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Transsynaptic Mapping of Second-Order Taste Neurons in Flies by trans-Tango
Open accessAbstract
Mapping neural circuits across defined synapses is essential for understanding brain function. Here we describe trans-Tango, a technique for anterograde transsynaptic circuit tracing and manipulation. At the core of trans-Tango is a synthetic signaling pathway that is introduced into all neurons in the animal. This pathway converts receptor activation at the cell surface into reporter expression through site-specific proteolysis. Specific labeling is achieved by presenting a tethered ligand at the synapses of genetically defined neurons, thereby activating the pathway in their postsynaptic partners and providing genetic access to these neurons. We first validated trans-Tango in the Drosophila olfactory system and then implemented it in the gustatory system, where projections beyond the first-order receptor neurons are not fully characterized. We identified putative second-order neurons within the sweet circuit that include projection neurons targeting known neuromodulation centers in the brain. These experiments establish trans-Tango as a flexible platform for transsynaptic circuit analysis.
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From A connectome and analysis of the adult Drosophila central brain (2020) · cites this paper as Talay et al., 2017
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Metadata
- Authors
- Talay, M., Richman, E. B., Snell, N. J., Hartmann, G. G., Fisher, J. D., Sorkaç, A., Santoyo, J. F., Chou-Freed, C., Nair, N., Johnson, M., Szymanski, J. R., & Barnea, G.
- Affiliations
- Brown University (US)
- Corresponding author
- Barnea, Gilad
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 96
- Issue
- 4
- Pages
- 783-795.e4
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5693608
- OpenAlex
- W2765562046
- Cited by
- 301
- References
- 82
- Citations by year
- 2026: 26 · 2025: 31 · 2024: 53 · 2023: 39 · 2022: 35 · 2021: 40 · 2020: 38 · 2019: 18 · 2018: 20 · 2017: 1
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R21DCO14333, R01MH086920, R01MH105368, R01DC013561)
- Brown University: BIBS Innovation Award
- OVPR Salomon and Seed Awards
- Pew Charitable Trus
- Suna & İnan Kıraç Foundation
- BIBS
- Karen T. Romer UTRA (DGE1058262)
- National Science Foundation Graduate Research Fellowship Program
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- gustatory system, Drosophila, site-specific proteolysis, tethered ligand, projection neurons, neuromodulation, olfactory system, neural circuit mapping
- MeSH terms
- Animals, Drosophila, Neural Pathways, Neurons, Olfactory Pathways, Animals, Genetically Modified, Taste Perception, Neuroanatomical Tract-Tracing Techniques
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