Muscarinic M1 Receptor Overstimulation Disrupts Working Memory Activity for Rules in Primate Prefrontal Cortex

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Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease

Sun, Q., Zhang, J., Li, A., Yao, M., Liu, G., Chen, S., Luo, Y., Wang, Z., Gong, H., Li, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28493-4 · Cited by 85 · see citing works

Antiallergic drug desloratadine as a selective antagonist of 5HT 2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction

Lu, J., Zhang, C., Lv, J., Zhu, X., Jiang, X., Lü, W., Lu, Y., Tang, Z., Wang, J., & Shen, X. (2020) · Aging Cell · doi:10.1111/acel.13286 · Cited by 83 · see citing works

Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing

Orlando, I. F., Shine, J. M., Robbins, T. W., Rowe, J. B., & O’Callaghan, C. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105167 · Cited by 77 · see citing works

Prefrontal circuit organization for executive control

Kamigaki, T. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.08.017 · Cited by 65 · see citing works

Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder

Lobentanzer, S., Hanin, G., Klein, J., & Soreq, H. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.017 · Cited by 50 · see citing works

Prefrontal cortex and cognitive aging in macaque monkeys

Upright, N. A., & Baxter, M. G. (2021) · American Journal of Primatology · doi:10.1002/ajp.23250 · Cited by 44 · see citing works

Cell class-specific modulation of attentional signals by acetylcholine in macaque frontal eye field

Dasilva, M., Brandt, C., Gotthardt, S., Gieselmann, M. A., Distler, C., & Thiele, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905413116 · Cited by 38 · see citing works

A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia

Dean, B., Bakker, G., Ueda, H. R., Tobin, A. B., Brown, A., & Kanaan, R. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1124333 · Cited by 38 · see citing works

A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe /PSEN1ΔE9 mice

Abd‐Elrahman, K. S., Sarasija, S., Colson, T. L., & Ferguson, S. S. G. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15750 · Cited by 33 · see citing works

The potential of muscarinic M1 and M4 receptor activators for the treatment of cognitive impairment associated with schizophrenia

Yohn, S. E., Harvey, P. D., Brannan, S. K., & Horan, W. P. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1421554 · Cited by 33 · see citing works

Rescuing the attentional performance of rats with cholinergic losses by the M1 positive allosteric modulator TAK-071

Kucinski, A. J., Phillips, K. B., Cherian, A. K., & Sarter, M. F. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05354-5 · Cited by 29 · see citing works

M 1 -selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates

Hassani, S. A., Neumann, A. R., Russell, J. K., Jones, C. K., & Womelsdorf, T. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2216792120 · Cited by 21 · see citing works

Nucleus basalis stimulation enhances working memory by stabilizing stimulus representations in primate prefrontal cortical activity

Qi, X.-L., Liu, R., Singh, B., Bestue, D., Compte, A., Vazdarjanova, A. I., Blake, D. T., & Constantinidis, C. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109469 · Cited by 24 · see citing works

Effects of muscarinic M1 receptor stimulation on reinforcing and neurochemical effects of cocaine in rats

Weikop, P., Jensen, K. L., & Thomsen, M. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0684-1 · Cited by 19 · see citing works

Cholinergic models of memory impairment in animals and man: scopolamine vs. biperiden

Blokland, A. (2022) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000670 · Cited by 18 · see citing works

Acetylcholine Receptor Stimulation for Cognitive Enhancement: Better the Devil You Know?

Baxter, M. G., & Crimins, J. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.018 · Cited by 17 · see citing works

Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys

Hassani, S. A., Lendor, S., Neumann, A. R., Roy, K. S., Boroujeni, K. B., Hoffman, K. L., Pawliszyn, J. B., & Womelsdorf, T. (2021) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.11.012 · Cited by 17 · see citing works

First‐in‐man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1‐receptor partial agonist for the treatment of dementias

Bakker, C., Tasker, T. C. G., Liptrot, J., Hart, E. P., Klaassen, E. S., Prins, S., van der Doef, T. F., Brown, G. A., Brown, A., Congreve, M., et al. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14710 · Cited by 16 · see citing works

Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors

Vijayraghavan, S., & Everling, S. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.648624 · Cited by 15 · see citing works

Involvement of Nicotinic Receptors in Working Memory Function

Galvin, V. C., Arnsten, A. F. T., & Wang, M. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_142 · Cited by 15 · see citing works

Curcumin Suppresses Lead-Induced Inflammation and Memory Loss in Mouse Model and In Silico Molecular Docking

Changlek, S., Rana, M. N., Phyu, M. P., Karim, N., Majima, H. J., & Tangpong, J. (2022) · Foods · doi:10.3390/foods11060856 · Cited by 16 · see citing works

Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey

Tsolias, A., & Medalla, M. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.795325 · Cited by 13 · see citing works

M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance

Galvin, V. C., Yang, S., Lowet, A. S., Datta, D., Duque, A., Arnsten, A. F. T., & Wang, M. (2021) · Current Research in Neurobiology · doi:10.1016/j.crneur.2021.100016 · Cited by 13 · see citing works

Biperiden Selectively Impairs Verbal Episodic Memory in a Dose- and Time-Dependent Manner in Healthy Subjects

Borghans, L. G. J. M., Sambeth, A., & Blokland, A. (2019) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001157 · Cited by 10 · see citing works

Cholinergic Neuromodulation of Prefrontal Attractor Dynamics Controls Performance in Spatial Working Memory

Mahrach, A., Bestue, D., Qi, X.-L., Constantinidis, C., & Compte, A. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1225-23.2024 · Cited by 7 · see citing works

Relationship between plasma clozapine/N-desmethylclozapine and changes in basal forebrain-dorsolateral prefrontal cortex coupling in treatment-resistant schizophrenia

Sarpal, D. K., Blazer, A., Wilson, J. D., Calabro, F. J., Foran, W., Kahn, C. E., Luna, B., & Chengappa, K. N. R. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.03.014 · Cited by 9 · see citing works

Focal acetylcholinergic modulation of the human midcingulo‐insular network during attention: Meta‐analytic neuroimaging and behavioral evidence

Chakraborty, S., Lee, S. K., Arnold, S. M., Haast, R. A. M., KHAN, A. R., & Schmitz, T. W. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15990 · Cited by 8 · see citing works

Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression

Šanda, P., Hlinka, J., van den Berg, M., Škoch, A., Bazhenov, M., Keliris, G. A., & Krishnan, G. P. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012099 · Cited by 9 · see citing works

M1 receptor positive allosteric modulators discovery approaches

Mandai, T., Simen, A. A., Laurenza, A., & Kimura, H. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2025.03.001 · Cited by 4 · see citing works

Spike afterhyperpolarizations govern persistent firing dynamics in rat neocortical and hippocampal pyramidal cells

Cui, E., Estright, A. W., Pressler, R. T., & Strowbridge, B. W. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0570-22.2022 · Cited by 4 · see citing works

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Lee, R., Kim, G., Black, E. R., & Kim, S. (2026) · Advanced Science · doi:10.1002/advs.77858 · Cited by 4 · see citing works

Nucleus Basalis Stimulation Enhances Working Memory by Stabilizing Attractor Networks in Prefrontal CortexPreprint

Qi, X.-L., Liu, R., Singh, B., Bestue, D., Compte, A., Vazdarjanova, A. I., Blake, D. T., & Constantinidis, C. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/674465 · Cited by 4 · see citing works

Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior

Boroujeni, K. B., Balaram, P., Tiesinga, P. H. E., & Womelsdorf, T. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102873 · Cited by 4 · see citing works

Caveolae with serotonin and NMDA receptors as promising targets for the treatment of Alzheimer’s disease

Nakashima, M. (2024) · International Journal of Physiology Pathophysiology and Pharmacology · doi:10.62347/mtwv3745 · Cited by 3 · see citing works

Hippocampal delta oscillations entrain neuronal activity, modulate gamma amplitude and convey information about running speed on a treadmillPreprint

Furtunato, A. M. B., Pedrosa, R., Soares, B. L., Tort, A. B. L., & Belchior, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.24.477542 · Cited by 3 · see citing works

CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment

Fisher, A., & Levey, A. I. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19088-9.00016-0 · Cited by 4 · see citing works

Concentration-dependent cellular effects of VU0364572 on medium spiny neurons in the nucleus accumbens of male and female mice

Wu, C., Leguizamón, C. R. R., Thomsen, M., & Kohlmeier, K. A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177915 · Cited by 2 · see citing works

Allosteric modulation of M1 or M4 muscarinic receptors restores eNOS expression and L-arginine metabolism in dementia models and synergizes with NO releasers

Płoska, A., Radulska, A., Siekierzycka, A., Cieślik, P., Santocki, M., Dobrucki, I. T., Kalinowski, L., & Wierońska, J. M. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.174085 · Cited by 2 · see citing works

Improving Visual Working Memory with Cholinergic Deep Brain Stimulation

Bava, J., Wang, Z., Bick, S. K. B., Englot, D. J., & Constantinidis, C. (2023) · Brain Sciences · doi:10.3390/brainsci13060917 · Cited by 2 · see citing works

The antioxidative effect of esculin on lead acetate-induced neurotoxicity in the hippocampus and cortex of C57BL/6 mice

Sumathi, T., Murugan, A., Rajavel, S., & IPerumal, S. S. (2023) · International Journal of Pharmaceutical Sciences and Drug Research · doi:10.25004/ijpsdr.2023.150401 · Cited by 2 · see citing works

Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices

Tsolias, A., Mojica, C. A., Yamani, R., Khanna, S., Abdullatif, S. A., Snyder, B. J., Chang, W., Guillamón-Vivancos, T., Goodliffe, J. W., Capriglione, A. L., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-09866-7 · Cited by 1 · see citing works

Distinctive Molecular Mechanisms in Higher Cortical Circuits Confer Vulnerability to Mental Disorders

Wang, M., Galvin, V. C., Joyce, M. K. P., Datta, D., Yang, S., Disney, A. A., & Arnsten, A. F. T. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.06.008 · Cited by 1 · see citing works

Nicotine causes highly localized and tuned changes in thalamocortical gain that cascade strongly and selectively through the cortical circuitPreprint

Galvin, V. C., & Disney, A. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.22.707315

Multiplexed changes in synaptic transmission underlie stress-induced reduction of persistent firing in the parietal cortex

Proddutur, A., Rindner, D. J., Azouz, G., Beier, K. T., & Lür, G. (2026) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2026.102895

Nauclea officinalis extract rescues working memory deficits in adolescent maternal immune activation offspring by restoring cholinergic signaling

An, L., Li, Z., Wang, Y., Feng, L., & Sun, W. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1918425

Muscarinic Attenuation of Mnemonic Rule Representation in Macaque Dorsolateral Prefrontal Cortex during a Pro- and Anti-Saccade Task

Major, A. J., Vijayraghavan, S., & Everling, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2454-15.2015 · Cited by 32 · see citing works

Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors

Vijayraghavan, S., & Everling, S. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.648624 · Cited by 15 · see citing works

Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex

Galvin, V. C., Yang, S. T., Paspalas, C. D., Yang, Y., Jin, L. E., Datta, D., Morozov, Y. M., Lightbourne, T. C., Lowet, A. S., Rakic, P., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.02.030 · Cited by 79 · see citing works

Muscarinic M1 Receptors Modulate Working Memory Performance and Activity Via KCNQ Potassium Channels in Primate Prefrontal CortexPreprint

Galvin, V. C., Yang, S., Paspalas, C. D., Yang, Y., Jin, L. E., Datta, D., Morozov, Y. M., Lightbourne, T. C., Lowet, A. S., RAKIC, P. T., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3492110 · Cited by 5 · see citing works

Cholinergic Overstimulation Attenuates Rule Selectivity in Macaque Prefrontal Cortex

Major, A. J., Vijayraghavan, S., & Everling, S. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3198-17.2017 · Cited by 22 · see citing works