HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner
Open accessAbstract
Transcription of genes required for long-term memory not only involves transcription factors, but also enzymatic protein complexes that modify chromatin structure. Chromatin-modifying enzymes, such as the histone acetyltransferase (HAT) CREB (cyclic-AMP response element binding) binding protein (CBP), are pivotal for the transcriptional regulation required for long-term memory. Several studies have shown that CBP and histone acetylation are necessary for hippocampus-dependent long-term memory and hippocampal long-term potentiation (LTP). Importantly, every genetically modified Cbp mutant mouse exhibits long-term memory impairments in object recognition. However, the role of the hippocampus in object recognition is controversial. To better understand how chromatin-modifying enzymes modulate long-term memory for object recognition, we first examined the role of the hippocampus in retrieval of long-term memory for object recognition or object location. Muscimol inactivation of the dorsal hippocampus prior to retrieval had no effect on long-term memory for object recognition, but completely blocked long-term memory for object location. This was consistent with experiments showing that muscimol inactivation of the hippocampus had no effect on long-term memory for the object itself, supporting the idea that the hippocampus encodes spatial information about an object (such as location or context), whereas cortical areas (such as the perirhinal or insular cortex) encode information about the object itself. Using location-dependent object recognition tasks that engage the hippocampus, we demonstrate that CBP is essential for the modulation of long-term memory via HDAC inhibition. Together, these results indicate that HDAC inhibition modulates memory in the hippocampus via CBP and that different brain regions utilize different chromatin-modifying enzymes to regulate learning and memory.
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Pre-test muscimol microinjections into the dorsal hippocampus impaired or did not affect NOP memory in mice.
“Pre-test muscimol microinjections into the dorsal hippocampus was reported to impair (Cohen et al., 2013; Stackman et al., 2016) or not affect (Haettig et al., 2011) NOP memory in mice.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Haettig et al., 2011
Post-sample intra-hippocampus infusion of muscimol impaired long-term NOP (24 hours) memory.
“Post-sample intra-hippocampus infusion of muscimol impaired long-term NOP (24 hours) memory (Cohen et al., 2013; Haettig et al., 2011), but see (Oliveira et al., 2010).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Haettig et al., 2011
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Epigenetic Mechanisms of Rubinstein–Taybi Syndrome
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Epigenetic regulation of estrogen-dependent memory
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Epigenetic Mechanisms in Experience-Driven Memory Formation and Behavior
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Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss
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Sharma, B., & Sharma, P. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.07.017 · Cited by 59 · see citing works
Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Manner
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Pérez-García, G., Guzmán‐Quevedo, O., Aragão, R. D. S., & Bolaños‐Jiménez, F. (2016) · Scientific Reports · doi:10.1038/srep21275 · Cited by 58 · see citing works
Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice
Seese, R. R., Wang, K., Yao, Y. Q., Lynch, G., & Gall, C. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413335111 · Cited by 52 · see citing works
Postsynaptic GABABReceptor Activity Regulates Excitatory Neuronal Architecture and Spatial Memory
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Anterior retrosplenial cortex is required for long-term object recognition memory
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Jarome, T. J., Perez, G., Webb, W. M., Hatch, K. M., Navabpour, S., Musaus, M., Farrell, K., Hauser, R. M., McFadden, T., Martin, K., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.029 · Cited by 52 · see citing works
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Age-associated gut microbiota impairs hippocampus-dependent memory in a vagus-dependent manner
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Koss, W. A., & Frick, K. M. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.01.002 · Cited by 47 · see citing works
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FGF-23 Deficiency Impairs Hippocampal-Dependent Cognitive Function
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From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health
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Li, D., Jing, D., Liu, Z., Chen, Y., Huang, F., & Behnisch, T. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00133 · Cited by 43 · see citing works
Beldjoud, H., Barsegyan, A., & Roozendaal, B. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00108 · Cited by 42 · see citing works
Novelty and Novel Objects Increase c-Fos Immunoreactivity in Mossy Cells in the Mouse Dentate Gyrus
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Therapeutic Potential of Isoform Selective Hdac Inhibitors for the Treatment of Schizophrenia
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Critical aspects of neurodevelopment
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Epigenetic Factors in Intellectual Disability
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Epigenetic contributions to cognitive aging: disentangling mindspan and lifespanPreprint
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TIP60 in aging and neurodegeneration
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Epigenetics, Oestradiol and Hippocampal Memory Consolidation
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Aging mice show impaired memory updating in the novel OUL updating paradigm
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HDAC Inhibition Facilitates the Switch between Memory Systems in Young But Not Aged Mice
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Epigenetic Regulation of the Molecular Clockwork
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New innovations: Therapeutic opportunities for intellectual disabilities
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Alaghband, Y., Kwapis, J. L., López, A. J., White, A. O., Aimiuwu, O. V., Al-Kachak, A., Bodinayake, K. K., Oparaugo, N. C., Dang, R., Astarabadi, M., et al. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.09.001 · Cited by 34 · see citing works
- Authors
- Haettig, J., Stefanko, D. P., Multani, M. L., Figueroa, D. X., McQuown, S. C., & Wood, M. A.
- Affiliations
- University of California, Irvine (US)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-01-11
- Volume
- 18
- Issue
- 2
- Pages
- 71-79
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC3032579
- OpenAlex
- W2159726740
- Cited by
- 211
- References
- 38
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 15 · 2021: 12 · 2020: 16 · 2019: 20 · 2018: 12 · 2017: 18 · 2016: 21 · 2015: 9 · 2014: 21 · 2013: 25 · 2012: 13
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Whitehall Foundation
- National Institute of Mental Health (R01MH081004)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- histone deacetylase inhibition, CBP, CREB-binding protein, hippocampal-dependent memory, object location memory, object recognition memory, long-term memory, chromatin modification, histone acetylation, muscimol inactivation, spatial memory, memory retrieval, hippocampal long-term potentiation
- MeSH terms
- Animals, Hippocampus, Histone Deacetylases, Immunohistochemistry, Learning, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Muscimol, CREB-Binding Protein, Mice, Gene Knock-In Techniques, Histone Deacetylase Inhibitors, Memory, Long-Term, GABA-A Receptor Agonists
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