TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

<i>TREM2</i> Variants in Alzheimer's Disease

Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020 · see citing works

Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736 · see citing works

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

Takahashi, K., Rochford, C. D. P., & Neumann, H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041611 · Cited by 1,124 · see citing works

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Kleinberger, G., Yamanishi, Y., Suárez-Calvet, M., Czirr, E., Lohmann, E., Cuyvers, E., Struyfs, H., Pettkus, N., Wenninger-Weinzierl, A., Mazaheri, F., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009093 · Cited by 798 · see citing works

TREMs in the immune system and beyond

Colonna, M. (2003) · Nature Reviews Immunology · doi:10.1038/nri1106 · Cited by 701 · see citing works

Alternatively activated microglia and macrophages in the central nervous system

Franco, R., & Fernández‐Suárez, D. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.003 · Cited by 650 · see citing works

TREM2 sustains microglial expansion during aging and response to demyelination

Poliani, P. L., Wang, Y., Fontana, E., Robinette, M. L., Yamanishi, Y., Gilfillan, S., & Colonna, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77983 · Cited by 525 · see citing works

Synaptic degeneration in Alzheimer's disease

Arendt, T. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0536-x · Cited by 517 · see citing works

TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis

Takahashi, K., Prinz, M., Stagi, M., Chechneva, O., & Neumann, H. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040124 · Cited by 414 · see citing works

GSK-3 is essential in the pathogenesis of Alzheimer's disease

Takashima, A. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s335 · Cited by 395 · see citing works

Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an alzheimer’s mouse model

Ghosh, S., Wu, M. D., Shaftel, S. S., Kyrkanides, S., LaFerla, F. M., Olschowka, J. A., & O'Banion, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4361-12.2013 · Cited by 390 · see citing works

GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease

Cruchaga, C., Kauwe, J. S. K., Harari, O., Jin, S. C., Cai, Y., Karch, C. M., Benitez, B. A., Jeng, A. T., Skorupa, T., Carrell, D., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.026 · Cited by 383 · see citing works

Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke

Kawabori, M., Kacimi, R., Kauppinen, T., Calosing, C., Kim, J. Y., Hsieh, C. L., Nakamura, M. C., & Yenari, M. A. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2620-14.2015 · Cited by 375 · see citing works

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

Jiang, T., Tan, L., Zhu, X.-C., Zhang, Q.-Q., Cao, L., Tan, M.-S., Gu, L.-Z., Wang, H.-F., Ding, Z.-Z., Zhang, Y.-D., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.164 · Cited by 320 · see citing works

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

Lee, D. C., Rizer, J., Selenica, M.-L. B., Reid, P., Kraft, C., Johnson, A., Blair, L., Gordon, M. N., Dickey, C. A., & Morgan, D. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-56 · Cited by 293 · see citing works

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

Martin, L., Latypova, X., Wilson, C. M., Magnaudeix, A., Perrin, M.-L., & Terro, F. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.008 · Cited by 249 · see citing works

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

Frank, S., Burbach, G. J., Bonin, M., Walter, M., Streit, W., Bechmann, I., & Deller, T. (2008) · Glia · doi:10.1002/glia.20710 · Cited by 247 · see citing works

TREM2 and the neuroimmunology of Alzheimer's disease

Hickman, S. E., & El Khoury, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.11.021 · Cited by 221 · see citing works

Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease

Dodart, J.-C., Marr, R. A., Koistinaho, M., Gregersen, B. M., Malkani, S., Verma, I. M., & Paul, S. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409072102 · Cited by 207 · see citing works

The role of <i>TREM2</i> R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

Lill, C. M., Rengmark, A., Pihlstrøm, L., Fogh, I., Shatunov, A., Sleiman, P. M., Wang, L., Liu, T., Lassen, C. F., Meissner, E., et al. (2015) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2014.12.009 · Cited by 205 · see citing works

Cdk5 activity in the brain – multiple paths of regulation

Shah, K., & Lahiri, D. K. (2014) · Journal of Cell Science · doi:10.1242/jcs.147553 · Cited by 196 · see citing works

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

Laurent, C., Burnouf, S., Ferry, B., Batalha, V. L., Coelho, J. E., Baqi, Y., Malik, E. M., Mariciniak, E., Parrot, S., der Jeugd, A. V., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.151 · Cited by 188 · see citing works

Accumulation of tau induced in neurites by microglial proinflammatory mediators

Gorlovoy, P., Larionov, S., Pham, T. T. H., & Neumann, H. (2009) · The FASEB Journal · doi:10.1096/fj.08-123877 · Cited by 156 · see citing works

<scp>TREM</scp>2 Protein Expression Changes Correlate with <scp>A</scp>lzheimer's Disease Neurodegenerative Pathologies in Post‐Mortem Temporal Cortices

Lue, L., Schmitz, C. T., Serrano, G., Sue, L. I., Beach, T. G., & Walker, D. G. (2015) · Brain Pathology · doi:10.1111/bpa.12190 · Cited by 154 · see citing works

Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A)

Sun, X., Wei, Y., Xiong, Y., Wang, X., Xie, A., Wang, X., Yang, Y., Wang, Q., Lu, Y., Liu, R., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.309070 · Cited by 137 · see citing works

DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response

Zhong, L., Chen, X.-F., Zhang, Z.-L., Wang, Z., Shi, X.-Z., Xu, K., Zhang, Y.-W., Xu, H., & Bu, G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.645986 · Cited by 133 · see citing works

Cdk5: Multitasking between physiological and pathological conditions

Lopes, J. P., & Agostinho, P. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.03.006 · Cited by 129 · see citing works

Therapeutic strategies for tau mediated neurodegeneration

Yoshiyama, Y., Lee, V. M. ‐., & Trojanowski, J. Q. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303144 · Cited by 129 · see citing works

Connecting the dots between tau dysfunction and neurodegeneration

Frost, B., Götz, J., & Feany, M. B. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.07.005 · Cited by 124 · see citing works

Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance

Jiang, T., Yu, J., Zhu, X., Zhang, Q.-Q., Cao, L., Wang, H.-F., Tan, M., Gao, Q., Qin, H., Zhang, Y., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.032 · Cited by 118 · see citing works

TREM2 in Alzheimer’s disease

Jiang, T., Yu, J., Zhu, X., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8424-8 · Cited by 118 · see citing works

TYROBP in Alzheimer’s Disease

Ma, J., Jiang, T., Tan, L., & Yu, J.-T. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8811-9 · Cited by 113 · see citing works

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice

Jiang, T., Tan, L., Zhu, X.-C., Zhou, J.-S., Cao, L., Tan, M.-S., Wang, H.-F., Chen, Q., Zhang, Y.-D., & Yu, J.-T. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.08.019 · Cited by 111 · see citing works

Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice

Jiang, T., Yu, J., Zhu, X., Tan, M., Gu, L.-Z., Zhang, Y., & Tan, L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.026 · Cited by 97 · see citing works

IL12/23 p40 Inhibition Ameliorates Alzheimer's Disease-Associated Neuropathology and Spatial Memory in SAMP8 Mice

Tan, M., Yu, J., Jiang, T., Zhu, X., Guan, H., & Tan, L. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-131148 · Cited by 80 · see citing works

Memory deficits correlate with tau and spine pathology in P 301 S MAPT transgenic mice

Xu, H. W., Rösler, T. W., Carlsson, T., de Andrade, A., Bruch, J., Höllerhage, M., Oertel, W. H., & Höglinger, G. U. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12160 · Cited by 57 · see citing works

Improving planning, design, reporting and scientific quality of animal experiments by using the Gold Standard Publication Checklist, in addition to the ARRIVE guidelines

Hooijmans, C. R., de Vries, R. B. M., Leenaars, M., Curfs, J. H. A. J., & Ritskes-Hoitinga, M. J. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01128.x · Cited by 56 · see citing works

Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice

Chu, J., Li, J. G., Giannopoulos, P. F., Blass, B. E., Childers, W. E., Abou-Gharbia, M. A., & Praticò, D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.170 · Cited by 42 · see citing works

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. (2018) · Cell · doi:10.1016/j.cell.2018.05.003 · Cited by 1,474 · see citing works

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

Shi, Y., & Holtzman, D. M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0051-1 · Cited by 595 · see citing works

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

van der Kant, R., Goldstein, L. S. B., & Ossenkoppele, R. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0240-3 · Cited by 580 · see citing works

Inflammatory Response in the CNS: Friend or Foe?

Sochocka, M., Diniz, B. S., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0297-1 · Cited by 573 · see citing works

New insights into the role of TREM2 in Alzheimer’s disease

Gratuze, M., Leyns, C. E. G., & Holtzman, D. M. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0298-9 · Cited by 489 · see citing works

TREM2 in Neurodegenerative Diseases

Jay, T. R., von Saucken, V. E., & Landreth, G. E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0197-5 · Cited by 427 · see citing works

Tau and neuroinflammation: what impact for Alzheimer's disease and tauopathies?

Laurent, C., Buée, L., & Blum, D. (2018) · Biomedical Journal · doi:10.1016/j.bj.2018.01.003 · Cited by 348 · see citing works

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Henstridge, C. M., Hyman, B. T., & Spires-Jones, T. L. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0113-1 · Cited by 348 · see citing works

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Ewers, M., Franzmeier, N., Suárez-Calvet, M., Morenas-Rodriguez, E., Caballero, M. A. A., Kleinberger, G., Piccio, L., Cruchaga, C., Deming, Y., Dichgans, M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav6221 · Cited by 327 · see citing works

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

Zhang, Y., Wang, D., Xu, S., Zhang, S., Fan, Y., Yang, Y., Guo, S., Wang, S., Guo, T., Wang, Z., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.11.001 · Cited by 307 · see citing works

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

Hopp, S. C., Lin, Y., Oakley, D., Roe, A. D., DeVos, S. L., Hanlon, D., & Hyman, B. T. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1309-z · Cited by 286 · see citing works

TREM2-Ligand Interactions in Health and Disease

Kober, D. L., & Brett, T. J. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.04.004 · Cited by 284 · see citing works

TREM2, microglia, and Alzheimer’s disease.

Qin, Q., Teng, Z., Liu, C., Li, Q., Yin, Y., & Tang, Y. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111438 · Cited by 219 · see citing works

The role of the immune system in Alzheimer disease: Etiology and treatment

Jevtic, S. D., Sengar, A. S., Salter, M. W., & McLaurin, J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.08.005 · Cited by 218 · see citing works

Intersection of pathological tau and microglia at the synapse

Vogels, T., Murgoci, A.-N., & Hromádka, T. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0754-y · Cited by 197 · see citing works

Treadmill Exercise Exerts Neuroprotection and Regulates Microglial Polarization and Oxidative Stress in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer’s Disease

Lu, Y., Dong, Y., Tucker, D., Wang, R., Ahmed, M. E., Brann, D. W., & Zhang, Q. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160869 · Cited by 214 · see citing works

The impact of high and low dose ionising radiation on the central nervous system

Betlazar, C., Middleton, R. J., Banati, R. B., & Liu, G.-J. (2016) · Redox Biology · doi:10.1016/j.redox.2016.08.002 · Cited by 191 · see citing works

Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis

Zhou, M., Xu, R., Kaelber, D. C., & Gurney, M. E. (2020) · PLOS ONE · doi:10.1371/journal.pone.0229819 · Cited by 157 · see citing works

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

Lessard, C. B., Malnik, S. L., Zhou, Y., Ladd, T. B., Cruz, P. E., Ran, Y., Chakrabaty, P., Mahan, T. E., Holtzman, D. M., Ulrich, J. D., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809027 · Cited by 151 · see citing works

TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease

Zhang, Y., Feng, S., Nie, K., Li, Y., Gao, Y., Gan, R., Wang, L., Li, B., Sun, X., Wang, L., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.226 · Cited by 152 · see citing works

Microglial polarization: novel therapeutic mechanism against Alzheimer’s disease

Yao, K., & Zu, H. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00613-5 · Cited by 146 · see citing works

Pharmacological Targeting of Microglial Activation: New Therapeutic Approach

Liu, C., Wang, X., Liu, C., & Zhang, H. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00514 · Cited by 141 · see citing works

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

Ewers, M., Biechele, G., Suárez‐Calvet, M., Sacher, C., Blume, T., Morenas‐Rodriguez, E., Deming, Y., Piccio, L., Cruchaga, C., Kleinberger, G., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012308 · Cited by 133 · see citing works

Markers of neuroinflammation associated with Alzheimer’s disease pathology in older adults

Popp, J., Oikonomidi, A., Tautvydaitė, D., Dayon, L., Bacher, M., Migliavacca, E., Henry, H., Kirkland, R., Severin, I., Wojcik, J., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.01.020 · Cited by 136 · see citing works

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

Pinto, S., Cunha, C., Barbosa, M., Vaz, A. R., & Brites, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00273 · Cited by 135 · see citing works

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology

Haure-Mirande, J.-V., Audrain, M., Fanutza, T., Kim, S. H., Klein, W. L., Glabe, C., Readhead, B., Dudley, J. T., Blitzer, R. D., Wang, M., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1737-3 · Cited by 127 · see citing works

TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease

Li, Y., Xu, H., Wang, H., Yang, K., Luan, J., & Wang, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115218 · Cited by 128 · see citing works

Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis

Teter, B., Morihara, T., Lim, G. P., Chu, T., Jones, M. R., Zuo, X., Paul, R. M., Frautschy, S. A., & Cole, G. M. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.02.015 · Cited by 125 · see citing works

TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease

Ren, M., Guo, Y., Wei, X., Yan, S., Qin, Y., Zhang, X., Jiang, F., & Lou, H. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.01.016 · Cited by 118 · see citing works

Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer’s Disease and Multiple Sclerosis

Maleki, A. F., & Rivest, S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00355 · Cited by 116 · see citing works

TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway

Ruganzu, J. B., Zheng, Q., Wu, X., He, Y., Peng, X., Jin, H., Zhou, J., Ma, R., Ji, S., Ma, Y., et al. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113506 · Cited by 116 · see citing works

TREM2 ectodomain and its soluble form in Alzheimer’s disease

Yang, J., Fu, Z., Zhang, X., Xiong, M., Meng, L., & Zhang, Z. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01878-2 · Cited by 113 · see citing works

TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells

Huang, P., Zhang, Z., Zhang, P., Feng, J., Xie, J., Zheng, Y., Liang, X., Zhu, B., Chen, Z., Feng, S., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03713-0 · Cited by 111 · see citing works

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

Lü, Z., Shen, J., Yang, H. J., Wang, J., Zhao, R., Zhang, T.-L., Guo, J. R., & Zhang, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01298-z · Cited by 108 · see citing works

Role of Microglial Cells in Alzheimer’s Disease Tau Propagation

Španić, E., Horvat, L. L., Hof, P. R., & Šimić, G. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00271 · Cited by 107 · see citing works

MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease

Liang, C., Zou, T., Zhang, M., Fan, W., Zhang, T., Jiang, Y., Cai, Y., Chen, F., Chen, X., Sun, Y., et al. (2021) · Theranostics · doi:10.7150/thno.53418 · Cited by 104 · see citing works

Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice

Han, X., Cheng, X., Xu, J., Liu, Y., Zhou, J., Jiang, L., Gu, X., & Xia, T. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109231 · Cited by 94 · see citing works

Partial reduction of microglia does not affect tau pathology in aged mice

Bennett, R. E., Bryant, A., Hu, M., Robbins, A. B., Hopp, S. C., & Hyman, B. T. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1348-5 · Cited by 91 · see citing works

TREM1 facilitates microglial phagocytosis of amyloid beta

Jiang, T., Zhang, Y.-D., Gao, Q., Zhou, J.-S., Zhu, X.-C., Lu, H., Shi, J.-Q., Tan, L., Chen, Q., & Yu, J.-T. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1622-5 · Cited by 91 · see citing works

Microglial Phenotypic Transition: Signaling Pathways and Influencing Modulators Involved in Regulation in Central Nervous System Diseases

Li, J., Shui, X., Sun, R., Wan, L., Zhang, B., Xiao, B., & Luo, Z. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.736310 · Cited by 90 · see citing works

A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature

Dardiotis, E., Siokas, V., Pantazi, E., Dardioti, M., Rikos, D., Xiromerisiou, G., Markou, A., Papadimitriou, D. A., Speletas, M. G., & Hadjigeorgiou, G. M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.015 · Cited by 89 · see citing works

Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice

Hu, L.-Y., Zhou, Y., Cui, W., Hu, X., Du, L., Mi, W., Chu, Y., Wu, G.-C., Wang, Y., & Mao‐Ying, Q. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.011 · Cited by 88 · see citing works

Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration

Yang, G., Xu, X., Gao, W., Wang, X., Zhao, Y., & Xu, Y. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1700692 · Cited by 85 · see citing works

Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer’s disease

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Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

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