Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice

Molecular Cell Biology

Lodish, H. F. (1986) · Cited by 5,640 · see citing works

Running enhances neurogenesis, learning, and long-term potentiation in mice

van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works

Exercise: a behavioral intervention to enhance brain health and plasticity

Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739 · see citing works

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition

Vaynman, S., Ying, Z., & Gomez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03720.x · Cited by 1,460 · see citing works

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

Smith, M., Makino, S., Květňanský, R., & Post, R. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01768.1995 · Cited by 1,429 · see citing works

Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

Neeper, S. A., Gómez‐Pinilla, F., Choi, J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/0006-8993(96)00273-9 · Cited by 1,015 · see citing works

Essential Role for TrkB Receptors in Hippocampus-Mediated Learning

Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799 · see citing works

From Acquisition to Consolidation: On the Role of Brain-Derived Neurotrophic Factor Signaling in Hippocampal-Dependent LearningPreprint

Tyler, W. J., Alonso, M., Bramham, C. R., & Pozzo‐Miller, L. D. (2002) · Learning & Memory · doi:10.1101/lm.51202 · Cited by 679 · see citing works

Brain-Derived Neurotrophic Factor/TrkB Signaling in Memory Processes

Yamada, K., & Nabeshima, T. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.91.267 · Cited by 585 · see citing works

Involvement of Brain-Derived Neurotrophic Factor in Spatial Memory Formation and Maintenance in a Radial Arm Maze Test in Rats

Mizuno, M., Yamada, K., Olariu, A., Nawa, H., & NABESHIMA, T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-07116.2000 · Cited by 549 · see citing works

Synaptotagmin: A Ca2+ sensor that triggers exocytosis?

Chapman, E. (2002) · Nature reviews. Molecular cell biology · doi:10.1038/nrm855 · Cited by 487 · see citing works

Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling

Eide, F. F., Vining, E. R., Eide, B. L., Zang, K., Wang, X., & Reichardt, L. F. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03123.1996 · Cited by 473 · see citing works

Differential effects of acute and chronic exercise on plasticity‐related genes in the rat hippocampus revealed by microarray

Molteni, R., Ying, Z., & Gómez‐Pinilla, F. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02158.x · Cited by 441 · see citing works

Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity

Vaynman, S., Ying, Z., & Gomez-Pinilla, F. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.001 · Cited by 396 · see citing works

Regular exercise improves cognitive function and decreases oxidative damage in rat brain

Radak, Z. O., Kaneko, T., Tahara, S., Nakamoto, H., Pucsok, J. M., Sasvári, M., Nyakas, C. J., & Goto, S. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00063-2 · Cited by 373 · see citing works

Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B Involvement in Amygdala-Dependent Fear Conditioning

Rattiner, L. M., Davis, M., French, C. T., & Ressler, K. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5654-03.2004 · Cited by 360 · see citing works

Effects of Exercise on Gene-Expression Profile in the Rat Hippocampus

Tong, L., Shen, H., Perreau, V. M., Balázs, R., & Cotman, C. W. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0427 · Cited by 325 · see citing works

Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

Vaynman, S., & Gomez‐Pinilla, F. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20979 · Cited by 299 · see citing works

Brain monoamines, exercise, and behavioral stress: animal models

DISHMAN, R. K. (1997) · Medicine &amp Science in Sports &amp Exercise · doi:10.1097/00005768-199701000-00010 · Cited by 291 · see citing works

Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats

Mu, J.-S., Li, W., Yao, Z., & Zhou, X. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01592-9 · Cited by 282 · see citing works

Stress effects in the hippocampus: Synaptic plasticity and memory

Kim, J. J., Song, E. Y., Kim, J. J., Song, E. Y., & Kosten, T. A. (2006) · Stress · doi:10.1080/10253890600678004 · Cited by 255 · see citing works

Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice

Fordyce, D. E., & Wehner, J. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91602-o · Cited by 251 · see citing works

Exercise differentially regulates synaptic proteins associated to the function of BDNF

Vaynman, S. S., Ying, Z., Yin, D., & Gomez-Pinilla, F. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.062 · Cited by 248 · see citing works

Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation in rats

Ma, Y., Wang, H. L., Wu, H., Wei, C. L., & Lee, E. H. Y. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00325-4 · Cited by 231 · see citing works

Protein Synthesis-dependent and -independent Regulation of Hippocampal Synapses by Brain-derived Neurotrophic Factor

Tartaglia, N. R., Du, J., Tyler, W. J., Neale, E. A., Pozzo‐Miller, L. D., & Lu, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101683200 · Cited by 180 · see citing works

Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB–PLCγ pathway, reduced anxiety, and facilitated learning

Koponen, E., Võikar, V., Riekki, R., Saarelainen, T., Rauramaa, T., Rauvala, H., Taira, T., & Castrén, E. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.01.006 · Cited by 170 · see citing works

Involvement of BDNF Receptor TrkB in Spatial Memory FormationPreprint

Mizuno, M., Yamada, K., He, J., Nakajima, A., & Nabeshima, T. (2003) · Learning & Memory · doi:10.1101/lm.56003 · Cited by 170 · see citing works

Compulsive exercise acutely upregulates rat hippocampal brain-derived neurotrophic factor

Huang, A. M., Jen, C. J., Chen, H. F., Yu, L., Kuo, Y. M., & Chen, H. I. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-005-0359-4 · Cited by 155 · see citing works

Effect of exercise on longevity, body weight, locomotor performance, and passive-avoidance memory of C57BL/6J mice

Samorajski, T., Delaney, C., Durham, L., Ordy, J. M., Johnson, J. A., & Dunlap, W. P. (1985) · Neurobiology of Aging · doi:10.1016/0197-4580(85)90066-1 · Cited by 147 · see citing works

Alterations in spatial learning and memory after forced exercise

Ang, E.-T., Dawe, G. S., Wong, P. T. H., Moochhala, S., & Ng, Y.-K. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.023 · Cited by 144 · see citing works

Truncated trkB.T1 Is Dominant Negative Inhibitor of trkB.TK+-Mediated Cell Survival

Haapasalo, A., Koponen, E., Hoppe, E., Wong, G., & Ċastrén, E. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4296 · Cited by 126 · see citing works

Deficits in memory and motor performance in synaptotagmin IV mutant mice.

Ferguson, G. D., Anagnostaras, S., Silva, A. J., & Herschman, H. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.100104597 · Cited by 108 · see citing works

Transcriptional Regulation of Brain-Derived Neurotrophic Factor in the Amygdala during Consolidation of Fear Memory

Ou, L.-C., & Gean, P. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.034934 · Cited by 106 · see citing works

Treadmill exercise enhances passive avoidance learning in rats: The role of down-regulated serotonin system in the limbic system

Chen, H.-I., Lin, L.-C., Yu, L., Liu, Y.-F., Kuo, Y.-M., Huang, A.-M., Chuang, J.-I., Wu, F.-S., Liao, P.-C., & Jen, C. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.004 · Cited by 79 · see citing works

SNAP‐25 in hippocampal CA1 region is involved in memory consolidation

Hou, Q., Gao, X., Zhang, X., Kong, L., Wang, X., Bian, W., Tu, Y., Jin, M., Zhao, G., Li, B., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03600.x · Cited by 74 · see citing works

Treadmill running reverses retention deficit induced by morphine

Alaei, H., Borjeian, L., Azizi, M., Orian, S., Pourshanazari, A., & Hänninen, O. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.02.025 · Cited by 72 · see citing works

Impaired Memory Retention and Decreased Long-Term Potentiation in Integrin-Associated Protein-Deficient MicePreprint

Chang, H. P., Lindberg, F. P., Wang, H. L., Huang, A., & Lee, E. H. Y. (1999) · Learning & Memory · doi:10.1101/lm.6.5.448 · Cited by 68 · see citing works

Altered hippocampal short‐term plasticity and associative memory in synaptotagmin IV (−/−) mice

Ferguson, G. D., Wang, H., Herschman, H. R., & Storm, D. R. (2004) · Hippocampus · doi:10.1002/hipo.20013 · Cited by 60 · see citing works

A comparison of the effects of scopolamine and diazepam on acquisition and retention of inhibitory avoidance in mice

Decker, M. W., Tran, T. T. T., & McGaugh, J. L. (1990) · Psychopharmacology · doi:10.1007/bf02244005 · Cited by 54 · see citing works

Bridging animal and human models of exercise-induced brain plasticity

Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030 · see citing works

Exercise and the brain: something to chew on

van Praag, H. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.007 · Cited by 599 · see citing works

The neuropathology of sport

McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422 · see citing works

All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis

Vivar, C., Potter, M. C., & van Praag, H. (2012) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_220 · Cited by 370 · see citing works

Pro-cognitive properties of T cells

Kipnis, J., Gadani, S., & Derecki, N. C. (2012) · Nature Reviews Immunology · doi:10.1038/nri3280 · Cited by 246 · see citing works

The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging

Vecchio, L. M., Meng, Y., Xhima, K., Lipsman, N., Hamani, C., & Aubert, I. (2018) · Brain Plasticity · doi:10.3233/bpl-180069 · Cited by 230 · see citing works

Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I

Liu, Y., Chen, H., Wu, C., Kuo, Y., Yu, L., Huang, A., Wu, F., Chuang, J., & Jen, C. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173088 · Cited by 199 · see citing works

The effects of aerobic exercise intensity and duration on levels of brain-derived neurotrophic factor in healthy men.

SCHMOLESKY, M. T., Webb, D. L., & Hansen, R. A. (2013) · Europe PMC (PubMed Central) · Cited by 149 · see citing works

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer’s disease transgenic mice

Kimura, R., Devi, L., & Ohno, M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06608.x · Cited by 139 · see citing works

Physical Exercise Enhances Neuroplasticity and Delays Alzheimer’s Disease

Lin, T.-W., Tsai, S., & Kuo, Y. (2018) · Brain Plasticity · doi:10.3233/bpl-180073 · Cited by 146 · see citing works

Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction

Cefis, M., Chaney, R., Wirtz, J., Méloux, A., Quirié, A., Leger, C., Prigent‐Tessier, A., & Garnier, P. E. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1275924 · Cited by 130 · see citing works

Different types of exercise induce differential effects on neuronal adaptations and memory performance

Lin, T.-W., Chen, S.-J., Huang, T.-Y., Chang, C.-Y., Chuang, J., Wu, F., Kuo, Y., & Jen, C. J. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.10.006 · Cited by 122 · see citing works

A behavioral analysis of the impact of voluntary physical activity on hippocampus‐dependent contextual conditioning

Greenwood, B. N., Strong, P. V., Foley, T. E., & Fleshner, M. (2008) · Hippocampus · doi:10.1002/hipo.20534 · Cited by 106 · see citing works

Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF

Choi, S. H., Li, Y., Parada, L. F., & Sisodia, S. S. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-52 · Cited by 106 · see citing works

Interaction between serum BDNF and aerobic fitness predicts recognition memory in healthy young adults

Whiteman, A., Young, D. E., He, X., Chen, T. C., WAGENAAR, R. C., Stern, C. E., & Schön, K. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.023 · Cited by 104 · see citing works

Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice

Ieraci, A., Madaio, A. I., Mallei, A., Lee, F. S., & Popoli, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.120 · Cited by 103 · see citing works

Neuroprotective Effects of Exercise Treatments after Injury: The Dual Role of Neurotrophic Factors

Cobianchi, S., Arbat-Plana, A., Lopez-Alvarez, V. M., & Navarro, X. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160330105132 · Cited by 94 · see citing works

TrkB reduction exacerbates Alzheimer’s disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice

Devi, L., & Ohno, M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.55 · Cited by 92 · see citing works

Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice

Giménez‐Llort, L., García, Y., Buccieri, K., Revilla, S., Sunol, C. E., Cristòfol, R. M., & Sanfeliu, C. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/128354 · Cited by 89 · see citing works

Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability

Wan, R., Weigand, L. A., Bateman, R., Griffioen, K. J. S., Mendelowitz, D., & Mattson, M. P. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12656 · Cited by 87 · see citing works

The effect of exercise on memory and BDNF signaling is dependent on intensity

Cefis, M., Prigent‐Tessier, A., Quirié, A., Pernet, N., Marie, C., & Garnier, P. E. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01889-7 · Cited by 84 · see citing works

Exercise Neuroprotection in a Rat Model of Binge Alcohol Consumption

Leasure, J. L., & Nixon, K. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01105.x · Cited by 83 · see citing works

Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus

Hu, S., Ying, Z., Gomez-Pinilla, F., & Frautschy, S. A. (2009) · Brain Research · doi:10.1016/j.brainres.2008.10.054 · Cited by 79 · see citing works

GABAA Receptor Blockade Enhances Memory Consolidation by Increasing Hippocampal BDNF Levels

Kim, D. H., Kim, J. M., Park, S. J., Cai, M., Liu, X., Lee, S., Shin, C. Y., & Ryu, J. H. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.189 · Cited by 75 · see citing works

Aerobic exercise interacts with neurotrophic factors to predict cognitive functioning in adolescents

Lee, T. M. C., Wong, M. L., Lau, B. W.-M., Lee, J. C.-D., Yau, S., & So, K. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.019 · Cited by 74 · see citing works

The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review

Ribeiro, D., Petrigna, L., Pereira, F. C., Muscella, A., Bianco, A., & Tavares, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168814 · Cited by 72 · see citing works

Age-Related Neurodegeneration and Memory Loss in Down Syndrome

Lockrow, J. P., Fortress, A. M., & Granholm, A. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/463909 · Cited by 64 · see citing works

Physical Activity, Cognitive Function, and Brain Health: What Is the Role of Exercise Training in the Prevention of Dementia?

Gregory, S. M., Parker, B. A., & Thompson, P. D. (2012) · Brain Sciences · doi:10.3390/brainsci2040684 · Cited by 64 · see citing works

Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome

Llorens-Martı́n, M., Rueda, N., Tejeda, G. S., Flórez, J., Trejo, J. L., & Martínez‐Cué, C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.043 · Cited by 63 · see citing works

Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes

Shima, T., Matsui, T., Jesmin, S., Okamoto, M., Soya, M., Inoue, K., Liu, Y.-F., Torres‐Alemán, I., McEwen, B. S., & Soya, H. (2016) · Diabetologia · doi:10.1007/s00125-016-4164-4 · Cited by 62 · see citing works

Exercise effects on brain and behavior in healthy mice, Alzheimer’s disease and Parkinson’s disease model—A systematic review and meta-analysis

da Costa Daniele, T. M., de Bruin, P. F. C., de Matos, R. S., de Bruin, G. S., Maia Chaves, C., & de Bruin, V. M. S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112488 · Cited by 59 · see citing works

A bout of voluntary running enhances context conditioned fear, its extinction, and its reconsolidationPreprint

Siette, J., Reichelt, A. C., & Westbrook, R. F. (2014) · Learning & Memory · doi:10.1101/lm.032557.113 · Cited by 58 · see citing works

Effect of exercise on microglial activation and transcriptome of hippocampus in fluorosis mice

Wang, J., Yue, B., Zhang, X., Guo, X., Sun, Z., & Niu, R. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143376 · Cited by 57 · see citing works

Late‐life physical activity relates to brain tissue synaptic integrity markers in older adults

Casaletto, K., Ramos‐Miguel, A., VandeBunte, A., Memel, M., Buchman, A., Bennett, D., & Honer, W. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12530 · Cited by 53 · see citing works

Neuroprotective Effects of Physical Activity via the Adaptation of Astrocytes

Maugeri, G., D’Agata, V., Magrì, B., Roggio, F., Castorina, A., Ravalli, S., Rosa, M. D., & Musumeci, G. (2021) · Cells · doi:10.3390/cells10061542 · Cited by 52 · see citing works

BDNF-TrkB signalling in fear learning: from genetics to neural networks

Musumeci, G., & Minichiello, L. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.031 · Cited by 50 · see citing works

Intensity-dependent effects of consecutive treadmill exercise on spatial learning and memory through the p-CREB/BDNF/NMDAR signaling in hippocampus

Wu, Y., Deng, F., Wang, J., Liu, Y., Zhou, W., Qu, L., & Cheng, M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112599 · Cited by 53 · see citing works

Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin

Leger, C., Quirié, A., Méloux, A., Fontanier, E., Chaney, R., Basset, C., Lemaire‐Ewing, S., Garnier, P. E., & Prigent‐Tessier, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021213 · Cited by 49 · see citing works

Long Term Running Biphasically Improves Methylglyoxal-Related Metabolism, Redox Homeostasis and Neurotrophic Support within Adult Mouse Brain Cortex

Falone, S., D'Alessandro, A., Mirabilio, A., Petruccelli, G., Cacchio, M., Ilio, C. D., Loreto, S. D., & Amicarelli, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031401 · Cited by 49 · see citing works

Brain-derived neurotrophic factor and exercise in fibromyalgia syndrome patients: a mini review

Nugraha, B., Karst, M., Engeli, S., & Gutenbrunner, C. M. (2011) · Rheumatology International · doi:10.1007/s00296-011-2348-2 · Cited by 48 · see citing works

Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training.

Pala, R., Orhan, C., Tuzcu, M., Şahin, N., Ali, S., Çınar, V., Atalay, M., & Şahin, K. (2016) · PubMed Central · Cited by 47 · see citing works

Does Exercise Make Migraines Worse and Tension Type Headaches Better?

Hindiyeh, N. A., Krusz, J. C., & Cowan, R. P. (2013) · Current Pain and Headache Reports · doi:10.1007/s11916-013-0380-5 · Cited by 45 · see citing works

Early postinjury exercise reverses memory deficits and retards the progression of closed‐head injury in mice

Chen, M., Huang, T., Kuo, Y., Yu, L., Chen, H., & Jen, C. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.241125 · Cited by 37 · see citing works

Can Exercise Make You Smarter, Happier, and Have More Neurons? A Hormetic Perspective

Gradari, S., Pallé, A., McGreevy, K. R., Fontán‐Lozano, Á., & Trejo, J. L. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00093 · Cited by 37 · see citing works

Short‐term running exercise alters DNA methylation patterns in neuronal nitric oxide synthase and brain‐derived neurotrophic factor genes in the mouse hippocampus and reduces anxiety‐like behaviors

Tomiga, Y., Sakai, K., Ra, S.-G., Kusano, M., Ito, A., Uehara, Y., Takahashi, H., Kawanaka, K., Soejima, H., & Higaki, Y. (2021) · The FASEB Journal · doi:10.1096/fj.202100630r · Cited by 25 · see citing works

Systematic Review and Meta-Analysis of Endurance Exercise Training Protocols for Mice

Massett, M. P., Matejka, C., & Kim, H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.782695 · Cited by 35 · see citing works

Late-Onset Running Biphasically Improves Redox Balance, Energy- and Methylglyoxal-Related Status, as well as SIRT1 Expression in Mouse Hippocampus

Falone, S., D'Alessandro, A., Mirabilio, A., Cacchio, M., Ilio, C. D., Loreto, S. D., & Amicarelli, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048334 · Cited by 35 · see citing works

Does brain-derived neurotrophic factor mediate the effects of exercise on memory?

Loprinzi, P. D. (2019) · The Physician and Sportsmedicine · doi:10.1080/00913847.2019.1610255 · Cited by 33 · see citing works

Maternal separation enhances object location memory and prevents exercise-induced MAPK/ERK signalling in adult Sprague–Dawley rats

Makena, N., Bugarith, K., & Russell, V. A. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9298-6 · Cited by 31 · see citing works

Acute exercise induced BDNF-TrkB signalling is intact in the prefrontal cortex of obese, glucose-intolerant male mice

Baranowski, B. J., & MacPherson, R. E. K. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0108 · Cited by 30 · see citing works

Hippocampal Deformations and Entorhinal Cortex Atrophy as an Anatomical Signature of Long-Term Cognitive Impairment: from the MCAO Rat Model to the Stroke Patient

Delattre, C., Bournonville, C., Auger, F., Lopes, R., Delmaire, C., Hénon, H., Mendyk, A., Bombois, S., Devedjian, J.-C., Leys, D., et al. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0576-9 · Cited by 29 · see citing works

Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice

Kim, D. H., Lee, Y., Lee, H. E., Park, S. J., Jeon, S. J., Jeon, S. J., Cheong, J. H., Shin, C. Y., Son, K. H., & Ryu, J. H. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.09.001 · Cited by 26 · see citing works

Chronic treadmill running protects hippocampal neurons from hypobaric hypoxia-induced apoptosis in rats

Lin, C., Wu, C.-J., Wei, I., Tsai, M.-H., Chang, N.-W., Yang, T., & Kuo, Y. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.051 · Cited by 25 · see citing works

Exercise increases information content and affects long-term stability of hippocampal place codes

Rechavi, Y., Rubin, A., Yizhar, O., & Ziv, Y. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111695 · Cited by 24 · see citing works

Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum

Huang, T.-Y., Lin, L.-S., Cho, K.-C., Chen, S.-J., Kuo, Y., Yu, L., Wu, F., Chuang, J., Chen, H., & Jen, C. J. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01363.2011 · Cited by 24 · see citing works

The impact of the frequency of moderate exercise on memory and brain-derived neurotrophic factor signaling in young adult and middle-aged rats

da Costa, M. S., Ardais, A. P., Fioreze, G. T., Mioranzza, S., Botton, P. H. S., Souza, D. O., da Rocha, J. B. T., & Porciúncula, L. O. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.068 · Cited by 21 · see citing works

Age-dependent differences of treadmill exercise on spatial learning ability between young- and adult-age rats

Jin, J., Ko, I., Kim, S., Hwang, L., Lee, M.-G., Kim, D.-Y., & Jung, S.-Y. (2017) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1735070.535 · Cited by 22 · see citing works

Aberrant expression of synaptic plasticity‐related genes in the NF1+/− mouse hippocampus

Park, C. S., Zhong, L., & Tang, S. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22134 · Cited by 18 · see citing works

Exercise prevents downregulation of hippocampal presynaptic proteins following olanzapine-elicited metabolic dysregulation in rats: distinct roles of inhibitory and excitatory terminals.

Ramos-Miguel, A., Honer, W. G., Boyda, H. N., Sawada, K., Beasley, C. L., Procyshyn, R. M., & Barr, A. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.022 · Cited by 18 · see citing works

Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits

Wang, T.-F., Wu, S.-Y., Pan, B., Tsai, S., & Kuo, Y. (2022) · Cells · doi:10.3390/cells11030481 · Cited by 18 · see citing works

The Role of Contingency and Contiguity in Young and Older Adults' Causal Learning

Mutter, S. A., DeCaro, M. S., & Plumlee, L. F. (2009) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbp004 · Cited by 18 · see citing works

Aerobic exercise training improves memory function through modulation of brain-derived neurotrophic factor and synaptic proteins in the hippocampus and prefrontal cortex of type 2 diabetic rats

Sadri, I., Nikookheslat, S. D., Karimi, P., Khani, M., & Nadimi, S. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01360-9 · Cited by 17 · see citing works

Age- and sex-related analysis of methylation of 5′-upstream sequences of Fmr-1 gene in mouse brain and modulation by sex steroid hormones

Singh, K., & Prasad, S. (2008) · Biogerontology · doi:10.1007/s10522-008-9178-y · Cited by 17 · see citing works

The endocannabinoid system regulates the moderate exercise-induced enhancement of learning and memory in mice

Wang, H., & Han, J. (2020) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.19.10235-6 · Cited by 16 · see citing works

Brain-derived Neurotrophic Factor Pathway after Downhill and Uphill Training in Rats

Pédard, M., Cefis, M., Ennequin, G., Quirié, A., Garnier, P. E., Prigent‐Tessier, A., Pernet, N., & Marie, C. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001771 · Cited by 15 · see citing works

Can the tyrosine kinase inhibitors trigger metabolic encephalopathy in cirrhotic patients?

Brandi, G., Rosa, F. D., Calzà, L., Girolamo, S. D., Tufoni, M., Ricci, C. S., Cirignotta, F., Caraceni, P., & Biasco, G. (2012) · Liver International · doi:10.1111/liv.12102 · Cited by 15 · see citing works

Mechanisms and benefits of cardiac rehabilitation in individuals with stroke: emerging role of its impact on improving cardiovascular and neurovascular health

Cuccurullo, S. J., Fleming, T. K., Petrosyan, H. A., Hanley, D. F., & Raghavan, P. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1376616 · Cited by 14 · see citing works

Effect of thyroxine on synaptotagmin 1 and SNAP-25 expression in dorsal hippocampus of adult-onset hypothyroid rats

Liu, C. L., Xu, Y. X., Zhan, Y., Haitao, H., Jia, X., Chen, G. H., & Zhu, D.-F. (2010) · Journal of Endocrinological Investigation · doi:10.1007/bf03347086 · Cited by 14 · see citing works

Marine phytoplankton improves recovery and sustains immune function in humans and lowers proinflammatory immunoregulatory cytokines in a rat model

Sharp, M. H., Wilson, J. M., Stefan, M. W., Gheith, R. H., Lowery, R. P., Ottinger, C., Reber, D. D., Orhan, C., Şahin, N., Tuzcu, M., et al. (2021) · Physical Activity and Nutrition · doi:10.20463/pan.2021.0007 · Cited by 13 · see citing works

Resistance Training Modulates Hippocampal Neuroinflammation and Protects Anxiety-Depression-like Dyad Induced by an Emotional Single Prolonged Stress Model

Jung, J. T. K., Marques, L. S., Zborowski, V. A., Silva, G. L., Nogueira, C. W., & Zeni, G. R. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03069-x · Cited by 13 · see citing works

Trends in exercise neuroscience: raising demand for brain fitness

Lee, M. C., Byun, K., Kim, J., Lee, H., & Kim, K.-J. (2019) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1938046.023 · Cited by 14 · see citing works

Phytoplankton Supplementation Lowers Muscle Damage and Sustains Performance across Repeated Exercise Bouts in Humans and Improves Antioxidant Capacity in a Mechanistic Animal

Sharp, M. H., Şahin, K., Stefan, M. W., Orhan, C., Gheith, R. H., Reber, D. D., Şahin, N., Tuzcu, M., Lowery, R. P., Durkee, S., et al. (2020) · Nutrients · doi:10.3390/nu12071990 · Cited by 13 · see citing works

Effect of Exercise Training on Hippocampal Volume in Humans

Parker, B. A., Thompson, P. D., Jordan, K. C., Grimaldi, A. S., Assaf, M., Jagannathan, K., & Pearlson, G. D. (2011) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2011.10599793 · Cited by 13 · see citing works

The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF‐α, and MMP2 Genes in Rats with Stroke

Kheravi, M. T., Nayebifar, S., Aletaha, S. M., & Sarhadi, S. (2021) · BioMed Research International · doi:10.1155/2021/5595368 · Cited by 12 · see citing works

Enhancing Neuroprotection Through Exercise: The Synergistic Effects of Bioactive Plant Compounds Via the CREB-BDNF Signaling Pathway

Li, J., Sun, L., Fang, F., & Morshedi, M. M. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10228-z · Cited by 10 · see citing works

Excessive Treadmill Training Enhances Brain-Specific MicroRNA-34a in the Mouse Hippocampus

Lin, X., Zheng, Y., Yin, X., Xu, S. J., Dong, T., Zhang, C. Y., Wang, S., & Zheng, J. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00007 · Cited by 10 · see citing works

Accelerated Fear Extinction by Regular Light-Intensity Exercise: A Possible Role of Hippocampal BDNF-TrkB Signaling

SHIMODA, R., AMAYA, Y., Okamoto, M., Soya, S., Soya, M., Koizumi, H., NAKAMURA, K., Hiraga, T., Torma, F., & Soya, H. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003312 · Cited by 9 · see citing works

Effect of thyroxine on munc-18 and syntaxin-1 expression in dorsal hippocampus of adult-onset hypothyroid rats

Zhu, Y., Ning, D., Wang, F., Liu, C., Xu, Y., Jia, X., & Zhu, D. (2012) · European Journal of Histochemistry · doi:10.4081/ejh.2012.22 · Cited by 9 · see citing works

Alterations in MicroRNA-132/212 Expression Impairs Fear Memory in Goldfish Carassius auratus

Thangaleela, S., Shanmugapriya, V., Mukilan, M., Radhakrishnan, K., & Rajan, K. E. (2018) · Annals of Neurosciences · doi:10.1159/000486842 · Cited by 5 · see citing works

Marine Phytoplankton Improves Exercise Recovery in Humans and Activates Repair Mechanisms in Rats

Sharp, M. H., Şahin, K., Stefan, M., Gheith, R. H., Reber, D. D., Ottinger, C., Orhan, C., Tuzcu, M., Şahin, N., Lowery, R. P., et al. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1320-1061 · Cited by 3 · see citing works

Endurance Exercise Training Attenuates the Waterpipe Smoke Inhaling-Induced Learning and Memory Impairment in Rats: Role of Neurotrophic Factors and Apoptotic System

Taghipour, M., Joukar, S., Alavi, S. S., Mohammadi, F., Asadi‐Shekaari, M., & Alibolandi, Z. (2023) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntad101 · Cited by 3 · see citing works

Hippocampal delta oscillations entrain neuronal activity, modulate gamma amplitude and convey information about running speed on a treadmillPreprint

Furtunato, A. M. B., Pedrosa, R., Soares, B. L., Tort, A. B. L., & Belchior, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.24.477542 · Cited by 3 · see citing works

Physical Exercise Benefits Cognition: A Narrative Review of Evidence and Possible Mechanisms

Wang, T.-F., Mee-inta, O., & Kuo, Y. (2025) · Advances in neurobiology · doi:10.1007/978-981-95-0066-6_7 · Cited by 2 · see citing works

Remembering how to run: A descriptive wheel run analysis in CF1 male and female mice

Santos, M. J., Picco, S., Fernández, R. S., Pedreira, M. E., Boccia, M. M., Klappenbach, M., & Krawczyk, M. C. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.04.003 · Cited by 2 · see citing works

Effects of Exercise on Basal Ganglia Function in Parkinson's Disease and Its Animal Models

Petzinger, G. M., Fisher, B. E., Meshul, C. K., Walsh, J. P., Akopian, G. K., & Jakowec, M. W. (2011) · Parkinson s Disease · doi:10.1002/9781444397970.ch37 · Cited by 2 · see citing works

The role of exercise on cognitive processes and neuroplasticity

Djuric, E., Škrijelj, D., & Rašić-Marković, A. (2018) · Medicinski podmladak · doi:10.5937/mp69-18134 · Cited by 1 · see citing works

A Functional Genomic Analysis of NF1-Associated Learning Disabilities

Tang, S.-J. (2005) · doi:10.21236/ada435850

The rewarding and cognitive effects of corticosterone in mice

Ebada, M. E. (2012) · Nottingham ePrints (University of Nottingham)

Use it and boost it: Cognitive and physical activities modulate cognition via BDNF-TrkB signaling

Scavuzzo, C. J. (2014) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety

Oliveira, K. S., Hounie, A. G., Cappi, C., & Diniz, J. B. (2016) · Jornal Brasileiro de Psiquiatria · doi:10.1590/0047-2085000000132

Effects of exercise on neuroprotection in experimental autoimmune encephalomyelitis

Pryor, W. M. (2012)

Effect of Aerobic Training on Synaptic Integrity Proteins in Hippocampus and Prefrontal Cortex of Type II Diabetic Rats

Nikookheslat, S. D., Karimi, P., & Sadri, I. (2020) · Medical Journal of Tabriz University of Medical Sciences and Health Services · doi:10.34172/mj.2020.032

Exercise training improves adipocyte accumulation and muscle fibrosis by TGF-β1 and α-SMA reduction after botulinum toxin type A administration in micePreprint

Na, J., Lee, E., Im, S. I., Kim, Y., Kim, S., & Kim, B. J. (2020) · doi:10.21203/rs.3.rs-17126/v4

Exercise training improves adipocyte accumulation and muscle fibrosis by TGF-β1 and α-SMA reduction after botulinum toxin type A administration in micePreprint

Na, J., Lee, E., Im, S. I., Kim, Y., Kim, S., & Kim, B. J. (2020) · doi:10.21203/rs.3.rs-17126/v3

Exercise training improves adipocyte accumulation and muscle fibrosis by TGF-β1 and α-SMA reduction after botulinum toxin type A administration in micePreprint

Na, J., Lee, E., Im, S. I., Kim, Y., Kim, S., & Kim, B. J. (2020) · doi:10.21203/rs.3.rs-17126/v2

Approches physiopathologiques des interactions entre accident vasculaire cérébral et démence vasculaire

Delattre, C. (2013) · doi:10.70675/721eacdez23e3z4347zafcaz96d2d090a715

Impact des modalités d'un exercice physique sur la neuroplasticité. Focus sur les sources de BDNF

Cefis, M. (2019) · theses.fr (ABES) · doi:10.70675/a291eab2z851ez4270za4b1z059b856a5aa1

Differential effects of cannabidiol on inhibitory avoidance memory reconsolidation and consolidation are associated with distinct hippocampal proBDNF and BDNF signaling profiles

Dai, W., Huang, W.-L., & Hu, S. S. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1915561

Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I

Liu, Y., Chen, H., Wu, C., Kuo, Y., Yu, L., Huang, A., Wu, F., Chuang, J., & Jen, C. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173088 · Cited by 199 · see citing works

Treadmill exercise, but not voluntary wheel running, facilitates aversive learning and memory

Jen, C. J. (2008) · Frontiers in Human Neuroscience · doi:10.3389/conf.neuro.09.2009.01.242

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition

Vaynman, S., Ying, Z., & Gomez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03720.x · Cited by 1,460 · see citing works

Effects of Treadmill Exercise on Hippocampal Synaptic Plasticity and Expression of Related Proteins in Aging Mice

Sinuo, W. A. N. G., Yajun, C. A. O., Xiang, Q., Yan, J., Yanting, L. I. N., ZHUANG, Y., Guo, X., & Weilin, L. I. U. (2023) · Rehabilitation Medicine · doi:10.3724/sp.j.1329.2023.03007

Influences of Exercise Training on Signaling Molecules Cascaded Long-term Potentiation in Hippocampus

Li, Z. (2007) · Sport Science and Technology