Alterations in neuronal morphology in infralimbic cortex predict resistance to fear extinction following acute stress
Open accessAbstract
Dysfunction in corticolimbic circuits that mediate the extinction of learned fear responses is thought to underlie the perseveration of fear in stress-related psychopathologies, including post-traumatic stress disorder. Chronic stress produces dendritic hypertrophy in basolateral amygdala (BLA) and dendritic hypotrophy in medial prefrontal cortex, whereas acute stress leads to hypotrophy in both BLA and prelimbic cortex. Additionally, both chronic and acute stress impair extinction retrieval. Here, we examined the effects of a single elevated platform stress on extinction learning and dendritic morphology in infralimbic cortex, a region considered to be critical for extinction. Acute stress produced resistance to extinction, as well as dendritic retraction in infralimbic cortex. Spine density on apical and basilar terminal branches was unaffected by stress. However, animals that underwent conditioning and extinction had decreased spine density on apical terminal branches. Thus, whereas dendritic morphology in infralimbic cortex appears to be particularly sensitive to stress, changes in spines may more sensitively reflect learning. Further, in stressed rats that underwent conditioning and extinction, the level of extinction learning was correlated with spine densities, in that rats with poorer extinction retrieval had more immature spines and fewer thin spines than rats with better extinction retrieval, suggesting that stress may have impaired learning-related spine plasticity. These results may have implications for understanding the role of medial prefrontal cortex in learning deficits associated with stress-related pathologies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The infralimbic cortex is involved in coping with chronic stress, eventually leading to structural changes and prefrontal dysfunction.
“The most ventral subdomain of the mPFC is the infralimbic cortex (IL) and is involved in coping with chronic stress eventually leading to structural changes and prefrontal dysfunction [5–11].”
From Development of prefrontal cortex (2022) · cites this paper as [7]
The Discussion (Stress-induced changes in IL dendritic morphology; page unavailable) reports dendritic retraction in infralimbic cortex following chronic stress, and the Conclusion links the study’s findings to stress-induced medial prefrontal dysfunction. The paper does not specifically describe the infralimbic cortex as coping with chronic stress or establish that chronic-stress-related structural changes lead to prefrontal dysfunction; its own experiment examined acute stress. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Effects of an expanding-spaced vs massed exposure schedule on fear reduction and return of fear
Rowe, M. K., & Craske, M. G. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)10016-x · Cited by 1,778 · see citing works
Stress, memory and the amygdala
Roozendaal, B., McEwen, B. S., & Chattarji, S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2651 · Cited by 1,760 · see citing works
Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06810.2002 · Cited by 1,662 · see citing works
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645 · see citing works
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365 · see citing works
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277 · see citing works
Designing Experiments and Analysing Data: A Model Comparison Perspective.
Freeman, G. H., Maxwell, S. E., & Delaney, H. D. (1991) · Biometrics · doi:10.2307/2532173 · Cited by 1,229 · see citing works
Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190 · see citing works
Woolley, C. S., Gould, E., & McEwen, B. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90778-a · Cited by 1,020 · see citing works
Harris, K. M., Jensen, F. E., & Tsao, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02685.1992 · Cited by 990 · see citing works
The role of ventromedial prefrontal cortex in the recovery of extinguished fear
Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06225.2000 · Cited by 957 · cited 4× · see citing works
“Lesions (Quirk et al., 2000), temporary inactivation (Sierra-Mercado et al., 2011), or inhibition of protein synthesis in IL (Santini et al., 2004) impairs extinction retrieval, which is rescued in chronically stressed animals with IL lesions (Farrell et al., 2010).”
BackgroundInfluentialRepeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex
Radley, J. J., Rocher, A. B., Miller, M., Janssen, W. G. M., Liston, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi104 · Cited by 820 · see citing works
Innate and conditioned reactions to threat in rats with amygdaloid lesions.
Blanchard, D. C., & Blanchard, R. J. (1972) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0033521 · Cited by 753 · see citing works
Chronic stress alters dendritic morphology in rat medial prefrontal cortex
Cook, S. C., & Wellman, C. L. (2004) · Journal of Neurobiology · doi:10.1002/neu.20025 · Cited by 750 · see citing works
Self-citationThe small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines
Peters, A., & Kaiserman‐Abramof, I. R. (1970) · American Journal of Anatomy · doi:10.1002/aja.1001270402 · Cited by 740 · see citing works
Designing experiments and analyzing data: a model comparison perspective
(1990) · Choice Reviews Online · doi:10.5860/choice.28-2192 · Cited by 673 · see citing works
Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala
Mitra, R., Jadhav, S., McEwen, B. S., Vyas, A., & Chattarji, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504011102 · Cited by 663 · see citing works
Wellman, C. L. (2001) · Journal of Neurobiology · doi:10.1002/neu.1079 · Cited by 594 · see citing works
Self-citationPrice, J. L. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901500105 · Cited by 530 · see citing works
Behavioural stress facilitates the induction of long-term depression in the hippocampus
Xu, L., Anwyl, R., & Rowan, M. J. (1997) · Nature · doi:10.1038/387497a0 · Cited by 509 · see citing works
Neuronal circuits of fear extinction
Herry, C., Ferraguti, F., Singewald, N., Letzkus, J. J., Ehrlich, I., & Lüthi, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07101.x · Cited by 484 · see citing works
Consolidation of Fear Extinction Requires Protein Synthesis in the Medial Prefrontal Cortex
Santini, E., Ge, H., Ren, K., de Ortiz, S. P., & Quirk, G. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0786-04.2004 · Cited by 479 · see citing works
Izquierdo, A., Wellman, C. L., & Holmes, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0474-06.2006 · Cited by 459 · see citing works
Self-citationVyas, A., Pillai, A. G., & Chattarji, S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.013 · Cited by 445 · see citing works
Neural and cellular mechanisms of fear and extinction memory formation
Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429 · see citing works
Maren, S., & Holmes, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.180 · Cited by 412 · see citing works
Opposite effects of fear conditioning and extinction on dendritic spine remodelling.
Lai, C. S. W., Franke, T. F., & Gan, W.-B. (2012) · Nature · doi:10.1038/nature10792 · Cited by 392 · see citing works
Glaser, E. M., & der Loos, H. V. (1981) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(81)90045-5 · Cited by 374 · see citing works
Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
Radley, J. J., Rocher, A. B., Rodriguez, A., Ehlenberger, D. B., Dammann, M., McEwen, B. S., Morrison, J. H., Wearne, S. L., & Hof, P. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21588 · Cited by 374 · see citing works
Phenytoin prevents stress‐ and corticosterone‐induced atrophy of CA3 pyramidal neurons
Watanabe, Y., Gould, E., Cameron, H. A., Daniels, D. C., & McEwen, B. S. (1992) · Hippocampus · doi:10.1002/hipo.450020410 · Cited by 350 · see citing works
Liu, R.-J., & Aghajanian, G. K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706679105 · Cited by 346 · see citing works
Mild, Short-term Stress Alters Dendritic Morphology in Rat Medial Prefrontal Cortex
Brown, S. M., Henning, S., & Wellman, C. L. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi048 · Cited by 335 · see citing works
Self-citationGoldwater, D. S., Pavlides, C., Hunter, R. G., Bloss, E. B., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.053 · Cited by 333 · see citing works
Govindarajan, A., Rao, B. S. S., Nair, D., Trinh, M. A., Mawjee, N., Tonegawa, S., & Chattarji, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605180103 · Cited by 332 · see citing works
Herry, C., & Garcia, R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00577.2002 · Cited by 323 · see citing works
McLaughlin, K. J., Gomez, J. L., Baran, S. E., & Conrad, C. D. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.042 · Cited by 312 · see citing works
Acute Stress-induced Changes in Hippocampal/Prefrontal Circuits in Rats: Effects of Antidepressants
Rocher, C. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhg122 · Cited by 307 · see citing works
Prolonged behavioral stress enhances synaptic connectivity in the basolateral amygdala
Vyas, A., Jadhav, S., & Chattarji, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.003 · Cited by 299 · see citing works
Maroun, M., & Richter-Levin, G. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04406.2003 · Cited by 293 · see citing works
Self-citationAkirav, I., & Maroun, M. (2007) · Neural Plasticity · doi:10.1155/2007/30873 · Cited by 277 · see citing works
Self-citationChronic stress impairs recall of extinction of conditioned fear
Miracle, A. D., BRACE, M., HUYCK, K., SINGLER, S., & Wellman, C. L. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.10.005 · Cited by 217 · see citing works
Self-citationGarrett, J., & Wellman, C. L. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.057 · Cited by 215 · see citing works
Self-citationDiamond, D. M., Campbell, A. M., Park, C. R., Woodson, J. C., Conrad, C. D., Bachstetter, A. D., & Mervis, R. F. (2006) · Hippocampus · doi:10.1002/hipo.20188 · Cited by 213 · see citing works
Estrogen Promotes Stress Sensitivity in a Prefrontal Cortex-Amygdala Pathway
Shansky, R. M., Hamo, C., Hof, P. R., Lou, W., McEwen, B. S., & Morrison, J. H. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq003 · Cited by 191 · see citing works
Kim, J. J., Fanselow, M. S., DeCola, J. P., & Landeira-Fernández, J. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.4.591 · Cited by 165 · see citing works
Maier, S. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.003 · Cited by 143 · see citing works
Chronic stress-induced hippocampal dendritic retraction requires CA3 NMDA receptors
Christian, K. M., Miracle, A. D., Wellman, C. L., & Nakazawa, K. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.033 · Cited by 138 · see citing works
Self-citationNMDA Receptor Blockade Alters Stress-Induced Dendritic Remodeling in Medial Prefrontal Cortex
Martin, K. P., & Wellman, C. L. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr021 · Cited by 138 · see citing works
Self-citationKim, J. J., Fanselow, M. S., DeCola, J. P., et al. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.4.591 · Cited by 129 · see citing works
Garcia, R., Spennato, G., Nilsson-Todd, L., Moreau, J., & Deschaux, O. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.10.005 · Cited by 126 · see citing works
Hikind, N., & Maroun, M. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.03.003 · Cited by 124 · see citing works
Self-citationRadley, J. J., Anderson, R. M., Hamilton, B. A., Alcock, J. A., & Romig‐Martin, S. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0287-13.2013 · Cited by 121 · see citing works
Delatour, B., & Witter, M. P. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01973.x · Cited by 117 · see citing works
Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction
Wilber, A. A., Walker, A. G., Southwood, C. J., Farrell, M. R., Lin, G. L., Rebec, G. V., & Wellman, C. L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.070 · Cited by 115 · see citing works
Self-citationHolmes, A., & Quirk, G. J. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.10.003 · Cited by 107 · see citing works
Maroun, M. (2012) · The Neuroscientist · doi:10.1177/1073858412464527 · Cited by 105 · see citing works
Self-citationDaily injections alter spine density in rat medial prefrontal cortex
Seib, L. M., & Wellman, C. L. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01287-9 · Cited by 100 · see citing works
Self-citationMulder, A. B., Arts, M. P. M., & Lopes, F. H. D. S. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01518.x · Cited by 99 · see citing works
Cortical Region Interactions and the Functional Role of Apical Dendrites
Spratling, M. (2002) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582302001003003 · Cited by 99 · see citing works
Bidirectional shift in the cornu ammonis 3 pyramidal dendritic organization following brief stress
Kole, M. H. P., Costoli, T., Koolhaas, J. M., & Fuchs, E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.02.014 · Cited by 96 · see citing works
Vouimba, R., & Maroun, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.115 · Cited by 88 · see citing works
Self-citationMaroun, M., Ioannides, P. J., Bergman, K. L., Kavushansky, A., Holmes, A., & Wellman, C. L. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12259 · Cited by 86 · see citing works
Self-citationMaroun, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05169.x · Cited by 82 · see citing works
Self-citationStress and Amygdala Suppression of Metaplasticity in the Medial Prefrontal Cortex
Richter‐Levin, G., & Maroun, M. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp311 · Cited by 79 · see citing works
Self-citationNeural pathways of stress integration: relevance to alcohol abuse
Herman, J. P. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.08 · Cited by 77 · see citing works
Padival, M., Blume, S. R., & Rosenkranz, J. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.061 · Cited by 66 · see citing works
Farrell, M. R., Sayed, J. A., Underwood, A. R., & Wellman, C. L. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.06.001 · Cited by 51 · see citing works
Self-citationAkirav, I., Segev, A., Motanis, H., & Maroun, M. (2009) · Learning & Memory · doi:10.1101/lm.1565109 · Cited by 51 · see citing works
Self-citationMoench, K. M., & Wellman, C. L. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.12.035 · Cited by 41 · see citing works
Self-citationGrillo, C. A., Risher, M., Macht, V. A., Bumgardner, A. L., Hang, A., Gabriel, C., Mocaër, E., Piroli, G. G., Fadel, J. R., & Reagan, L. P. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.047 · Cited by 38 · see citing works
Sajikumar, S., & Körte, M. (2011) · Learning & Memory · doi:10.1101/lm.2095811 · Cited by 32 · see citing works
Schayek, R., & Maroun, M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.004 · Cited by 32 · see citing works
Self-citationMonoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress
Godar, S. C., Bortolato, M., Richards, S. E. V., Li, F. G., Chen, K., Wellman, C. L., & Shih, J. C. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv035 · Cited by 23 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Zilles K. Wree A. Cortex: areal and laminal structure Paxinos G. The Rat Nervous System 1995 Academic Press San Diego, CA 649 685
Cited by
Sorted by citations
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
Czéh, B., Vardya, I., Varga, Z., Febbraro, F., Csabai, D., Martis, L., Højgaard, K., Henningsen, K., Bouzinova, E. V., Miseta, A., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00148 · Cited by 129 · see citing works
Csabai, D., Wiborg, O., & Czéh, B. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00024 · Cited by 100 · see citing works
Zimmermann, K. S., Richardson, R., & Baker, K. (2019) · Brain Sciences · doi:10.3390/brainsci9030065 · Cited by 105 · see citing works
Burleson, C. A., Pedersen, R. W., Seddighi, S., DeBusk, L. E., Burghardt, G. M., & Cooper, M. A. (2016) · Behavioral Neuroscience · doi:10.1037/bne0000148 · Cited by 69 · see citing works
Diniz, C. R. A. F., & Crestani, A. P. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01931-x · Cited by 67 · see citing works
A Focus on the Functions of Area 25
Alexander, L., Clarke, H. F., & Roberts, A. (2019) · Brain Sciences · doi:10.3390/brainsci9060129 · Cited by 63 · see citing works
Moench, K. M., & Wellman, C. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.049 · Cited by 63 · see citing works
Self-citationPrefrontal Regulation of Threat-Elicited Behaviors: A Pathway to Translation
Roberts, A. C. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-010419-050905 · Cited by 50 · see citing works
Wellman, C. L., Bollinger, J. L., & Moench, K. M. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.11.007 · Cited by 53 · see citing works
Self-citationImpact of Stress and Glucocorticoids on Schema-Based Learning
Kluen, L. M., Nixon, P., Agorastos, A., Wiedemann, K., & Schwabe, L. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.256 · Cited by 51 · see citing works
Saravia, R., Ten-Blanco, M., Julià‐Hernández, M., Gagliano, H., Andero, R., Armario, A., Maldonado, R. J., & Berrendero, F. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.016 · Cited by 37 · see citing works
Know thy SEFL: Fear sensitization and its relevance to stressor-related disorders
Nishimura, K., Poulos, A. M., Drew, M. R., & Rajbhandari, A. K. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104884 · Cited by 35 · see citing works
Wellman, C. L., & Moench, K. M. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5023-4 · Cited by 31 · see citing works
Self-citationAgo, Y., Hayata‐Takano, A., Kawanai, T., Yamauchi, R., Takeuchi, S., Cushman, J. D., Rajbhandari, A. K., Fanselow, M. S., Hashimoto, H., & Waschek, J. A. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.10.010 · Cited by 28 · see citing works
Breach, M. R., Moench, K. M., & Wellman, C. L. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22723 · Cited by 26 · see citing works
Self-citationRyan, S. J., Li, C., Menigoz, A., Hazra, R., Dabrowska, J., Ehrlich, D., Gordon, K. M., & Rainnie, D. G. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1575-z · Cited by 18 · see citing works
Paredes, D., Knippenberg, A. R., & Morilak, D. A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01171-7 · Cited by 18 · see citing works
Paredes, D., Knippenberg, A. R., Bulin, S. E., Keppler, L. J., & Morilak, D. A. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100468 · Cited by 16 · see citing works
Lguensat, A., Bentefour, Y., Bennis, M., Ba-M’hamed, S., & Garcia, R. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.08.018 · Cited by 16 · see citing works
Dorze, C. L., Borreca, A., Pignataro, A., Ammassari‐Teule, M., & Gisquet-Verrier, P. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0714-0 · Cited by 16 · see citing works
Su, X., Xia, C., Wang, W., Sun, H., Tan, Q., Zhang, S., Li, L., Kemp, G. J., Yue, Q., & Gong, Q. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.018 · Cited by 15 · see citing works
Mattera, A., Pagani, M., & Baldassarre, G. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.569108 · Cited by 15 · see citing works
Timing is everything: differential effects of chronic stress on fear extinction
Chakraborty, P., & Chattarji, S. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5053-y · Cited by 14 · see citing works
Qin, Y. F., Hu, X., Zhao, H., Kurban, N., Chen, X., Yi, J., Zhang, Y., Cui, S., & Zhang, Y.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137496 · Cited by 13 · see citing works
Rigid patterns of effortful choice behavior after acute stress in rats
Hart, E. E., Stolyarova, A., Conoscenti, M. A., Minor, T. R., & Izquierdo, A. (2016) · Stress · doi:10.1080/10253890.2016.1258397 · Cited by 8 · see citing works
Vafaei, A. A., Rashidy‐Pour, A., Tarahomi, P., Omoumi, S., & Dadkhah, M. (2021) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.2021.2161.1 · Cited by 7 · see citing works
Csabai, D., Sebők-Tornai, A., Wiborg, O., & Czéh, B. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.885849 · Cited by 7 · see citing works
Zhu, W., Zhang, W., Yang, F., Cai, M., Li, X., Xiang, Y., Xiang, J. Y., Yang, Y., & Cai, D.-F. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1108494 · Cited by 5 · see citing works
Wellman, C. L. (2017) · Current Protocols in Neuroscience · doi:10.1002/cpns.18 · Cited by 5 · see citing works
Self-citationAcute stress yields a sex-dependent facilitation of signaled active avoidance in rats
Plas, S. L., Oleksiak, C. R., Pitre, C., Melton, C., Moscarello, J. M., & Maren, S. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100656 · Cited by 3 · see citing works
A salience hypothesis of stress in PTSD
Chakraborty, P., Chattarji, S., & Jeanneteau, F. D. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15526 · Cited by 5 · see citing works
Storsved, H., Haseman, A. D. T., Liu, M., Stewart-Allen, R., Rajavelu, C., & Wellman, C. L. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.05.019 · Cited by 2 · see citing works
Self-citationDendritic Spine Plasticity and Memory Formation
Ammassari‐Teule, M., & Segal, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21113-9 · Cited by 1 · see citing works
Zhang, Y., Zhao, H., Yi, J., Kurban, N., Cui, S., Chen, X., Hu, X., Zhang, Y., Yu, Q., & Zhang, Y. (2023) · Progress in Neurobiology · doi:10.60124/j.pneuro.2023.30.05
Qin, Y. F., Cui, S., Hu, X., Zhao, H., Kurban, N., Chen, X., Yi, J., Zhang, Y., & Zhang, Y. (2022) · doi:10.22541/au.166333507.78967420/v1
Raftopoulos, A. (2025) · Studies in applied philosophy, epistemology and rational ethics · doi:10.1007/978-3-031-91213-9_5
Andrys, N. R. R., Johnson, E. A., Rowe, E. B., Millisor, L., McDole, B. K., Baratta, M. V., Radley, J. J., & Spencer, R. L. (2026) · Brain Structure and Function · doi:10.1007/s00429-026-03176-8
Daneluz, D. M., dos Santos, A. S., de Melo, S. R., de Oliveira, R. M. W., & Stern, C. A. J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06264-2
- Authors
- Moench, K. M., Maroun, M., Kavushansky, A., & Wellman, C.
- Affiliations
- Indiana University Bloomington (US)
- University of Haifa (IL)
- Corresponding author
- Wellman, Cara
- Venue
- Neurobiology of Stress
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 3
- Pages
- 23-33
- ISSN
- 2352-2895 (ISSN-L)
- PMC
- PMC4730795
- OpenAlex
- W2220058171
- Cited by
- 41
- References
- 73
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 3
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neurobiology of Stress (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- US-Israel Binational Science Foundation (2013292)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- infralimbic cortex, fear extinction, acute stress, dendritic morphology, dendritic retraction, dendritic spine density, spine plasticity, medial prefrontal cortex, corticolimbic circuits, post-traumatic stress disorder, extinction retrieval
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
