The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Intrinsic Control of Axon Regeneration
Open accessAbstract
A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which dictates a battery of injury responses in axons and cell bodies. While some of these regulatory mechanisms are evolutionarily conserved, others are unique to the mammalian central nervous system (CNS) where spontaneous regeneration usually does not occur. Here we examine our current understanding of these mechanisms at cellular and molecular terms and discuss their potential implications for promoting axon regeneration and functional recovery after nerve injury.
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Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686
Self-citationSustained axon regeneration induced by co-deletion of PTEN and SOCS3
Sun, F., Park, K. K., Belin, S., Wang, D., Lu, T., Chen, G., Zhang, K., Yeung, C., Feng, G., Yankner, B. A., et al. (2011) · Nature · doi:10.1038/nature10594 · Cited by 754
Self-citationFunctional regeneration after laser axotomy
Yanik, M. F., Cinar, H., Cinar, H. N., Chisholm, A. D., Jin, Y., & Ben-Yakar, A. (2004) · Nature · doi:10.1038/432822a · Cited by 598
Self-citationThe Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons
Holt, C. E., & Schuman, E. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.036 · Cited by 525
Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury
Lang, B. T., Cregg, J. M., DePaul, M. A., Tran, A. P., Xu, K., Dyck, S. M., Madalena, K. M., Brown, B. P., Weng, Y.-L., Li, S., et al. (2015) · Nature · doi:10.1038/nature13974 · Cited by 465
IGF-I specifically enhances axon outgrowth of corticospinal motor neurons
Özdinler, P. H., & Macklis, J. D. (2006) · Nature Neuroscience · doi:10.1038/nn1789 · Cited by 341
Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
Wahl, A. S., Omlor, W., Rubio, J. C., Chen, J. L., Zheng, H., Schröter, A., Gullo, M., Weinmann, O., Kobayashi, K., Helmchen, F., et al. (2014) · Science · doi:10.1126/science.1253050 · Cited by 322
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
Huntwork-Rodriguez, S., Wang, B., Watkins, T., Ghosh, A. S., Pozniak, C. D., Bustos, D., Newton, K., Kirkpatrick, D. S., & Lewcock, J. W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201303066 · Cited by 154
Dupraz, S., Grassi, D., Bernis, M. E., Sosa, L., Bisbal, M., Gastaldi, L., Jausoro, I., Cáceres, A., Pfenninger, K. H., & Quiroga, S. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3907-09.2009 · Cited by 111
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Poplawski, G. H. D., Kawaguchi, R., Van Niekerk, E., Lu, P., Mehta, N., Canete, P., Lie, R., Dragatsis, I., Meves, J. M., Zheng, B., et al. (2020) · Nature · doi:10.1038/s41586-020-2200-5 · Cited by 247
Agostinone, J., Alarcon-Martinez, L., Gamlin, C., Yu, W.-Q., Wong, R. O. L., & Di Polo, A. (2018) · Brain · doi:10.1093/brain/awy142 · Cited by 124
An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury
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Chen, Z., Sun, Z., Fan, Y., Yin, M., Jin, C., Guo, B., Yin, Y., Quan, R., Zhao, S., Han, S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c09892 · Cited by 48
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Metadata
- Authors
- He, Z., & Jin, Y.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 90
- Issue
- 3
- Pages
- 437-451
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2140573520
- Cited by
- 646
- References
- 9
- FWCI
- 25.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
