Cited by 98Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

Investigations into the involvement of NMDA mechanisms in recognition memory

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Warburton, E. Clea, Barker, Gareth R.I., Brown, Malcom W.·2013·Neuropharmacology

Abstract

This review will focus on evidence showing that NMDA receptor neurotransmission is critical for synaptic plasticity processes within brain regions known to be necessary for the formation of object recognition memories. The aim will be to provide evidence concerning NMDA mechanisms related to recognition memory processes and show that recognition memory for objects, places or associations between objects and places depends on NMDA neurotransmission within the perirhinal cortex, temporal association cortex medial prefrontal cortex and hippocampus. Administration of the NMDA antagonist AP5, selectively into each of these brain regions has revealed that the extent of the involvement NMDA receptors appears dependent on the type of information required to solve the recognition memory task; thus NMDA receptors in the perirhinal cortex are crucial for the encoding of long-term recognition memory for objects, and object-in-place associations, but not for short-term recognition memory or for retrieval. In contrast the hippocampus and medial prefrontal cortex are required for both long-term and short-term recognition memory for places or associations between objects and places, or for recognition memory tasks that have a temporal component. Such studies have therefore confirmed that the multiple brain regions make distinct contributions to recognition memory but in addition that more than one synaptic plasticity process must be involved. This article is part of the Special Issue entitled 'Glutamate Receptor-Dependent Synaptic Plasticity'.

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Authors
Warburton, E. C., Barker, G. R. I., & Brown, M. W.
Affiliations
University of Bristol (GB)
Corresponding author
Warburton, E. Clea
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2013-11
Volume
74
Pages
41-47
ISSN
0028-3908 (ISSN-L)
OpenAlex
W1983971996
Cited by
98
References
71
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 6 · 2021: 12 · 2020: 7 · 2019: 5 · 2018: 14 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 9 · 2013: 1
FWCI
0.80
Type
journal article
Language
en
Open access
Locations
  • Neuropharmacology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust
  • Biotechnology and Biological Sciences Research Council (BB/E010407/1)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
NMDA receptor, recognition memory, object recognition memory, perirhinal cortex, hippocampus, medial prefrontal cortex, temporal association cortex, AP5, synaptic plasticity, glutamate receptors, memory encoding, memory retrieval
MeSH terms
Animals, Hippocampus, Memory, Microinjections, Synaptic Transmission, Neuronal Plasticity, Temporal Lobe, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Recognition, Psychology

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