A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code

Yuan, Zhengwei; Qi, Zhongyang; Wang, Ruiyu; Cui, Yuting; An, Sile; Wu, Guoli; Feng, Qiru; Lin, Rui; Dai, Ruicheng; Li, Anan; Gong, Hui; Luo, Qingming; Fu, Ling; Luo, Minmin

doi:10.1016/j.neuron.2023.08.022

Cited by 45Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code

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Yuan, Zhengwei, Qi, Zhongyang, Wang, Ruiyu, Cui, Yuting, An, Sile, Wu, Guoli, Feng, Qiru, Lin, Rui +6 more·2023·Neuron

DOI 10.1016/j.neuron.2023.08.022

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Abstract

Reward devaluation adaptively controls reward intake. It remains unclear how cortical circuits causally encode reward devaluation in healthy and depressed states. Here, we show that the neural pathway from the anterior cingulate cortex (ACC) to the basolateral amygdala (BLA) employs a dynamic inhibition code to control reward devaluation and depression. Fiber photometry and imaging of ACC pyramidal neurons reveal reward-induced inhibition, which weakens during satiation and becomes further attenuated in depression mouse models. Ablating or inhibiting these neurons desensitizes reward devaluation, causes reward intake increase and ultimate obesity, and ameliorates depression, whereas activating the cells sensitizes reward devaluation, suppresses reward consumption, and produces depression-like behaviors. Among various ACC neuron subpopulations, the BLA-projecting subset bidirectionally regulates reward devaluation and depression-like behaviors. Our study thus uncovers a corticoamygdalar circuit that encodes reward devaluation via blunted inhibition and suggests that enhancing inhibition within this circuit may offer a therapeutic approach for treating depression.

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ACC is required for monitoring and prediction of an action-outcome relationship by representing reward-related information such as reward value and cost of action.
“The ACC is required for monitoring and prediction of an action-outcome relationship30,31, by representing various reward-related information, such as reward value and cost of action32–34.”
From Dissociable roles of prefrontal plasticity in decision-making strategy and execution of habitual behavior (2026) · cites this paper as [30]

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Authors: Yuan, Z., Qi, Z., Wang, R., Cui, Y., An, S., Wu, G., Feng, Q., Lin, R., Dai, R., Li, A., Gong, H., Luo, Q., Fu, L., & Luo, M.
Affiliations: Peking University (CN)
National Institute of Biological Sciences, Beijing (CN)
Wuhan National Laboratory for Optoelectronics (CN)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Luo, Minmin
ORCID: Yuan, Zhengwei
Wang, Ruiyu
Cui, Yuting
An, Sile
Lin, Rui
Li, Anan
Gong, Hui
Luo, Qingming
Fu, Ling
Luo, Minmin
Venue: Neuron
Publisher: Elsevier BV
Published: 2023-12
Volume: 111
Issue: 23
Pages: 3837-3853.e5
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2023.08.022
OpenAlex: W4386887293
Cited by: 45
References: 96
Citations by year: 2026: 16 · 2025: 22 · 2024: 5 · 2023: 2
FWCI: 5.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: reward devaluation, depression, anterior cingulate cortex, basolateral amygdala, obesity, depression-like behavior, pyramidal neurons, depression treatment
MeSH terms: Animals, Conditioning, Operant, Depression, Reward, Satiation, Mice, Basolateral Nuclear Complex

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A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code

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