Cited by 176Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsVisual perception and processing mechanisms

Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons

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Mardinly, A. R., Spiegel, I., Patrizi, A., Centofante, E., Bazinet, J. E., Tzeng, C. P., Mandel-Brehm, C., Harmin, D. A. +3 more·2016·Nature

Abstract

Inhibitory neurons regulate the adaptation of neural circuits to sensory experience, but the molecular mechanisms by which experience controls the connectivity between different types of inhibitory neuron to regulate cortical plasticity are largely unknown. Here we show that exposure of dark-housed mice to light induces a gene program in cortical vasoactive intestinal peptide (VIP)-expressing neurons that is markedly distinct from that induced in excitatory neurons and other subtypes of inhibitory neuron. We identify Igf1 as one of several activity-regulated genes that are specific to VIP neurons, and demonstrate that IGF1 functions cell-autonomously in VIP neurons to increase inhibitory synaptic input onto these neurons. Our findings further suggest that in cortical VIP neurons, experience-dependent gene transcription regulates visual acuity by activating the expression of IGF1, thus promoting the inhibition of disinhibitory neurons and affecting inhibition onto cortical pyramidal neurons.

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  • Neuronal activity induces a different transcriptional response in VIP+ interneurons, promoting inhibitory synapse formation on these cells.

    “In contrast, neuronal activity induces a completely different transcriptional response in VIP+ interneurons, promoting the formation of inhibitory synapses on these cells (Mardinly et al., 2016).”

    From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Mardinly et al., 2016

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Authors
Mardinly, A. R., Spiegel, I., Patrizi, A., Centofante, E., Bazinet, J. E., Tzeng, C. P., Mandel-Brehm, C., Harmin, D. A., Adesnik, H., Fagiolini, M., & Greenberg, M. E.
Affiliations
  • University of California, Berkeley (US)
  • Harvard University (US)
  • Boston Children's Hospital (US)
Corresponding author
Greenberg, M. E.
Venue
Nature
Published
2016-03
Volume
531
Issue
7594
Pages
371-375
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2293311540
Cited by
176
References
37
Citations by year
2026: 6 · 2025: 22 · 2024: 12 · 2023: 14 · 2022: 18 · 2021: 17 · 2020: 13 · 2019: 23 · 2018: 19 · 2017: 20 · 2016: 12
FWCI
13.83
Type
journal article
Language
en
Open access
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • RePEc: Research Papers in Economics (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (P01NS047572, R01NS028829, R37NS028829)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD018655)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
insulin-like growth factor I, cortical inhibition, visual cortex, visual acuity, excitation-inhibition balance, light exposure, activity-dependent gene expression, inhibitory synaptic input, cortical plasticity, pyramidal neurons
MeSH terms
Animals, Female, Insulin-Like Growth Factor I, Male, Mice, Inbred C57BL, Neural Inhibition, Neural Pathways, Neuronal Plasticity, Neurons, Synapses, Vasoactive Intestinal Peptide, Vision, Ocular, Visual Cortex, Pyramidal Cells, Mice

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