The level of arabinitol in autistic children after probiotic therapy
Abstract
Objective The level of D-arabinitol (DA) and the ratio of D-/L-arabinitol (DA/LA) in the urine of children with autism were investigated. The changes in DA/LA after probiotic treatment in urine samples of children with autism were studied.Methods DA and LA and the DA/LA ratio were identified by capillary gas chromatography/mass spectrometry in urine before and after the probiotic therapy.Results The level of DA is significantly higher (P < 0.05) in the urine of autistic children before (A) and after probiotic supplementation (A1) (160.04 ± 22.88 μmol/mmol creatinine and 89.53 ± 37.41 μmol/mmol creatinine, respectively). Nonetheless, the probiotic supplementation let to a significant decrease in DA and DA/LA and to a significant improvement in ability of concentration and carrying out orders.Conclusion The use of probiotics seems to be helpful in reducing the level of DA and the ratio of DA/LA in the urine of children with autism.
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A preliminary study of 22 children with ASD and GI dysfunction found that D-arabinitol concentrations and D-arabinitol/L-arabinitol ratios were significantly reduced with daily probiotics, and improvements were seen in certain ASD behaviors including ability to concentrate.
“A preliminary study of 22 children with ASD and GI dysfunction found that DA concentrations and DA/LA ratios were significantly reduced with daily administration of probiotics, and improvements were seen in certain ASD behaviors including ability to concentrate [62].”
From The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders (2018) · cites this paper as [62]
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- Authors
- Kałużna-Czaplińska, J., & Błaszczyk, S.
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 28
- Issue
- 2
- Pages
- 124-126
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W2036673372
- Cited by
- 189
- References
- 28
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 10 · 2023: 12 · 2022: 32 · 2021: 24 · 2020: 24 · 2019: 14 · 2018: 19 · 2017: 8 · 2016: 11 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science (NN 204 316234)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- autism spectrum disorder, probiotics, D-arabinitol, urinary metabolites, children, probiotic supplementation, attention and executive function
- MeSH terms
- Attention, Autistic Disorder, Candidiasis, Child, Child Behavior, Child, Preschool, Female, Humans, Isomerism, Male, Gas Chromatography-Mass Spectrometry, Sugar Alcohols, Dietary Supplements, Probiotics
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