Long-duration hippocampal sharp wave ripples improve memory
Open accessAbstract
Longer ripples make better memories: Sharp wave ripples in the hippocampus are thought to play a role in memory formation and action planning. Fernández-Ruiz et al. used multisite electrophysiological recordings combined with optogenetic activation of hippocampal pyramidal neurons in rats performing learning tasks. Learning and correct recall in spatial memory tasks were associated with extended sharp wave ripples. Artificially prolonging these ripples improved working memory performance, whereas aborting the late part of ripples decreased performance. Science , this issue p. 1082
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Memory performance was impaired after blocking hippocampal ripples and enhanced when spontaneously occurring ripples were prolonged by closed-loop optogenetic stimulation.
“Memory performance was impaired after blocking hippocampal ripples 84,132 and enhanced when spontaneously occurring ripples were prolonged by closed-loop optogenetic stimulation.193”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [193]
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Self-citation
- Authors
- Fernández-Ruiz, A., Oliva, A., Fermino de Oliveira, E., Rocha-Almeida, F., Tingley, D., & Buzsáki, G.
- Affiliations
- New York University Neuroscience Institute, New York University, New York, NY 10016, USA.
- Mortimer B. Zuckerman Mind Brain Behavior Institute (US)
- New York University (US)
- Corresponding author
- Oliva, Azahara
- Buzsáki, György
- ORCID
- Venue
- Science
- Published
- 2019-06-14
- Volume
- 364
- Issue
- 6445
- Pages
- 1082-1086
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6693581
- OpenAlex
- W2949722813
- Semantic Scholar
- e45e606e7814b66798fdd18352ee2dc5acec89f2
- Cited by
- 490
- References
- 39
- Citations by year
- 2026: 68 · 2025: 86 · 2024: 75 · 2023: 85 · 2022: 64 · 2021: 54 · 2020: 40 · 2019: 18
- FWCI
- 25.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (1707316)
- National Institutes of Health (MH107396, NS074015, U19NS104590)
- FAPESP (2017/03729-2)
- EMBO Postdoctoral Fellowship (ALTF 120-2017)
- Sir Henry Wellcome Postdoctoral Fellowship
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- hippocampal ripples, memory consolidation, optogenetic stimulation, maze learning, spatial memory, route planning
- MeSH terms
- Memory Consolidation, Animals, Male, Neurons, Maze Learning, Rats, Long-Evans, Rats, CA1 Region, Hippocampal, Optogenetics
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