Response Selectivity Is Correlated to Dendritic Structure in Parvalbumin-Expressing Inhibitory Neurons in Visual Cortex
Open accessAbstract
Inhibitory neurons have been shown to perform a variety of functions within brain circuits, including shaping response functions in target cells. Still, how the properties of specific inhibitory neuron classes relate to their local circuits remains unclear. To better understand the distribution and origins of orientation selectivity in inhibitory neurons expressing the calcium binding protein parvalbumin (PV) in the mouse primary visual cortex, we labeled PV(+) neurons with red fluorescent protein (RFP) and targeted them for cell-attached electrophysiological recordings. PV(+) neurons could be broadly tuned or sharply tuned for orientation but tended to be more broadly tuned than unlabeled neurons on average. The dendritic morphology of PV(+) cells, revealed by intracellular labeling, was strongly correlated with tuning: highly tuned PV(+) neurons had shorter dendrites that branched nearer to the soma and had smaller dendritic fields overall, whereas broadly tuned PV(+) neurons had longer dendrites that branched farther from the soma, producing larger dendritic fields. High-speed two-photon calcium imaging of visual responses showed that the orientation preferences of highly tuned PV(+) neurons resembled the preferred orientations of neighboring cells. These results suggest that the diversity of the local neighborhood and the nature of dendritic sampling may both contribute to the response selectivity of PV(+) neurons.
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The complexity and extent of the dendritic arbor of supragranular PV interneurons in visual cortex correlate with their selectivity to visual stimuli.
“the complexity and extent of the dendritic arbor of supragranular PV INs in visual cortex correlate with their selectivity to visual stimuli”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Runyan and Sur, 2013
The Results section, “Morphology of PV+ neurons: dendritic extent, but not complexity, correlates with orientation selectivity” (page not provided), reports that measures of dendritic extent correlated with orientation selectivity. It explicitly reports that neither measure of dendritic complexity correlated significantly, so the claim's complexity component is not supported. (LLM, conf=0.92)
Experimental — accuracy not yet measuredFeature selectivity may simply reflect the availability of inputs within a cell's dendritic domain.
“Therefore, feature selectivity would simply be a reflection of input availability within a cell’s dendritic domain (Runyan and Sur, 2013).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Runyan and Sur, 2013
The Introduction (page unavailable) suggests that dendritic arbors may influence orientation selectivity in PV-positive visual-cortex neurons by limiting the number and diversity of local inputs. The Discussion (page unavailable) likewise says local input sampling could produce high selectivity. This supports the proposed mechanism, but not the citing sentence’s stronger assertion that feature selectivity generally would simply reflect input availability. (LLM, conf=0.84)
Experimental — accuracy not yet measuredOrientation selectivity of PV neurons is inversely correlated with the extent of their dendritic arbor, suggesting that PV interneuron tuning may relate to the spatial extent over which they sample excitatory inputs.
“the orientation selectivity of PV neurons was later shown to be inversely correlated with the extent of their dendritic arbor, suggesting that tuning of PV INs could be simply related to the spatial extent to which they can sample excitatory inputs (Runyan and Sur, 2013).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Runyan and Sur, 2013
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- Authors
- Runyan, C. A., & Sur, M.
- Affiliations
- Massachusetts Institute of Technology (US)
- ORCID
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-07-10
- Volume
- 33
- Issue
- 28
- Pages
- 11724-11733
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3724550
- OpenAlex
- W2061469173
- Cited by
- 67
- References
- 54
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 2 · 2018: 9 · 2017: 4 · 2016: 9 · 2015: 3 · 2014: 6 · 2013: 2
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion)
- Funders
- Simons Foundation
- National Institutes of Health (EY007023)
- National Eye Institute (F32EY007023, EY018041, EY007023, R01EY007023)
- National Institute of Neurological Disorders and Stroke (NS679512)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- parvalbumin, inhibitory interneurons, orientation selectivity, dendritic morphology, primary visual cortex, orientation tuning, two-photon calcium imaging, mouse visual cortex
- MeSH terms
- Animals, Dendrites, Female, Gene Expression Regulation, Male, Mice, Inbred C57BL, Neural Inhibition, Neurons, Parvalbumins, Photic Stimulation, Visual Cortex, Mice
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