Effects of the cholinergic agonist nicotine on reorienting of visual spatial attention and top-down attentional control

Thiel, C.M.; Fink, G.R.

doi:10.1016/j.neuroscience.2007.10.061

Cited by 97Nicotinic Acetylcholine Receptors StudyVisual perception and processing mechanismsNeural and Behavioral Psychology Studies

Effects of the cholinergic agonist nicotine on reorienting of visual spatial attention and top-down attentional control

Thiel, C.M., Fink, G.R.·2008·Neuroscience

DOI 10.1016/j.neuroscience.2007.10.061

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Abstract

The cholinergic agonist nicotine facilitates detection of invalidly cued trials in location-cueing paradigms and reduces the associated neural activity in human inferior parietal cortex. By using functional magnetic resonance imaging we test the hypothesis that the nicotinic modulation of attentional reorienting may result from reduced use of top-down information derived from prior cues. In a within subjects design non-smoking volunteers were given either placebo or nicotine (Nicorette 2 mg gum) prior to performing a cued target discrimination task. Attention was either validly (80%) or invalidly (20%) cued to the right or left visual hemifield. The difference in reaction times to invalidly and validly cued targets is termed the 'validity effect' and indicates the costs for attentional reorienting. Nicotine reduced the validity effect and reorienting-related neural activity in right inferior parietal cortex. Further regions consistently modulated in their activity by nicotine were the right middle temporal gyrus, left middle frontal gyrus, left parahippocampal gyrus and right cerebellum. The effects of nicotine upon top-down modulation were investigated by comparing occipital activity when attending to the right vs. left visual hemifield under placebo and nicotine. If nicotine reduced the use of top-down information attentional modulation in occipital cortex should be smaller under nicotine as compared with placebo. Even though an attention-related modulation of neural activity was observed in the fusiform and middle occipital gyrus we found no evidence for differences in attentional modulation under placebo and nicotine. Our data support a role of nicotinic cholinergic receptors in facilitating several subcomponents of attentional reorienting via modulation of right inferior parietal, temporal and frontal brain activity. In contrast, the findings in the occipital cortex do not support the hypothesis that the effects of nicotine on attentional reorienting are due to reduced reliance on top-down information derived from prior cues.

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Administration of nicotine to subjects undergoing fMRI scanning did not consistently produce significant effects on cognitive performance.
“Similar to the purely behavioral studies discussed above, administration of nicotine to subjects undergoing fMRI scanning did not consistently produce significant effects on cognitive performance (Giessing et al, 2006; Thiel and Fink, 2008; Vossel et al, 2008).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Thiel and Fink, 2008

Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881 · see citing works
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688 · see citing works
Orienting of Attention
Posner, M. I. (1980) · Quarterly Journal of Experimental Psychology · doi:10.1080/00335558008248231 · Cited by 9,670 · see citing works
Neural Mechanisms of Selective Visual Attention
Desimone, R., & Duncan, J. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.001205 · Cited by 8,388 · see citing works
Mechanisms of visual attention in the human cortex
Ungerleider, S. K. A. L. G. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.315 · Cited by 2,159 · see citing works
The neural mechanisms of top-down attentional control
Hopfinger, J. B., Buonocore, M. H., & Mangun, G. R. (2000) · Nature Neuroscience · doi:10.1038/72999 · Cited by 1,876 · see citing works
Voluntary orienting is dissociated from target detection in human posterior parietal cortex
Corbetta, M., Kincade, J. M., Ollinger, J. M., McAvoy, M. P., & Shulman, G. L. (2000) · Nature Neuroscience · doi:10.1038/73009 · Cited by 1,816 · see citing works
Uncertainty, Neuromodulation, and Attention
Yu, A. J., & Dayan, P. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.026 · Cited by 1,774 · see citing works
Increased Activity in Human Visual Cortex during Directed Attention in the Absence of Visual Stimulation
Kastner, S., Pinsk, M. A., De Weerd, P., Desimone, R., & Ungerleider, L. G. (1999) · Neuron · doi:10.1016/s0896-6273(00)80734-5 · Cited by 1,622 · see citing works
Combined spatial and temporal imaging of brain activity during visual selective attention in humans
Heinze, H. –., Mangun, G. R., Burchert, W., Hinrichs, H., Scholz, M., Münte, T. F., Gös, A., Scherg, M., Johannes, S., Hundeshagen, H., et al. (1994) · Nature · doi:10.1038/372543a0 · Cited by 915 · see citing works
Attentional Activation of the Cerebellum Independent of Motor Involvement
Allen, G., Buxton, R. B., Wong, E. C., & Courchesne, E. (1997) · Science · doi:10.1126/science.275.5308.1940 · Cited by 785 · see citing works
Brain Mapping: The Methods
(2002) · Elsevier eBooks · doi:10.1016/b978-0-12-693019-1.x5000-x · Cited by 713 · see citing works
Neural Systems for Visual Orienting and Their Relationships to Spatial Working Memory
Corbetta, M., Kincade, J. M., & Shulman, G. L. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902317362029 · Cited by 698 · see citing works
Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection
Sarter, M., Hasselmo, M. E., Bruno, J. P., & Givens, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.006 · Cited by 667 · see citing works
Where in the brain does visual attention select the forest and the trees?
Fink, G. R., Halligan, P. W., Marshall, J. C., Frith, C., Frackowiak, R. S. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/382626a0 · Cited by 626 · see citing works
Self-citation
Nicotine absorption and cardiovascular effects with smokeless tobacco use: Comparison with cigarettes and nicotine gum
Benowitz, N. L., Porchet, H., Sheiner, L., & Jacob, P. (1988) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1988.107 · Cited by 619 · see citing works
Conjunction revisited
Friston, K. J., Penny, W. D., & Glaser, D. E. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.013 · Cited by 578 · see citing works
Event-related functional magnetic resonance imaging: modelling, inference and optimization
Josephs, O., & Henson, R. N. A. (1999) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1999.0475 · Cited by 425 · see citing works
Cerebral correlates of alerting, orienting and reorienting of visuospatial attention: an event-related fMRI study
Thiel, C. M., Zilles, K., & Fink, G. R. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.08.044 · Cited by 303 · see citing works
Self-citation
Putting spatial attention on the map: timing and localization of stimulus selection processes in striate and extrastriate visual areas
Martı́nez, A., Russo, F. D., Anllo‐Vento, L., Sereno, M. I., Buxton, R. B., & Hillyard, S. A. (2001) · Vision Research · doi:10.1016/s0042-6989(00)00267-4 · Cited by 280 · see citing works
Neural Mechanisms of Visual Attention: Object-Based Selection of a Region in Space
Arrington, C. M., Carr, T. H., Mayer, A. R., & Rao, S. M. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900563975 · Cited by 276 · see citing works
Towards a model of the mind's eye's movement.
Jonides, J. (1980) · Canadian Journal of Psychology/Revue Canadienne de Psychologie · doi:10.1037/h0081031 · Cited by 274 · see citing works
Quantitative Analysis of Cyto- and Receptor Architecture of the Human Brain
Zilles, K., Schleicher, A., Palomero‐Gallagher, N., & Amunts, K. (2002) · Elsevier eBooks · doi:10.1016/b978-012693019-1/50023-x · Cited by 271 · see citing works
Delayed Striate Cortical Activation during Spatial Attention
Noesselt, T., Hillyard, S. A., Woldorff, M. G., Schoenfeld, M. A., Hagner, T., Jäncke, L., Tempelmann, C., Hinrichs, H., & Heinze, H. (2002) · Neuron · doi:10.1016/s0896-6273(02)00781-x · Cited by 263 · see citing works
Posterior probability maps and SPMs
Friston, K. J., & Penny, W. D. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00144-7 · Cited by 240 · see citing works
Cognitive effects of nicotine in humans: an fMRI study
Kumari, V., Gray, J. A., Ffytche, D. H., Mitterschiffthaler, M. T., Das, M., Zachariah, E., Vythelingum, G. N., Williams, S., Simmons, A., & Sharma, T. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00110-1 · Cited by 237 · see citing works
Cue validity modulates the neural correlates of covert endogenous orienting of attention in parietal and frontal cortex
Vossel, S., Thiel, C. M., & Fink, G. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.019 · Cited by 228 · see citing works
Self-citation
Nicotine Enhances Visuospatial Attention by Deactivating Areas of the Resting Brain Default Network
Hahn, B., Ross, T. J., Yang, Y., Kim, I., Huestis, M. A., & Stein, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5129-06.2007 · Cited by 199 · see citing works
Effects of altering brain cholinergic activity on covert orienting of attention: comparison of monkey and human performance
Witte, E. A., Davidson, M. C., & Marrocco, R. T. (1997) · Psychopharmacology · doi:10.1007/s002130050352 · Cited by 187 · see citing works
Nicotine modulates reorienting of visuospatial attention and neural activity in human parietal cortex
Thiel, C. M., Zilles, K., & Fink, G. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300633 · Cited by 182 · see citing works
Self-citation
Effects of acute nicotine administration on behavioral inhibition in adolescents with attention-deficit/hyperactivity disorder
Potter, A., & NEWHOUSE, P. A. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1874-y · Cited by 180 · see citing works
Effects of Cholinergic Enhancement on Visual Stimulation, Spatial Attention, and Spatial Working Memory
Bentley, P., Masud Husain, B., & Dolan, R. J. (2004) · Neuron · doi:10.1016/s0896-6273(04)00145-x · Cited by 179 · see citing works
Dissociation of Stimulus Relevance and Saliency Factors during Shifts of Visuospatial Attention
Indovina, I., & Macaluso, E. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl081 · Cited by 171 · see citing works
Covert Reorienting and Inhibition of Return: An Event-Related fMRI Study
Lepsien, J., & Pollmann, S. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902317236795 · Cited by 161 · see citing works
The temporal dynamics of the effects in occipital cortex of visual-spatial selective attention
Woldorff, M. G., Mario Liotti, A., Seabolt, M., Busse, L., Lancaster, J., & Fox, P. T. (2002) · Cognitive Brain Research · doi:10.1016/s0926-6410(02)00212-4 · Cited by 133 · see citing works
Prefrontal cortical modulation of acetylcholine release in posterior parietal cortex
Nelson, C. L., Sarter, M., & Bruno, J. P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.007 · Cited by 128 · see citing works
Cholinergic neurotransmission influences covert orientation of visuospatial attention in the rat
Phillips, J. M., McAlonan, K., Robb, W. G. K., & Brown, V. J. (2000) · Psychopharmacology · doi:10.1007/s002130000437 · Cited by 107 · see citing works
The modulatory effects of nicotine on parietal cortex activity in a cued target detection task depend on cue reliability
Giessing, C., Thiel, C. M., Rösler, F., & Fink, G. R. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.005 · Cited by 104 · see citing works
Self-citation
Cerebral effects of nicotine during cognition in smokers and non-smokers
Ghatan, P. H., Ingvar, M., Eriksson, L., Stone‐Elander, S., Serrander, M., Ekberg, K., & Wahren, J. (1998) · Psychopharmacology · doi:10.1007/s002130050554 · Cited by 93 · see citing works
A double-blind placebo-controlled experimental study of nicotine: II—Effects on response inhibition and executive functioning
Dawkins, L., Powell, J. H., West, R., Powell, J., & Pickering, A. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0634-6 · Cited by 85 · see citing works
Distribution of muscarinic receptor subtypes within architectonic subregions of the primate cerebral cortex
Mash, D. C., White, W. F., & Mesulam, M. M. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902780209 · Cited by 84 · see citing works
Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects
Vossel, S., Thiel, C. M., & Fink, G. R. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301469 · Cited by 81 · see citing works
Self-citation
Bayesian second-level analysis of functional magnetic resonance images
Neumann, J., & Lohmann, G. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00443-9 · Cited by 79 · see citing works
The effects of nicotine on spatial and non-spatial expectancies in a covert orienting task
Murphy, F. C., & Klein, R. M. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(98)00012-8 · Cited by 75 · see citing works
Visuospatial Attention Shift and Motor Responses in Cerebellar Disorders
Yamaguchi, S., Tsuchiya, H., & Kobayashi, S. (1998) · Journal of Cognitive Neuroscience · doi:10.1162/089892998563806 · Cited by 64 · see citing works
Nicotine effects on alertness and spatial attention in non-smokers
Griesar, W. S., Zajdel, D. P., & Oken, B. (2002) · Nicotine & Tobacco Research · doi:10.1080/14622200210123617 · Cited by 64 · see citing works
Muscarinic Versus Nicotinic Modulation of a Visual Task A PET Study Using Drug Probes
Mentis, M. J. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00264-0 · Cited by 62 · see citing works
Impact of intravenous nicotine on BOLD signal response to photic stimulation
Jacobsen, L. K., Gore, J. C., Skudlarski, P., Lacadie, C., Jatlow, P. L., & Krystal, J. H. (2002) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(02)00494-0 · Cited by 60 · see citing works
Effects of nicotine on visuo-spatial selective attention as indexed by event-related potentials
Meinke, A., Thiel, C. M., & Fink, G. R. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.072 · Cited by 50 · see citing works
Self-citation
Cholinergic modulation of covert attention in the rat
Stewart, C., Burke, S., & Marrocco, R. T. (2001) · Psychopharmacology · doi:10.1007/s002130100692 · Cited by 47 · see citing works
Nicotine improves antisaccade task performance without affecting prosaccades
Larrison, A. L., Briand, K. A., & Sereno, A. B. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.604 · Cited by 36 · see citing works
Cardiovascular effects of nicotine chewing gum in healthy non-smokers
Nyberg, G., Panfilov, V., Sivertsson, R., & Wilhelmsen, L. (1982) · European Journal of Clinical Pharmacology · doi:10.1007/bf00613610 · Cited by 33 · see citing works
Common modules for processing invalidly cued events in the human cortex
Mattler, U., Wüstenberg, T., & Heinze, H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.051 · Cited by 8 · see citing works
The effect of smoking/nicotine on response selection
Houlihan, M., Pritchard, W. S., & Robinson, J. H. (1999) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/(sici)1099-1077(199901)14:1 · Cited by 5 · see citing works
Identifying global anatomical differences: Deformation-based morphometry
(1998) · doi:10.1002/(sici)1097-0193(1998)6:5/6

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Heishman, S. J., Kleykamp, B. A., & Singleton, E. G. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1848-1 · Cited by 651 · see citing works
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Sofouglu, M., Herman, A. I., Robinson, C. D., & Waters, A. J. (2014) · Lincoln (University of Nebraska) · Cited by 417 · see citing works
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Moran, R. J., Campo, P., Symmonds, M., Stephan, K. E., Dolan, R. J., & Friston, K. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4255-12.2013 · Cited by 312 · see citing works
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Bayesian Prediction and Evaluation in the Anterior Cingulate Cortex
Ide, J. S., Shenoy, P., Yu, A. J., & Li, C.-S. R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2201-12.2013 · Cited by 185 · see citing works
Cholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging
Bentley, P., Driver, J., & Dolan, R. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.06.002 · Cited by 173 · see citing works
Dual role of nicotine in addiction and cognition: A review of neuroimaging studies in humans
Jasinska, A. J., Zorick, T. S., Brody, A. L., & Stein, E. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.02.015 · Cited by 163 · see citing works
nAChR agonist-induced cognition enhancement: Integration of cognitive and neuronal mechanisms
Sarter, M., Parikh, V., & Howe, W. M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.019 · Cited by 123 · see citing works
Nicotine effects on default mode network during resting state
Tanabe, J., Nyberg, E. M., Martín, L., Martin, J., Cordes, D., Kronberg, E., & Tregellas, J. R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2221-8 · Cited by 113 · see citing works
Anatomy and White Matter Connections of the Middle Frontal Gyrus
Briggs, R. G., Lin, Y., Dadario, N. B., Kim, S. J., Young, I. M., Bai, M. Y., Dhanaraj, V., Fonseka, R. D., Hormovas, J., Tanglay, O., et al. (2021) · World Neurosurgery · doi:10.1016/j.wneu.2021.03.045 · Cited by 112 · see citing works
Prompt but inefficient: nicotine differentially modulates discrete components of attention
Vangkilde, S., Bundesen, C., & Coull, J. T. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2361-x · Cited by 101 · see citing works
Dopaminergic and cholinergic modulations of visual-spatial attention and working memory: Insights from molecular genetic research and implications for adult cognitive development.
Störmer, V. S., Passow, S., Biesenack, J., & Li, S. (2011) · Developmental Psychology · doi:10.1037/a0026198 · Cited by 85 · see citing works
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Effects of nicotine on novelty detection and memory recognition performance: double-blind, placebo-controlled studies of smokers and nonsmokers
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A Novel Mechanism for Nicotinic Potentiation of Glutamatergic Synapses
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Is There a Canonical Cortical Circuit for the Cholinergic System? Anatomical Differences Across Common Model Systems
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Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition
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The Neural Mechanisms Underlying the Acute Effect of Cigarette Smoking on Chronic Smokers
Wang, K., Yang, J., Zhang, S., Wei, D., Hao, X., Tu, S., & Qiu, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102828 · Cited by 38 · see citing works
Effects of acute nicotine on event-related potential and performance indices of auditory distraction in nonsmokers
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Electrophysiological evidence of nicotine’s distracter-filtering properties in non-smokers
Knott, V., Heenan, A., Shah, D. K., Bolton, K., Fisher, D. J., & Villeneuve, C. M. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109348158 · Cited by 35 · see citing works
Smoking abstinence and depressive symptoms modulate the executive control system during emotional information processing
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Genome-Wide DNA Methylation and Gene Expression Analyses of Monozygotic Twins Discordant for Intelligence Levels
Yu, C.-C., Furukawa, M. T., Kobayashi, K., Shikishima, C., Cha, P.-C., Jun, S.-S., Sugawara, H., Iwamoto, K., Kato, T., Ando, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047081 · Cited by 40 · see citing works
Guanfacine potentiates the activation of prefrontal cortex evoked by warning signals
Clerkin, S. M., Schulz, K. P., Halperin, J. M., Newcorn, J. H., Ivanov, I., Tang, C. Y., & Fan, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.013 · Cited by 28 · see citing works
Neural correlates of executive function and attention in children with ADHD: An ALE meta-analysis of task-based functional connectivity studies
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Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study
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Acute effects of nicotine administration during prospective memory, an event related fMRI study
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Pro-cognitive drug effects modulate functional brain network organization
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Self-citation
Change is in the eye of the beholder
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Direction and magnitude of nicotine effects on the fMRI BOLD response are related to nicotine effects on behavioral performance
Warbrick, T., Mobascher, A., Brinkmeyer, J., Musso, F., Stöcker, T., Shah, N. J., Vossel, S., & Winterer, G. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2145-8 · Cited by 24 · see citing works
Neuronal effects of nicotine during auditory selective attention
Smucny, J., D, A. O. M., Eichman, L. C., & Tregellas, J. R. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3832-7 · Cited by 22 · see citing works
Nicotine acutely alters temporal properties of resting brain states
Wang, K. S., Brown, K., Frederick, B. B., Moran, L. V., Olson, D. P., Pizzagalli, D. A., Kaiser, R. H., & Janes, A. C. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.108846 · Cited by 22 · see citing works
APOE E4 Carriers Show Prospective Memory Enhancement Under Nicotine, and Evidence for Specialisation Within Medial BA10
Evans, S., Gray, M. A., Dowell, N. G., Tabet, N., Tofts, P. S., King, S. L., & Rusted, J. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.230 · Cited by 22 · see citing works
Treatment with a nicotine vaccine does not lead to changes in brain activity during smoking cue exposure or a working memory task
Havermans, A., Vuurman, E. F. P. M., van den Hurk, J., Hoogsteder, P., & van Schayck, O. C. P. (2014) · Addiction · doi:10.1111/add.12577 · Cited by 22 · see citing works
Nicotine Enhances Alerting, but not Executive, Attention in Smokers and Nonsmokers
Myers, C. S., Taylor, R. C., Salmeron, B. J., Waters, A. J., & Heishman, S. J. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts108 · Cited by 20 · see citing works
Haloperidol 2 mg impairs inhibition but not visuospatial attention
Logemann, H. N. A., Böcker, K. B. E., Deschamps, P. K. H., van Harten, P. N., Koning, J., Kemner, C., Logemann-Molnár, Z., & Kenemans, J. L. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4454-z · Cited by 21 · see citing works
Nicotine and Attention: Event-Related Potential Investigations in Nonsmokers
Knott, V., Shah, D. K., Fisher, D. J., Millar, A., Prise, S., Scott, T. L., & Thompson, M. J. (2009) · Clinical EEG and Neuroscience · doi:10.1177/155005940904000108 · Cited by 21 · see citing works
Spatial and sustained attention in relation to smoking status: behavioural performance and brain activation patterns
Vossel, S., Warbrick, T., Mobascher, A., Winterer, G., & Fink, G. R. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110391830 · Cited by 18 · see citing works
Self-citation
Nicotinergic Modulation of Attention-Related Neural Activity Differentiates Polymorphisms of DRD2 and CHRNA4 Receptor Genes
Breckel, T. P. K., Gießing, C., Gieseler, A., Querbach, S., Reuter, M., & Thiel, C. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126460 · Cited by 20 · see citing works
Self-citation
Cholinergic modulation of sensory perception and plasticity
Kunnath, A. J., Gifford, R. H., & Wallace, M. T. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105323 · Cited by 19 · see citing works
The effect of nicotine on visuospatial attention in chronic spatial neglect depends upon lesion location
Vossel, S., Kukolja, J., Thimm, M., Thiel, C. M., & Fink, G. R. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109105397 · Cited by 19 · see citing works
Self-citation
Genetic variation in nicotinic receptors affects brain networks involved in reorienting attention
Gießing, C., Neber, T., & Thiel, C. M. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.061 · Cited by 19 · see citing works
Self-citation
Nicotine reduces distraction under low perceptual load
Behler, O., Breckel, T. P. K., & Thiel, C. M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3761-5 · Cited by 19 · see citing works
Self-citation
The effect of the augmentation of cholinergic neurotransmission by nicotine on EEG indices of visuospatial attention
Logemann, H. N. A., Böcker, K. B. E., Deschamps, P. K. H., Kemner, C., & Kenemans, J. L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.044 · Cited by 18 · see citing works
Response inhibition and sustained and attention in Heavy smokers versus non-smokers.
Dinur, L. K., Kertzman, S., Rosenberg, O., Kotler, M., Zangen, A., & Dannon, P. N. (2014) · PubMed · Cited by 17 · see citing works
Posterior parietal cortex dynamically ranks topographic signals via cholinergic influence
Broussard, J. I. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00032 · Cited by 16 · see citing works
Altered spontaneous activity of posterior cingulate cortex and superior temporal gyrus are associated with a smoking cessation treatment outcome using varenicline revealed by regional homogeneity
Wang, C., Shen, Z., Huang, P., Qian, W. P., Yu, X., Sun, J., Yu, H., Yang, Y., & Zhang, M. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9538-1 · Cited by 15 · see citing works
Cholinergic modulation of hippocampally mediated attention and perception.
Ruiz, N. A., Thieu, M. K., & Aly, M. (2020) · Behavioral Neuroscience · doi:10.1037/bne0000405 · Cited by 12 · see citing works
The effect of enhancing cholinergic neurotransmission by nicotine on EEG indices of inhibition in the human brain
Logemann, H. N. A., Böcker, K. B. E., Deschamps, P. K. H., Kemner, C., & Kenemans, J. L. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.03.019 · Cited by 13 · see citing works
Therapeutic Applications of Nicotinic Stimulation: Successes, Failures, and Future Prospects
NEWHOUSE, P. A. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty189 · Cited by 11 · see citing works
Differences between nicotine-abstinent smokers and non-smokers in terms of visuospatial attention and inhibition before and after single-blind nicotine administration
Logemann, H. N. A., Böcker, K. B. E., Deschamps, P. K. H., Kemner, C., & Kenemans, J. L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.016 · Cited by 11 · see citing works
Sex differences in hemispheric lateralization of attentional networks
Li, Y., Wang, Y. Y., Xiao-hong, J., Niu, D., Zhang, L., Jiang, S. Y., Ruan, H. D., & Ho, G. W. (2020) · Psychological Research · doi:10.1007/s00426-020-01423-z · Cited by 9 · see citing works
The effect of attenuating noradrenergic neurotransmission by clonidine on brain activity measures of visuospatial attention
Logemann, H. N. A., Böcker, K. B. E., Deschamps, P. K. H., Kemner, C., & Kenemans, J. L. (2013) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2367 · Cited by 10 · see citing works
Nicotine effects on attentional reorienting in mid-age adults, and interactions with apolipoprotein E status
Evans, S., Dowell, N. G., Tabet, N., Tofts, P. S., King, S. L., Gray, M. A., & Rusted, J. M. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113499828 · Cited by 10 · see citing works
Auditory orienting and inhibition of return in schizophrenia: A functional magnetic resonance imaging study
Abbott, C., Merideth, F. L., Ruhl, D. A., Yang, Z., Clark, V. P., Calhoun, V. D., Hanlon, F. M., & Mayer, A. R. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.011 · Cited by 10 · see citing works
Cholinergic potentiation of visual perception and vision restoration in rodents and humans
Vaucher, E., Laliberté, G., Higgins, M.-C., Maheux, M., Jolicœur, P., & Chamoun, M. (2019) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-190947 · Cited by 10 · see citing works
Nicotine differentially modulates antisaccade eye-gaze away from emotional stimuli in nonsmokers stratified by pre-task baseline performance
Wachter, N. J., & Gilbert, D. G. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2842-6 · Cited by 10 · see citing works
Effects of Pro-Cholinergic Treatment in Patients Suffering from Spatial Neglect
Lucas, N., Saj̈, A., Schwartz, S., Ptak, R., Schnider, A., Thomas, C., Conne, P., Leroy, R., Pavin, S., Diserens, K., et al. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00574 · Cited by 10 · see citing works
Neuropharmakologische funktionelle Bildgebung
Thiel, C. M., & Fink, G. R. (2007) · Springer eBooks · doi:10.1007/978-3-540-68558-6_11 · Cited by 9 · see citing works
Self-citation
Cognitive Effects of Nicotine
Sofuoglu, M., Herman, A. I., Robinson, C. D., & Waters, A. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418679-8.00012-5 · Cited by 8 · see citing works
Focal acetylcholinergic modulation of the human midcingulo‐insular network during attention: Meta‐analytic neuroimaging and behavioral evidence
Chakraborty, S., Lee, S. K., Arnold, S. M., Haast, R. A. M., KHAN, A. R., & Schmitz, T. W. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15990 · Cited by 8 · see citing works
Nicotine and Cognition
Beer, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00027-4 · Cited by 7 · see citing works
Moderation of nicotine effects on covert orienting of attention tasks by poor placebo performance and cue validity
Hammersley, J. J., Gilbert, D. G., Rzetelny, A., & Rabinovich, N. E. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.07.006 · Cited by 6 · see citing works
Temperament and probabilistic predictive coding in visual-spatial attention
Lasaponara, S., Scozia, G., Lozito, S., Pinto, M., Conversi, D., Costanzi, M., Vriens, T., Silvetti, M., & Doricchi, F. (2023) · Cortex · doi:10.1016/j.cortex.2023.10.004 · Cited by 5 · see citing works
Effects of Nicotine on Task Switching and Distraction in Non-smokers. An fMRI Study
Ahrens, S., & Thiel, C. M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.029 · Cited by 5 · see citing works
Self-citation
Systematic review: Effects of cholinergic signaling on cognition in human pharmacological studies
Dan, Y. R., Christakou, A., & Roelofs, K. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106408 · Cited by 5 · see citing works
The oculomotor signature of expected surprise
Drążyk, D., & Missal, M. (2021) · Scientific Reports · doi:10.1038/s41598-022-06403-4 · Cited by 4 · see citing works
Application of Functional Neuroimaging to Examination of Nicotine Dependence
David, S. P., Sweet, L. H., Cohen, R. A., MacKillop, J. M., Mulligan, R. C., & NIAURA, R. S. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6373-4_9 · Cited by 3 · see citing works
Computational Models of Neuromodulation
Yu, A. J. (2014) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-4614-7320-6_625-1 · Cited by 2 · see citing works
APOE genotype influences P3b amplitude and response to smoking abstinence in young adults
Coppens, R. P., Rabinovich, N. E., Kanneganti, R., Diggs, H. A., Wiggs, K. A., Healey, T. L., Huggenvik, J. I., Rose, G. M., & Gilbert, D. G. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05763-5 · Cited by 1 · see citing works
Neuropharmakologische funktionelle Bildgebung
Thiel, C. M., & Fink, G. R. (2013) · Springer eBooks · doi:10.1007/978-3-642-29800-4_12 · Cited by 1 · see citing works
Self-citation
Effects of substance misuse on inhibitory control in patients with attention‐deficit/hyperactivity disorder
Paraskevopoulou, M. D., van Rooij, D., Schene, A. H., Chauvin, R. J., Buitelaar, J. K., & Schellekens, A. (2021) · Addiction Biology · doi:10.1111/adb.13063 · Cited by 2 · see citing works
Computational Models of Neuromodulation
Yu, A. J. (2015) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-4614-6675-8_625 · Cited by 1 · see citing works
The effect of transcranial direct current stimulation over the dorsolateral prefrontal cortex on behavioral and brain activity indices of visuospatial attention in intrinsic reward contextsPreprint
Akıl, A. M., Cserjési, R., Németh, D., Nagy, T., Demetrovics, Z., & Logemann, H. N. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.01.551490 · Cited by 1 · see citing works
Applications of MRI to Psychopharmacology
Stein, D. J., Yang, Y., & Salmeron, B. J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-0345-7_33
Interactions between Prefrontal Cholinergic and Glutamatergic Signaling Support Attentional Function.
Howe, W. M. (2012) · Deep Blue (University of Michigan)
Modulation der Aufmerksamkeit durch Interaktion von Rauchen und genetischen Varianten nikotinischer Acetylcholinrezeptoren
Tuschy, L. (2013) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-13213
Effects of cholinesterase inhibition on brain function
Bentley, P. (2011) · UCL Discovery (University College London)
Von der Grundlagenforschung zum klinischen Einsatz in Diagnostik und Therapie
Fink, G. R., & Schneider, F. W. (2013) · Springer eBooks · doi:10.1007/978-3-642-29800-4_4
Self-citation
Neural and cognitive determinants of smoking addiction and cessation
Havermans, A. (2016) · doi:10.26481/dis.20160513ah
Cholinergic and Anatomical Dissociation of the Engagement and Disengagement of Spatial Attention in Rats
Ljubojevic, V. (2015) · TSpace (University of Toronto)
Functional Magnetic Resonance Imaging of Acute Nicotine Effects
Thiel, C. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813035-3.00016-2
Self-citation
Vision Augmentation by Pharmacological Enhancement of the Visual Experience
Vaucher, E. (2021) · Contemporary clinical neuroscience · doi:10.1007/978-3-030-54564-2_28
Applications of MRI to Psychopharmacology
Stein, D. J., Yang, Y., & Salmeron, B. J. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1995-6_19
Computational Models of Neuromodulation
Yu, A. J. (2022) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-0716-1006-0_625
Applications of MRI to Psychopharmacology
Stein, D. J., Yang, Y., & Salmeron, B. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-10909-6_37
The effect of transcranial direct current stimulation on frontal alpha asymmetry and visuospatial attention in food-reward contexts: a triple-blind randomized sham-controlled study
Akıl, A. M., Cserjési, R., Németh, D., Nagy, T., Demetrovics, Z., & Logemann, H. N. A. (2025) · BMC Psychology · doi:10.1186/s40359-025-02972-x · Cited by 1 · see citing works
The Effects of Self-regarding and Others-regarding Rewards on Creativity: Behavioral and Neurological EvidencePreprint
Presslee, A., Tang, H., & Yang, X. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5395211
The role of the endocannabinoid system in attention and nicotine addiction
van Klinken, W. P. (2011) · Utrecht University Repository (Utrecht University)
Associations between subjective cognitive concern, brain network connectivity, and cognitive performance in cognitively normal older adults
Albert, K., Boyd, B., McDonald, B. C., Dumas, J., Saykin, A. J., Taylor, W., & Newhouse, P. (2025) · Aging Brain · doi:10.1016/j.nbas.2025.100155
Treatment of Attention Disorders
Bartolomeo, P. (2013) · Springer eBooks · doi:10.1007/978-1-4471-5649-9_9

Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects
Vossel, S., Thiel, C. M., & Fink, G. R. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301469 · Cited by 81 · see citing works
Self-citation
Nicotine modulates reorienting of visuospatial attention and neural activity in human parietal cortex
Thiel, C. M., Zilles, K., & Fink, G. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300633 · Cited by 182 · see citing works
Self-citation
The modulatory effects of nicotine on parietal cortex activity in a cued target detection task depend on cue reliability
Giessing, C., Thiel, C. M., Rösler, F., & Fink, G. R. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.005 · Cited by 104 · see citing works
Self-citation
Cholinergic modulation of covert attention in the rat
Stewart, C., Burke, S., & Marrocco, R. T. (2001) · Psychopharmacology · doi:10.1007/s002130100692 · Cited by 47 · see citing works
The effect of nicotine on visuospatial attention in chronic spatial neglect depends upon lesion location
Vossel, S., Kukolja, J., Thimm, M., Thiel, C. M., & Fink, G. R. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109105397 · Cited by 19 · see citing works
Self-citation

Authors: Thiel, C. M., & Fink, G. R.
Affiliations: Carl von Ossietzky Universität Oldenburg (DE)
Forschungszentrum Jülich (DE)
Corresponding author: Thiel, C.M.
ORCID: Thiel, C.M.
Fink, G.R.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2008-03
Volume: 152
Issue: 2
Pages: 381-390
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2007.10.061
OpenAlex: W2044846783
Cited by: 97
References: 55
Citations by year: 2025: 5 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 12 · 2013: 11 · 2012: 9
FWCI: 3.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (KFO-112)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: nicotine, nicotinic acetylcholine receptors, attentional reorienting, top-down attentional control, visuospatial attention, inferior parietal cortex, middle temporal gyrus, middle frontal gyrus, parahippocampal gyrus, cerebellum, occipital cortex, attentional modulation
MeSH terms: Adult, Analysis of Variance, Attention, Brain, Brain Mapping, Cues, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Nicotine, Oxygen, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Space Perception, Visual Fields, Nicotinic Agonists

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Effects of the cholinergic agonist nicotine on reorienting of visual spatial attention and top-down attentional control

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