Cited by 52Neuroscience and Music PerceptionTactile and Sensory InteractionsAnimal Vocal Communication and Behavior

Dissecting natural sensory plasticity: hormones and experience in a maternal context

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Miranda, Jason A., Liu, Robert C.·2009·Hearing Research

Abstract

There is a growing consensus that the auditory system is dynamic in its representation of behaviorally relevant sounds. The auditory cortex in particular seems to be an important locus for plasticity that may reflect the memory of such sounds, or functionally improve their processing. The mechanisms that underlie these changes may be either intrinsic because they depend on the receiver's physiological state, or extrinsic because they arise from the context in which behavioral relevance is gained. Research in a mouse model of acoustic communication between offspring and adult females offers the opportunity to explore both of these contributions to auditory cortical plasticity in a natural context. Recent works have found that after the vocalizations of infant mice become behaviorally relevant to mothers, auditory cortical activity is significantly changed in a way that may improve their processing. Here we consider the hypothesis that maternal hormones (intrinsic factor) and sensory experience (extrinsic factor) contribute together to drive these changes, focusing specifically on the evidence that well-known experience-dependent mechanisms of cortical plasticity can be modulated by hormones.

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Crossref · 10.1016/j.heares.2009.04.014

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  1. Rosenblatt JS Siegel HI Gubernick DJ Klopfer PH 1981 Factors governing the onset and maintenance of maternal behavior among nonprimate mammals: The role of hormonal and nonhormonal factors Parental care in mammals Plenum Press New York 13 76

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Authors
Miranda, J. A., & Liu, R. C.
Affiliations
Emory University (US)
Corresponding author
Miranda, Jason A.
Venue
Hearing Research
Publisher
Elsevier BV
Published
2009-06
Volume
252
Issue
1-2
Pages
21-28
ISSN
0378-5955 (ISSN-L)
OpenAlex
W2022705038
Cited by
52
References
118
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 7 · 2012: 8
FWCI
2.23
Type
journal article
Language
en
Open access
Locations
  • Hearing Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Deafness and Other Communication Disorders (DC-008343, R01DC008343)
  • National Institute of General Medical Sciences (K12GM000680)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Animal Vocal Communication and Behavior
Keywords
maternal hormones, sensory experience, infant vocalizations, experience-dependent plasticity, auditory cortex, mouse model, maternal behavior
MeSH terms
Acetylcholine, Animals, Auditory Cortex, Dopamine, Estradiol, Female, Models, Neurological, Neuronal Plasticity, Norepinephrine, Pregnancy, Progesterone, Serotonin, Vocalization, Animal, Mice

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