fMRI Data Predict Individual Differences of Behavioral Effects of Nicotine: A Partial Least Square Analysis
Abstract
Reorienting of visuospatial attention can be investigated by comparing reaction times to validly and invalidly cued targets (“validity effect”). The cholinergic agonist nicotine reduces the validity effect and neural activity in the posterior parietal cortex. Behavioral effects of nicotine in nonsmokers are weak and it has been suggested that differences in baseline behavior before nicotine exposure may influence the effect of nicotine. This study investigates whether individual differences in reorienting-related neural activity under placebo may be used to predict individual nicotine effects. Individual nicotine effects are defined as the behavioral effects under nicotine that cannot be predicted by the behavioral data under placebo. Fifteen nonsmoking subjects were given either placebo or nicotine gum (2 mg) prior to performing a cued target detection task inside a magnetic resonance imaging scanner. The results of a partial least square analysis suggest that neural data under placebo can be used to predict individual behavioral effects of nicotine. Neural activity in the left posterior cingulate cortex, the right superior parietal cortex, the right dorsal medial prefrontal cortex, and the left ventral medial prefrontal cortex significantly contributes to that prediction. We conclude that nicotine effects on reorienting attention depend on individual differences in reorienting-related neural activity under placebo and suggest that functional magnetic resonance imaging data can contribute to the prediction of individual drug effects.
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Individual differences in performance-associated activity in prefrontal and parietal regions predict performance effects of nicotine.
“Additional analyses indicated that individual differences in performance-associated activity in prefrontal and parietal regions predict performance effects of nicotine (Giessing et al, 2007).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Giessing et al, 2007
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- Authors
- Giessing, C., Fink, G. R., Rösler, F., & Thiel, C. M.
- Affiliations
- Forschungszentrum Jülich (DE)
- Philipps University of Marburg (DE)
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press - Journals
- Published
- 2007-04-01
- Volume
- 19
- Issue
- 4
- Pages
- 658-670
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W1980070382
- Cited by
- 51
- References
- 88
- Citations by year
- 2021: 3 · 2020: 1 · 2017: 3 · 2016: 2 · 2014: 2 · 2013: 7 · 2012: 4
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine, individual differences, attentional reorienting, visuospatial attention, validity effect, posterior parietal cortex, posterior cingulate cortex, medial prefrontal cortex, non-smokers, cholinergic agonists
- MeSH terms
- Adult, Attention, Brain Mapping, Female, Ganglionic Stimulants, Humans, Individuality, Functional Laterality, Magnetic Resonance Imaging, Male, Models, Neurological, Nicotine, Orientation, Parietal Lobe, Predictive Value of Tests, Reference Values, Space Perception, Least-Squares Analysis, Nicotinic Agonists
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