GluN1 and GluN2A NMDA receptor subunits increase in the hippocampus during memory consolidation in the Rat
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It is widely accepted that NMDA receptors (NMDAR) are required for learning and memory formation, and for synaptic plasticity induction. We have previously shown that hippocampal GluN1 and GluN2A NMDAR subunits significantly increased following habituation of rats to an open field (OF), while GluN2B remained unchanged. Similar results were obtained after CA1-LTP induction in rat hippocampal slices. Other studies have also shown NMDAR up regulation at earlier and later time points after LTP induction or learning acquisition. In this work, we have studied NMDAR subunits levels in the hippocampus and prefrontal cortex (PFC) after OF habituation and after object recognition (OR), to find out whether rising of NMDAR subunits is a general and structure-specific feature during memory formation. In 1, 2 and 3 months old rats there was an increase in hippocampal GluN1 and GluN2A, but not in GluN2B levels 70 minutes after OF habituation. This rise overlaps with early phase of memory consolidation, suggesting a putative relationship between them. The increases fell down to control levels 90 minutes after training. Similar results were obtained in the hippocampus of adult rats 70 minutes after OR training, without changes in PFC. Following OF test or OR discrimination phase, NMDAR subunits remained unchanged. Hence, rising of hippocampal GluN1 and GluN2A appears to be a general feature after novel ‘spatial/ discrimination’ memory acquisition. To start investigating the dynamics and possible mechanisms of these changes, we have studied hippocampal neuron cultures stimulated by KCl to induce plasticity. GluN1 and GluN2A increased both in dendrites and neuronal bodies, reaching a maximum 75 minutes later and returning to control levels at 90 minutes. Translation and/or transcription and mobilization differentially contribute to this rise in subunits in bodies and dendrites. Our results showed that the NMDAR subunits increase follows a similar time course both in vitro and in vivo. These changes happen in the hippocampus where a spatial representation of the environment is being formed making possible STM and LTM; appear to be structure-specific; are preserved along life; and could be related to synaptic tagging and/or to memory consolidation of new spatial/discrimination information.
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These NMDA-R changes suggest roles in novelty discrimination of an environment.
“suggesting their roles in novelty discrimination of an environment”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Cercato et al., 2017
NMDA-R GluN1 and GluN2A levels were elevated in the hippocampus but not in the PFC after habituation to an open field and exploration in the NOP sample trial, while they did not change after the NOP test.
“NMDA-R GluN1 and GluN2A levels were elevated in the hippocampus, but not in the PFC, after habituation to an open field and exploration in the NOP sample trial, while they did not change after the NOP test”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Cercato et al., 2017
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HDAC6 Inhibition Drives Synaptic Protein Acetylation and Enhances Long-Term Memory in Mice
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Behind the scenes: Are latent memories supported by calcium independent plasticity?
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Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish.Preprint
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- Authors
- Cercato, M. C., Vázquez, C. A., Kornisiuk, E., Aguirre, A. I., Colettis, N., Snitcofsky, M., Jerusalinsky, D. A., & Baez, M. V.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Jerusalinsky, Diana A.
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2017-01-13
- Volume
- 10
- Pages
- 242-242
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC5233710
- OpenAlex
- W2576127508
- Cited by
- 55
- References
- 56
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 12 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 1 · 2015: 1
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Greater South Information System
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Universidad de Buenos Aires (CONICET)
- Agencia Nacional de Promoción Científica y Tecnológica (PICT-2013-2221, CONICET)
- Secretaría de Ciencia y Técnica, Universidad de Buenos Aires
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- NMDA receptor subunits, GluN1, GluN2A, GluN2B, memory consolidation, hippocampus, prefrontal cortex, object recognition memory, spatial memory, habituation, long-term potentiation, synaptic plasticity, synaptic tagging, short-term memory, long-term memory
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