Characterization of fear memory reconsolidation
Open accessAbstract
Reactivation of consolidated memories returns them to a protein synthesis-dependent state. One interpretation of these findings is that the memory reconsolidates after use. Two alternative interpretations are that protein synthesis inhibition facilitates extinction and that postreactivation protein synthesis inhibition leads to an inability to retrieve the consolidated memory. First, using two different approaches, we report that reconsolidation cannot be reduced down to facilitated extinction. We show that the reconsolidation deficit does not show renewal after a contextual shift, whereas an extinguished auditory fear memory does under the same conditions and the deficit occurs regardless of whether the memory is reactivated with an extinction [conditioned stimulus (CS) alone] or a reinforced trial (CS-unconditioned stimulus). To address the issue of whether postreactivation anisomycin leads to an inability to retrieve the consolidated memory, we used two traditional assays for retrieval deficits. First, we demonstrate that the amnesia induced by blockade of reconsolidation does not show any spontaneous recovery. Second, we show that application of reminder shock does not result in the reinstatement of the memory. These findings support the idea that reactivation of consolidated memories initiates a second time-dependent memory formation process.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neuroscience has shown that re-accessing memories generally changes them, rather than enforces them.
“Indeed, neuroscience has shown that re-accessing memories generally changes them, rather than enforces them.66,67”
From The overfitted brain: Dreams evolved to assist generalization (2021) · cites this paper as [66]
The Introduction (page not specified) says reactivating a consolidated auditory fear memory makes it labile and requires reconsolidation to restabilize the original memory. The Abstract likewise describes a second memory-formation process after reactivation. Neither passage shows that re-accessing memories generally changes them rather than reinforces them; the paper addresses a specific fear-memory process. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706 · see citing works
Self-citationNeurobiology of Pavlovian Fear Conditioning
Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,805 · see citing works
The Neurobiology of Consolidations, Or, How Stable is the Engram?
Dudai, Y. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142050 · Cited by 1,671 · see citing works
McGaugh, J. L. (1966) · Science · doi:10.1126/science.153.3742.1351 · Cited by 1,468 · see citing works
Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures
Suzuki, A., Josselyn, S. A., Frankland, P. W., Masushige, S., Silva, A. J., & Kida, S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5491-03.2004 · Cited by 1,127 · see citing works
Dissociable stages of human memory consolidation and reconsolidation
Walker, M. P., Brakefield, T., Allan Hobson, J., & Stickgold, R. (2003) · Nature · doi:10.1038/nature01930 · Cited by 1,025 · see citing works
Retrieval and reconsolidation: Toward a neurobiology of remembering
Sara, S. J. (2000) · Learning & Memory · doi:10.1101/lm.7.2.73 · Cited by 919 · see citing works
Contextual control of the extinction of conditioned fear
Bouton, M. E., & Bolles, R. C. (1979) · Learning and Motivation · doi:10.1016/0023-9690(79)90057-2 · Cited by 796 · see citing works
Nader, K. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00042-5 · Cited by 763 · see citing works
Self-citationCellular and Systems Reconsolidation in the Hippocampus
Dębiec, J., LeDoux, J. E., & Nader, K. (2002) · Neuron · doi:10.1016/s0896-6273(02)01001-2 · Cited by 758 · see citing works
Self-citationThe labile nature of consolidation theory
Nader, K., Schafe, G. E., & LeDoux, J. E. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044580 · Cited by 613 · see citing works
Self-citationSchafe, G. E., & LeDoux, J. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-j0003.2000 · Cited by 611 · see citing works
Stability of retrieved memory: Inverse correlation with trace dominance
Eisenberg, M., Kobilo, T., Berman, D. E., & Dudai, Y. (2003) · Science · doi:10.1126/science.1086881 · Cited by 518 · see citing works
Protein Synthesis Subserves Reconsolidation or Extinction Depending on Reminder Duration
Pedreira, M. E., & Maldonado, H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00352-0 · Cited by 406 · see citing works
Bozon, B., Davis, S., & Laroche, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00674-3 · Cited by 317 · see citing works
Vianna, M., Szapiro, G., McGaugh, J. D., Medina, J., & Izquierdo, I. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.211433298 · Cited by 301 · see citing works
Lattal, K. M., & Abel, T. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306546101 · Cited by 220 · see citing works
Fischer, A., Sananbenesi, F., Schrick, C., Spiess, J., & Radulović, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5112-03.2004 · Cited by 219 · see citing works
The neurobiology of learning and memory: some reminders to remember
Cahill, L. F., McGaugh, J. L., & Weinberger, N. M. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01885-3 · Cited by 207 · see citing works
Anokhin, K. V., Тиунова, А. А., & Rose, S. P. R. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02023.x · Cited by 207 · see citing works
Retrograde amnesia: Storage failure versus retrieval failure.
Gold, P. E., & King, R. A. (1974) · Psychological Review · doi:10.1037/h0036949 · Cited by 107 · see citing works
Maren, S., Ferrario, C. R., Corcoran, K. A., Desmond, T. J., & Frey, K. A. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03063.x · Cited by 102 · see citing works
Quartermain, D., & McEwen, B. S. (1970) · Nature · doi:10.1038/228677a0 · Cited by 83 · see citing works
Forgetting, Reminding, and Remembering: The Retrieval of Lost Spatial Memory
de Hoz, L., Martin, S. J., & Morris, R. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020225 · Cited by 75 · see citing works
Retrograde Amnesia and the "Reminder Effect": An Alternative Interpretation
Gold, P. E., Haycock, J. W., Macri, J., & McGaugh, J. L. (1973) · Science · doi:10.1126/science.180.4091.1199 · Cited by 72 · see citing works
Implications of recovery from experimental amnesia.
Miller, R. R., & Springer, A. D. (1974) · Psychological Review · doi:10.1037/h0036951 · Cited by 71 · see citing works
Retrograde amnesia in the chick: Resistance to the reminder effect
Cherkin, A. (1972) · Physiology & Behavior · doi:10.1016/0031-9384(72)90309-5 · Cited by 62 · see citing works
Acetoxycycloheximide and Transient Amnesia in the Rat
Serota, R. G. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.6.1249 · Cited by 59 · see citing works
Myers, K. M., & Davis, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01017-6 · Cited by 57 · see citing works
Recovery of a conditioned emotional response after one or two electroconvulsive shocks.
Kohlenberg, R. J., & Trabasso, T. (1968) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0025537 · Cited by 54 · see citing works
Salińska, E., Bourne, R. C., & Rose, S. P. R. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03407.x · Cited by 52 · see citing works
Hewish, A. (1980) · Nature · doi:10.1038/285095a0 · Cited by 51 · see citing works
Memory Reconsolidation inHermissenda
Child, F. M., Epstein, H. T., Kuzirian, A. M., & Alkon, D. L. (2003) · Biological Bulletin · doi:10.2307/1543261 · Cited by 49 · see citing works
Recovery as a function of the degree of amnesia due to protein synthesis inhibition
Davis, H. P., Rosenzweig, M. R., Bennett, E. L., & Orme, A. E. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90269-1 · Cited by 39 · see citing works
Recovery from ECS-produced amnesia
Young, A. G., & Galluscio, E. H. (1971) · Psychonomic Science · doi:10.3758/bf03332541 · Cited by 26 · see citing works
Somatic and autonomic indexes of recovery from electroconvulsive shock-induced amnesia in rats.
Miller, R. R., & Kraus, J. N. (1977) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077326 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Preventing the return of fear in humans using reconsolidation update mechanisms
Schiller, D., Monfils, M.-H., Raio, C. M., Johnson, D. C., LeDoux, J. E., & Phelps, E. A. (2010) · Nature · doi:10.1038/nature08637 · Cited by 1,248 · see citing works
Walker, M. P., & Stickgold, R. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070307 · Cited by 1,075 · see citing works
Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories
Monfils, M.-H., Cowansage, K. K., Klann, E., & LeDoux, J. E. (2009) · Science · doi:10.1126/science.1167975 · Cited by 960 · see citing works
A single standard for memory: The case for reconsolidation
Nader, K., & Hardt, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2590 · Cited by 811 · see citing works
Self-citationMolecular mechanisms of memory reconsolidation
Tronson, N. C., & Taylor, J. R. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2090 · Cited by 783 · see citing works
Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · see citing works
“[320]; Duvarci and Nader [321]), of the representation of the original experience by the hippocampus could produce a hypermnesic (strengthening) of the memory of”
BackgroundAn Update on Memory Reconsolidation Updating
Lee, J. L. C., Nader, K., & Schiller, D. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.04.006 · Cited by 557 · see citing works
Self-citationHippocampal-Neocortical Interactions in Memory Formation, Consolidation, and Reconsolidation
Wang, S., & Morris, R. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100523 · Cited by 536 · see citing works
Reconsolidation: maintaining memory relevance
Lee, J. L. C. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.002 · Cited by 516 · see citing works
Sleep-dependent memory consolidation and reconsolidation
Stickgold, R., & Walker, M. P. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.011 · Cited by 535 · see citing works
Changing Fear: The Neurocircuitry of Emotion Regulation
Hartley, C. A., & Phelps, E. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.121 · Cited by 492 · see citing works
Neuronal circuits of fear extinction
Herry, C., Ferraguti, F., Singewald, N., Letzkus, J. J., Ehrlich, I., & Lüthi, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07101.x · Cited by 484 · see citing works
Reconsolidation and Extinction of Conditioned Fear: Inhibition and Potentiation
Lee, J. L. C., Milton, A. L., & Everitt, B. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2466-06.2006 · Cited by 479 · see citing works
Induction of Fear Extinction with Hippocampal-Infralimbic BDNF
Peters, J., Dieppa-Perea, L. M., Melendez, L. M., & Quirk, G. J. (2010) · Science · doi:10.1126/science.1186909 · Cited by 462 · see citing works
Neural and cellular mechanisms of fear and extinction memory formation
Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429 · see citing works
Memory consolidation and reconsolidation: what is the role of sleep?
Stickgold, R., & WALKER, M. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.004 · Cited by 422 · see citing works
Memory reconsolidation mediates the strengthening of memories by additional learning
Lee, J. L. C. (2008) · Nature Neuroscience · doi:10.1038/nn.2205 · Cited by 398 · see citing works
Disrupting Reconsolidation of Drug Memories Reduces Cocaine-Seeking Behavior
Lee, J. L. C., Ciano, P. D., Thomas, K. L., & Everitt, B. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.007 · Cited by 391 · see citing works
Reconsolidation: the advantage of being refocused
Dudai, Y. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.03.010 · Cited by 357 · see citing works
Memory reconsolidation: an update
Nader, K., & Einarsson, E. Ö. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05443.x · Cited by 356 · see citing works
Self-citationConsolidation and Reconsolidation: Two Lives of Memories?
McKenzie, S., & Eichenbaum, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.037 · Cited by 338 · see citing works
Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidation
Wang, S., Alvares, L. D. O., & Nader, K. (2009) · Nature Neuroscience · doi:10.1038/nn.2350 · Cited by 305 · see citing works
Self-citationPittig, A., Treanor, M., LeBeau, R. T., & Craske, M. G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.015 · Cited by 294 · see citing works
Valjent, E., Corbillé, A.-G., Bertran‐Gonzalez, J., Hervé, D., & Girault, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511030103 · Cited by 295 · see citing works
The cognitive cost of sleep lost
McCoy, J. G., & Strecker, R. E. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.07.004 · Cited by 284 · see citing works
Mamiya, N., Fukushima, H., Suzuki, A. Z., Matsuyama, Z., Homma, S., Frankland, P. W., & Kida, S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4639-08.2009 · Cited by 276 · see citing works
Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A
Tronson, N. C., Wiseman, S. L., Olausson, P., & Taylor, J. R. (2006) · Nature Neuroscience · doi:10.1038/nn1628 · Cited by 264 · see citing works
Task and Content Modulate Amygdala-Hippocampal Connectivity in Emotional Retrieval
Smith, A. P. R., Stephan, K. E., Rugg, M. D., & Dolan, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.025 · Cited by 252 · see citing works
Reduction of PTSD symptoms with pre-reactivation propranolol therapy: A randomized controlled trial
Brunet, A., Saumier, D., Liu, A., Streiner, D. L., Tremblay, J., & Pitman, R. K. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17050481 · Cited by 256 · see citing works
Retrieval per se is not sufficient to trigger reconsolidation of human fear memory
Sevenster, D., Beckers, T., & Kindt, M. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.01.009 · Cited by 238 · see citing works
Akirav, I., & Maroun, M. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj114 · Cited by 240 · see citing works
The IκB Kinase Regulates Chromatin Structure during Reconsolidation of Conditioned Fear Memories
Lubin, F. D., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.039 · Cited by 234 · see citing works
Makkar, S., Zhang, S., & Cranney, J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.53 · Cited by 232 · see citing works
Persistent Disruption of an Established Morphine Conditioned Place Preference
Milekic, M. H., Brown, S. D., Castellini, C., & Alberini, C. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4818-05.2006 · Cited by 214 · see citing works
Deębiec, J., Doyère, V., Nader, K., & LeDoux, J. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507168103 · Cited by 207 · see citing works
Self-citationUpdating memories—The role of prediction errors in memory reconsolidation
Exton-McGuinness, M. T. J., Lee, J. L. C., & Reichelt, A. C. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.011 · Cited by 202 · see citing works
Challenges in Developing Novel Treatments for Childhood Disorders: Lessons from Research on Anxiety
Pine, D. S., Helfinstein, S. M., Bar-Haim, Y., Nelson, E., & Fox, N. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.113 · Cited by 194 · see citing works
Reconsolidation of declarative memory in humans
Forcato, C., Burgos, V. L., Argibay, P. F., Molina, V. A., Pedreira, M. E., & Maldonado, H. (2007) · Learning & Memory · doi:10.1101/lm.486107 · Cited by 229 · see citing works
Salinas-Hernández, X. I., Vogel, P., Betz, S., Kalisch, R., Sigurdsson, T., & Duvarci, S. (2018) · eLife · doi:10.7554/elife.38818 · Cited by 181 · see citing works
Self-citationThe role of protein synthesis during the labile phases of memory: Revisiting the skepticism
Alberini, C. M. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.007 · Cited by 178 · see citing works
The fate of memory: Reconsolidation and the case of Prediction Error
Fernández, R. S., Boccia, M. M., & Pedreira, M. E. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.004 · Cited by 173 · see citing works
The computational nature of memory modification
Gershman, S. J., Monfils, M.-H., Norman, K. A., & Niv, Y. (2017) · eLife · doi:10.7554/elife.23763 · Cited by 172 · see citing works
Bustos, S. G., Maldonado, H., & Molina, V. A. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.75 · Cited by 168 · see citing works
Detection of a Temporal Error Triggers Reconsolidation of Amygdala-Dependent Memories
Díaz-Mataix, L., Martinez, R. C. R., Schafe, G. E., LeDoux, J. E., & Doyère, V. (2013) · Current Biology · doi:10.1016/j.cub.2013.01.053 · Cited by 168 · see citing works
Reconsolidation of memory: A decade of debate
Besnard, A., Caboche, J., & Laroche, S. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.07.002 · Cited by 168 · see citing works
Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation
Blundell, J., Kouser, M., & Powell, C. M. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.12.004 · Cited by 162 · see citing works
Power, A. E., Berlau, D. J., McGaugh, J. L., & Steward, O. (2006) · Learning & Memory · doi:10.1101/lm.91206 · Cited by 159 · see citing works
On disruption of fear memory by reconsolidation blockade: evidence from cannabidiol treatment
Stern, C. A. J., Gazarini, L., Takahashi, R. N., Guimarães, F. S., & Bertoglio, L. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.63 · Cited by 156 · see citing works
Forcato, C., Argibay, P. F., Pedreira, M. E., & Maldonado, H. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.09.011 · Cited by 154 · see citing works
Monfils, M., & Holmes, E. A. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30270-0 · Cited by 144 · see citing works
Does Reconsolidation Occur in Humans?
Schiller, D., & Phelps, E. A. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00024 · Cited by 211 · see citing works
Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction
de Oliveira Alvares, L., Pasqualini Genro, B., Diehl, F., Molina, V. A., & Quillfeldt, J. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.005 · Cited by 143 · see citing works
Roles of the Endocannabinoid System in Learning and Memory
Marsicano, G., & Lafenêtre, P. (2009) · Current topics in behavioral neurosciences · doi:10.1007/978-3-540-88955-7_8 · Cited by 140 · see citing works
Maddox, S. A., & Schafe, G. E. (2011) · Learning & Memory · doi:10.1101/lm.2243411 · Cited by 130 · see citing works
Abrari, K., Rashidy‐Pour, A., Semnanian, S., & Fathollahi, Y. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.07.005 · Cited by 126 · see citing works
Oyarzún, J. P., Lopez-Barroso, D., Fuentemilla, L., Cucurell, D., Pedraza, C., Rodriguez-Fornells, A., & de Diego-Balaguer, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038849 · Cited by 125 · see citing works
Midazolam disrupts fear memory reconsolidation
Bustos, S. G., Maldonado, H., & Molina, V. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.064 · Cited by 122 · see citing works
Brain sites involved in fear memory reconsolidation and extinction of rodents
Baldi, E., & Bucherelli, C. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.003 · Cited by 116 · see citing works
Reconsolidation of drug memories
Sorg, B. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.004 · Cited by 118 · see citing works
Reconsolidation: A brief history, a retrieval view, and some recent issuesPreprint
Riccio, D. C., Millin, P. M., & Bogart, A. R. (2006) · Learning & Memory · doi:10.1101/lm.290706 · Cited by 115 · see citing works
Rodríguez‐Ortiz, C. J., la Cruz, V. D., Gutiérrez, R., & Bermúdez‐Rattoni, F. (2005) · Learning & Memory · doi:10.1101/lm.94505 · Cited by 117 · see citing works
In memory of consolidationPreprint
Sara, S. J., & Hars, B. (2006) · Learning & Memory · doi:10.1101/lm.338406 · Cited by 114 · see citing works
Mao, S.-C., Hsiao, Y., & Gean, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0365-06.2006 · Cited by 112 · see citing works
Costanzi, M., Cannas, S., Saraulli, D., Rossi‐Arnaud, C., & Cestari, V. (2011) · Learning & Memory · doi:10.1101/lm.2175811 · Cited by 111 · see citing works
Fricks‐Gleason, A. N., & Marshall, J. F. (2008) · Learning & Memory · doi:10.1101/lm.1054608 · Cited by 111 · see citing works
Tronel, S., & Alberini, C. M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.009 · Cited by 110 · see citing works
Epigenetic mechanisms of memory formation and reconsolidation
Jarome, T. J., & Lubin, F. D. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.002 · Cited by 112 · see citing works
Lin, H.-C., Mao, S.-C., & Gean, P.-W. (2006) · Learning & Memory · doi:10.1101/lm.217006 · Cited by 107 · see citing works
Sacchetti, B., Sacco, T., & Strata, P. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05508.x · Cited by 105 · see citing works
Coccoz, V., Maldonado, H., & Delorenzi, A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.023 · Cited by 103 · see citing works
Apergis-Schoute, A. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0096-05.2005 · Cited by 101 · see citing works
Resstel, L. B. M., Corrêa, F. M. D. A., & Guimarães, F. S. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm232 · Cited by 96 · see citing works
Hellemans, K. G. C., Everitt, B. J., & Lee, J. L. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3101-06.2006 · Cited by 93 · see citing works
Maddox, S. A., Watts, C. S., & Schafe, G. E. (2013) · Learning & Memory · doi:10.1101/lm.029157.112 · Cited by 95 · see citing works
Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder
Pinna, G., & Rasmusson, A. M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00256 · Cited by 94 · see citing works
Anisomycin and the reconsolidation hypothesisPreprint
Rudy, J. W., Biedenkapp, J. C., Moineau, J., & Bolding, K. A. (2006) · Learning & Memory · doi:10.1101/lm.157806 · Cited by 92 · see citing works
Repeated Labilization-Reconsolidation Processes Strengthen Declarative Memory in Humans
Forcato, C., Rodríguez, M. L. C., & Pedreira, M. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023305 · Cited by 90 · see citing works
Kranjac, D., McLinden, K. A., Deodati, L. E., Papini, M. R., Chumley, M. J., & Boehm, G. W. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.08.005 · Cited by 88 · see citing works
Fear Processing, Psychophysiology, and PTSD
Norrholm, S. D., & Jovanović, T. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000189 · Cited by 85 · see citing works
β-adrenoceptor mediated inhibition of long-term reward-related memory reconsolidation
Diergaarde, L., Schoffelmeer, A. N. M., & Vries, T. J. D. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.02.014 · Cited by 86 · see citing works
Pitman, R. K., Milad, M. R., Igoe, S. A., Vangel, M. G., Orr, S. P., Tsareva, A., Gamache, K., & Nader, K. (2011) · Behavioral Neuroscience · doi:10.1037/a0024364 · Cited by 84 · see citing works
Self-citationMeyer, F., & Louilot, A. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00118 · Cited by 84 · see citing works
Addiction: a drug-induced disorder of memory reconsolidation
Tronson, N. C., & Taylor, J. R. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.022 · Cited by 83 · see citing works
Postretrieval new learning does not reliably induce human memory updating via reconsolidation
Hardwicke, T. E., Taqi, M., & Shanks, D. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601440113 · Cited by 83 · see citing works
Steinfurth, E. C. K., Kanen, J. W., Raio, C. M., Clem, R. L., Huganir, R. L., & Phelps, E. A. (2014) · Learning & Memory · doi:10.1101/lm.033589.113 · Cited by 82 · see citing works
Covert capture and attenuation of a hippocampus-dependent fear memory
Ressler, R. L., Goode, T. D., Kim, S., Ramanathan, K. R., & Maren, S. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00825-5 · Cited by 82 · see citing works
Behavioral Methods to Study Learning and Memory in Rats
Quillfeldt, J. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-11578-8_17 · Cited by 81 · see citing works
Stern, C. A. J., Gazarini, L., Vanvossen, A. C., Zuardi, A. W., Galve‐Roperh, I., Guimarães, F. S., Takahashi, R. N., & Bertoglio, L. J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.02.001 · Cited by 78 · see citing works
Li, Q., Luo, T., Jiang, X. X., & Wang, J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.002 · Cited by 78 · see citing works
von der Goltz, C., Vengeliene, V., Bilbao, A., Perreau‐Lenz, S., Pawlak, C. R., Kiefer, F., & Spanagel, R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1544-1 · Cited by 76 · see citing works
Ramirez, D. R., Bell, G. H., Lasseter, H. C., Xie, X., Traina, S. A., & Fuchs, R. A. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06889.x · Cited by 77 · see citing works
Milekic, M. H., Pollonini, G., & Alberini, C. M. (2007) · Learning & Memory · doi:10.1101/lm.598307 · Cited by 77 · see citing works
Arshavsky, Y. I. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.09.004 · Cited by 74 · see citing works
Lattal, K. M., Radulović, J., & Lukowiak, K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.038 · Cited by 74 · see citing works
Retrieval failure versus memory loss in experimental amnesia: Definitions and processesPreprint
Miller, R. R., & Matzel, L. D. (2006) · Learning & Memory · doi:10.1101/lm.241006 · Cited by 73 · see citing works
A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory
Ren, Z.-Y., Liu, M.-M., Xue, Y.-X., Ding, Z.-B., Xue, L.-F., Zhai, S.-D., & Lu, L. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.243 · Cited by 73 · see citing works
Diergaarde, L., Schoffelmeer, A. N. M., & Vries, T. J. D. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.010 · Cited by 72 · see citing works
Yamada, D., Zushida, K., Wada, K., & Sekiguchi, M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.86 · Cited by 72 · see citing works
Taubenfeld, S. M., Riceberg, J. S., New, A. S., & Alberini, C. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.005 · Cited by 71 · see citing works
The overfitted brain: Dreams evolved to assist generalization
Hoel, E. (2021) · Patterns · doi:10.1016/j.patter.2021.100244 · Cited by 70 · see citing works
“Indeed, neuroscience has shown that re-accessing memories generally changes them, rather than enforces them (Duvarci and Nader, 2004).”
Background
- Authors
- Duvarci, S., & Nader, K.
- Affiliations
- W. M. Keck Foundation (US)
- McGill University (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-10-20
- Volume
- 24
- Issue
- 42
- Pages
- 9269-9275
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6730081
- OpenAlex
- W2018795098
- Cited by
- 379
- References
- 39
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 13 · 2022: 18 · 2021: 15 · 2020: 14 · 2019: 14 · 2018: 16 · 2017: 22 · 2016: 18 · 2015: 24 · 2014: 23 · 2013: 21 · 2012: 24
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alfred P. Sloan Foundation
- Volkswagen Foundation
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- fear memory reconsolidation, memory reactivation, protein synthesis inhibition, anisomycin, extinction, memory retrieval, memory consolidation, spontaneous recovery, reinstatement, auditory fear conditioning
- MeSH terms
- Amygdala, Animals, Anisomycin, Conditioning, Psychological, Extinction, Psychological, Fear, Male, Memory, Protein Synthesis Inhibitors, Time Factors, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
