Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals
Open accessAbstract
Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice.
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bHR rats that underwent Pavlovian training in the presence of a dopamine receptor antagonist did not acquire a sign-tracking CR, consistent with previous reports; however, dopamine antagonism had no effect on learning a goal-tracking CR in bLR rats.
“Third, bHR rats that underwent Pavlovian training in the presence of a dopamine receptor antagonist did not acquire a sign-tracking CR, consistent with previous reports24; however, dopamine antagonism had no effect on learning a goal-tracking CR in bLR rats.”
From A selective role for dopamine in stimulus-reward learning (2011) · cites this paper as [24]
The attribution of incentive salience is the product of previous experience (i.e., learned associations) interacting with an individual's genetic propensity and neurobiological state.
“The attribution of incentive salience is the product of previous experience (i.e., learned associations) interacting with an individual’s genetic propensity and neurobiological state 16,24–27.”
From A selective role for dopamine in stimulus-reward learning (2011) · cites this paper as [24]
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- Authors
- Clark, J. J., Sandberg, S. G., Wanat, M. J., Gan, J. O., Horne, E. A., Hart, A. S., Akers, C. A., Parker, J. G., Willuhn, I., Martinez, V., Evans, S. B., Stella, N., & Phillips, P. E. M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Phillips, Paul E M
- ORCID
- Venue
- Nature Methods
- Published
- 2009-12-27
- Volume
- 7
- Issue
- 2
- Pages
- 126-129
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- PMC
- PMC2849934
- OpenAlex
- W2014971298
- Cited by
- 378
- References
- 23
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 22 · 2023: 17 · 2022: 21 · 2021: 27 · 2020: 33 · 2019: 23 · 2018: 39 · 2017: 30 · 2016: 28 · 2015: 21 · 2014: 24 · 2013: 19 · 2012: 15
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Methods (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- Funders
- National Institutes of Health (2t32da007278-31)
- National Institute on Alcohol Abuse and Alcoholism (T32AA007455)
- National Institute of Mental Health (R01MH079292)
- National Institute on Drug Abuse (T32-DA007278, F32DA024540, R01DA014486, R21DA021793, R21DA024140)
- National Institute of General Medical Sciences (T32GM007270)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Keywords
- dopamine detection, electrochemical microsensors, chronic implantation, dopaminergic neurons, biocompatible sensors, rats, mice
- MeSH terms
- Animals, Behavior, Animal, Dopamine, Electrochemistry, Electrodes, Implanted, Equipment Design, Mesencephalon, Microelectrodes, Miniaturization, Sensitivity and Specificity, Reproducibility of Results, Biosensing Techniques, Neurotransmitter Agents, Monitoring, Ambulatory, Equipment Failure Analysis, Mice, Rats
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