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The modulatory effects of nicotine on parietal cortex activity in a cued target detection task depend on cue reliability
Abstract
This functional magnetic resonance imaging study investigates the effects of nicotine in a cued target detection task when changing cue reliability. Fifteen non-smoking volunteers were studied under placebo and nicotine (Nicorette polacrilex gum 1 and 2 mg). Validly and invalidly cued trials were arranged in blocks with high, middle and low cue reliability. Two effects of nicotine were investigated: its influence on i) parietal cortex activity underlying the processing of invalid vs. valid trials (i.e. validity effect) and ii) neural activity in the context of low, middle and high informative value of the cue (i.e. cue reliability effect). Nicotine did not affect behavioral performance. However, nicotine reduced the difference in the blood oxygenation level dependent (BOLD) signal between invalid and valid trials in the right intraparietal sulcus. The reduction of parietal activity in invalid trials was smaller in the low cue reliability condition. The same posterior parietal region exhibited a nicotinic modulation of BOLD activity in valid trials which was dependent on cue reliability: Nicotine specifically enhanced the neural activity during valid trials in the context of low cue reliability, i.e. when subjects are already in a state of low certainty. We speculate that the right intraparietal sulcus might be part of two networks working in parallel: one responsible for reorienting attention and the other for the cholinergic modulation of cue reliability. By reducing the use of the cue, nicotine modulates parietal activity related to reorienting attention in conditions with higher cue certainty. On the other hand, nicotine increases parietal activity in states of low certainty. This enhanced activation might influence brain regions, such as the posterior cingulate, directly involved in the processing of cue reliability.
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“However, consistent with the conclusions derived from experiments in rodents, nicotine enhanced neuronal activity in prefrontal cingulate and parietal regions specifically in trials requiring cue detection and attentional re-orienting in subjects performing a cued target detection task (Giessing et al, 2006; Vossel et al, 2008).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Giessing et al, 2006
In the citing paper
“Similar to the purely behavioral studies discussed above, administration of nicotine to subjects undergoing fMRI scanning did not consistently produce significant effects on cognitive performance (Giessing et al, 2006; Thiel and Fink, 2008; Vossel et al, 2008).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Giessing et al, 2006
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Metadata
- Authors
- Giessing, C., Thiel, C. M., Rösler, F., & Fink, G. R.
- Affiliations
- Forschungszentrum Jülich (DE)
- Philipps University of Marburg (DE)
- Corresponding author
- Giessing, C.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 137
- Issue
- 3
- Pages
- 853-864
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1969045263
- Cited by
- 104
- References
- 60
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 6 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 9 · 2012: 10
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- nicotine, parietal cortex, intraparietal sulcus, cue reliability, target detection, validity effect, attentional reorienting, cholinergic modulation, BOLD signal, posterior cingulate cortex, non-smokers
- MeSH terms
- Adult, Attention, Cues, Data Interpretation, Statistical, Dose-Response Relationship, Drug, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Learning, Magnetic Resonance Imaging, Male, Nicotine, Oxygen, Parietal Lobe, Photic Stimulation, Psychomotor Performance, Reaction Time, Nicotinic Agonists
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