Investigations into the involvement of NMDA mechanisms in recognition memory
Open accessAbstract
This review will focus on evidence showing that NMDA receptor neurotransmission is critical for synaptic plasticity processes within brain regions known to be necessary for the formation of object recognition memories. The aim will be to provide evidence concerning NMDA mechanisms related to recognition memory processes and show that recognition memory for objects, places or associations between objects and places depends on NMDA neurotransmission within the perirhinal cortex, temporal association cortex medial prefrontal cortex and hippocampus. Administration of the NMDA antagonist AP5, selectively into each of these brain regions has revealed that the extent of the involvement NMDA receptors appears dependent on the type of information required to solve the recognition memory task; thus NMDA receptors in the perirhinal cortex are crucial for the encoding of long-term recognition memory for objects, and object-in-place associations, but not for short-term recognition memory or for retrieval. In contrast the hippocampus and medial prefrontal cortex are required for both long-term and short-term recognition memory for places or associations between objects and places, or for recognition memory tasks that have a temporal component. Such studies have therefore confirmed that the multiple brain regions make distinct contributions to recognition memory but in addition that more than one synaptic plasticity process must be involved. This article is part of the Special Issue entitled 'Glutamate Receptor-Dependent Synaptic Plasticity'.
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In the OiP test, rodents explore the two displaced objects more than the two stationary ones, evidencing memory for previous places of objects (object-location associations).
“Rodents explored the two displaced objects more than the two that were stationary. This preference evidences that the animals have memory for the previous places of the objects, i.e., established an association between specific objects and specific locations (for review see (Warburton et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Warburton et al., 2013
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- Authors
- Warburton, E. C., Barker, G. R. I., & Brown, M. W.
- Affiliations
- University of Bristol (GB)
- Corresponding author
- Warburton, E. Clea
- ORCID
- Warburton, E. Clea
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 74
- Pages
- 41-47
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC3895175
- OpenAlex
- W1983971996
- Cited by
- 98
- References
- 71
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 6 · 2021: 12 · 2020: 7 · 2019: 5 · 2018: 14 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 9 · 2013: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Neuropharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council (BB/E010407/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- NMDA receptor, recognition memory, object recognition memory, perirhinal cortex, hippocampus, medial prefrontal cortex, temporal association cortex, AP5, synaptic plasticity, glutamate receptors, memory encoding, memory retrieval
- MeSH terms
- Animals, Hippocampus, Memory, Microinjections, Synaptic Transmission, Neuronal Plasticity, Temporal Lobe, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Recognition, Psychology
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