Cited by 146Gut microbiota and healthAutism Spectrum Disorder ResearchChild Nutrition and Feeding Issues

Microbiome and nutrition in autism spectrum disorder: Current knowledge and research needs

Berding, Kirsten, Donovan, Sharon M.·2016·Nutrition Reviews

Abstract

Autism spectrum disorder (ASD) is the fastest growing neurodevelopmental disorder in the United States. Besides genetic risks, environmental factors have been suggested to contribute to the increase in ASD diagnosis over the past decade. Several studies have reported abnormalities in microbiota composition and differences in microbial metabolites in children with ASD. Gastrointestinal discomfort is commonly reported in children with ASD. Additionally, food selectivity and picky eating patterns are commonly reported. A number of mechanisms underlying the interaction between nutrition, the gut microbiota, and ASD symptoms via the microbiota-gut-brain axis have been proposed, including immune, hormonal, or neuronal pathways. Here, the current evidence base regarding the gut environment and nutritional status of children with ASD is reviewed. Potential underlying mechanisms of the microbiota-gut-brain axis in ASD and the interplay between nutrition, microbiota, and ASD symptoms are also reviewed. Future studies investigating the microbiota in the context of dietary intake are needed to increase understanding of the interplay between diet and the gut microbiota in ASD and to identify potential dietary, probiotic, or prebiotic intervention strategies.

Integrity signals

Registry

Crossref · 10.1093/nutrit/nuw048

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171 of 171 references verified0 citation errors · 0 not checkable

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  • The gut microbiome communicates with brain activities through microbiota-derived signaling molecules, immune mediators, gut hormones, and vagal and spinal afferent neurons.

    “Recent evidences in human gut microbiota studies highlighted the existence of a close connection between gut and brain functions, the so called “gut-brain axis”, including neural, hormonal, immune, and metabolic pathways [45].”

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Authors
Berding, K., & Donovan, S. M.
Affiliations
University of Illinois Urbana-Champaign (US)
Venue
Nutrition Reviews
Published
2016-11-17
Volume
74
Issue
12
Pages
723-736
ISSN
  • 0029-6643 (ISSN-L)
  • 1753-4887
OpenAlex
W2550666039
Cited by
146
References
171
Citations by year
2026: 3 · 2025: 15 · 2024: 17 · 2023: 21 · 2022: 10 · 2021: 25 · 2020: 14 · 2019: 18 · 2018: 14 · 2017: 9
FWCI
1.22
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords
autism spectrum disorder, gut microbiota, microbiota-gut-brain axis, nutrition, dietary intake, picky eating, gastrointestinal symptoms, microbial metabolites, probiotics, prebiotics
MeSH terms
Autism Spectrum Disorder, Gastrointestinal Microbiome, Brain, Diet, Humans, Nutritional Status, Probiotics, Prebiotics, Microbiota

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