of pyramidal cells or activation of parvalbumin-(PV) or somatostatin-immunoreactive interneurons aborted spontaneously occurring ripples. Focal pharmacological blockade of GABAA receptors abolished ripples. Localized PV inter-neuron activation paced ensemble spiking, and simultaneous induction of high-frequency oscillations at multiple locations resulted in a temporally coherent pattern mediated by phase-locked inter-neuron spiking. These results constrain competing models of ripple generation and indicate that temporally precise local interactions between excitatory and inhibitory neurons support ripple generation in the intact hippocampus.

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Metadata

Authors
Stark, E., Roux, L., Eichler, R., Senzai, Y., Royer, S., & Buzsáki, G.
Venue
Neuron
Publisher
Elsevier BV
Published
2014-07
Volume
83
Issue
2
Pages
467-480
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2014.06.023
OpenAlex
W2046999866
Cited by
450
References
15
FWCI
16.51
Type
journal article
Language
en
Open access
bronze
Licence

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CoChat. (2026). Citation check: Pyramidal Cell-Interneuron Interactions Underlie Hippocampal Ripple Oscillations. https://app.cochat.ai/papers/10.1016/j.neuron.2014.06.023
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Stark, E., Roux, L., Eichler, R., Senzai, Y., Royer, S., & Buzsáki, G. (2014). Pyramidal Cell-Interneuron Interactions Underlie Hippocampal Ripple Oscillations. Neuron. https://doi.org/10.1016/j.neuron.2014.06.023

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