Cited by 115Memory and Neural MechanismsStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

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Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction

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Wilber, A.A., Walker, A.G., Southwood, C.J., Farrell, M.R., Lin, G.L., Rebec, G.V., Wellman, C.L.·2011·Neuroscience

DOI 10.1016/j.neuroscience.2010.10.070PMC PMC3020264

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Abstract

Chronic restraint stress produces morphological changes in medial prefrontal cortex and disrupts a prefrontally mediated behavior, retrieval of extinction. To assess potential physiological correlates of these alterations, we compared neural activity in infralimbic and prelimbic cortex of unstressed versus stressed rats during fear conditioning and extinction. After implantation of microwire bundles into infralimbic or prelimbic cortex, rats were either unstressed or stressed via placement in a plastic restrainer (3 h/day for 1 week). Rats then underwent fear conditioning and extinction while activity of neurons in infralimbic or prelimbic cortex was recorded. Percent freezing and neural activity were assessed during all phases of training. Chronic stress enhanced freezing during acquisition of conditioned fear, and altered both prelimbic and infralimbic activity during this phase. Stress did not alter initial extinction or conditioned stimulus (CS)-related activity during this phase. However, stress impaired retrieval of extinction assessed 24 h later, and this was accompanied by alterations in neuronal activity in both prelimbic and infralimbic cortex. In prelimbic cortex, unstressed rats showed decreased activity in response to CS presentation, whereas stressed rats showed no change. In infralimbic cortex, neurons in unstressed rats exhibited increased firing in response to the CS, whereas stressed rats showed no increase in infralimbic firing during the tone. Finally, CS-related firing in infralimbic but not prelimbic cortex was correlated with extinction retrieval. Thus, the stress-induced alteration of neuronal activity in infralimbic cortex may be responsible for the stress-induced deficit in retrieval of extinction.

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Chronic Stress Effects on Corticolimbic Morphology
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Self-citation

Authors: Wilber, A. A., Walker, A. G., Southwood, C. J., Farrell, M. R., Lin, G. L., Rebec, G. V., & Wellman, C. L.
Affiliations: Indiana University Bloomington (US)
Corresponding author: Wellman, C.L.
ORCID: Wilber, A.A.
Lin, G.L.
Rebec, G.V.
Wellman, C.L.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2011-02
Volume: 174
Pages: 115-131
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2010.10.070
PMC: PMC3020264
OpenAlex: W2039543325
Semantic Scholar: ec3c2ff6cfebae04751b5903c47df5b3116789fa
Cited by: 115
References: 59
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 12 · 2018: 10 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 11 · 2013: 14 · 2012: 10
FWCI: 5.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service (MHR03087794)
National Institute of Mental Health (F31MH085415, R03MH087794)
National Institute of Neurological Disorders and Stroke (F31NS066603, F31NS064791)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: chronic restraint stress, medial prefrontal cortex, infralimbic cortex, prelimbic cortex, extinction retrieval, fear extinction, fear conditioning, neuronal firing, conditioned stimulus, neuronal activity
MeSH terms: Action Potentials, Animals, Conditioning, Operant, Extinction, Psychological, Fear, Male, Neurons, Restraint, Physical, Stress, Psychological, Rats, Sprague-Dawley, Prefrontal Cortex, Rats

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Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction

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