CoChat
Sign Up
Cited by 394Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNerve injury and regeneration

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms

Cassilhas, R.C., Lee, K.S., Fernandes, J., Oliveira, M.G.M., Tufik, S., Meeusen, R., de Mello, M.T.·2012·Neuroscience
DOI 10.1016/j.neuroscience.2011.11.029
Open this paper in CoChat — free account

Abstract

A growing body of scientific evidence indicates that exercise has a positive impact on human health, including neurological health. Aerobic exercise, which is supposed to enhance cardiovascular functions and metabolism, also induces neurotrophic factors that affect hippocampal neurons, thereby improving spatial learning and memory. Alternatively, little is known about the effect of resistance exercise on hippocampus-dependent memory, although this type of exercise is increasingly recommended to improve muscle strength and bone density and to prevent age-related disabilities. Therefore, we evaluated the effects of resistance training on spatial memory and the signaling pathways of brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1), comparing these effects with those of aerobic exercise. Adult male Wistar rats underwent 8 weeks of aerobic training on a treadmill (AERO group) or resistance training on a vertical ladder (RES group). Control and sham groups were also included. After the training period, both AERO and RES groups showed improved learning and spatial memory in a similar manner. However, both groups presented distinct signaling pathways. Although the AERO group showed increased level of IGF-1, BDNF, TrkB, and β-CaMKII (calcium/calmodulin-dependent kinase II) in the hippocampus, the RES group showed an induction of peripheral and hippocampal IGF-1 with concomitant activation of receptor for IGF-1 (IGF-1R) and AKT in the hippocampus. These distinct pathways culminated in an increase of synapsin 1 and synaptophysin expression in both groups. These findings demonstrated that both aerobic and resistance exercise can employ divergent molecular mechanisms but achieve similar results on learning and spatial memory.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.neuroscience.2011.11.029

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 394

Related

See all

Metadata

Authors
Cassilhas, R. C., Lee, K. S., Fernandes, J., Oliveira, M. G. M., Tufik, S., Meeusen, R., & de Mello, M. T.
Affiliations
  • Universidade Federal de São Paulo (BR)
  • Vrije Universiteit Brussel (BE)
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2012-01
Volume
202
Pages
309-317
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2011.11.029
OpenAlex
W2146864294
Cited by
394
References
74
Citations by year
2026: 21 · 2025: 30 · 2024: 26 · 2023: 34 · 2022: 26 · 2021: 36 · 2020: 34 · 2019: 35 · 2018: 34 · 2017: 23 · 2016: 28 · 2015: 23 · 2014: 21 · 2013: 15 · 2012: 8
FWCI
4.60
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Funders
São Paulo Research Foundation (2008/03083-6)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
spatial memory, aerobic exercise, resistance training, hippocampus, brain-derived neurotrophic factor, insulin-like growth factor I, IGF-1 receptor, Akt signaling, TrkB, CaMKII, synapsin-1, synaptophysin, neurotrophic factors, exercise and cognition
MeSH terms
Animals, Corticosterone, Enzyme-Linked Immunosorbent Assay, Hippocampus, Insulin-Like Growth Factor I, Male, Memory, Physical Conditioning, Animal, Radioimmunoassay, Space Perception, Blotting, Western, Signal Transduction, Synapsins, Rats, Wistar, Receptor, IGF Type 1, Maze Learning, Brain-Derived Neurotrophic Factor, Receptor, trkB, Oncogene Protein v-akt, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Resistance Training

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review