Microbiome and nutrition in autism spectrum disorder: Current knowledge and research needs
Abstract
Autism spectrum disorder (ASD) is the fastest growing neurodevelopmental disorder in the United States. Besides genetic risks, environmental factors have been suggested to contribute to the increase in ASD diagnosis over the past decade. Several studies have reported abnormalities in microbiota composition and differences in microbial metabolites in children with ASD. Gastrointestinal discomfort is commonly reported in children with ASD. Additionally, food selectivity and picky eating patterns are commonly reported. A number of mechanisms underlying the interaction between nutrition, the gut microbiota, and ASD symptoms via the microbiota-gut-brain axis have been proposed, including immune, hormonal, or neuronal pathways. Here, the current evidence base regarding the gut environment and nutritional status of children with ASD is reviewed. Potential underlying mechanisms of the microbiota-gut-brain axis in ASD and the interplay between nutrition, microbiota, and ASD symptoms are also reviewed. Future studies investigating the microbiota in the context of dietary intake are needed to increase understanding of the interplay between diet and the gut microbiota in ASD and to identify potential dietary, probiotic, or prebiotic intervention strategies.
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The gut microbiome communicates with brain activities through microbiota-derived signaling molecules, immune mediators, gut hormones, and vagal and spinal afferent neurons.
“Recent evidences in human gut microbiota studies highlighted the existence of a close connection between gut and brain functions, the so called “gut-brain axis”, including neural, hormonal, immune, and metabolic pathways [45].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [45]
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The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857 · see citing works
The contribution of environmental exposure to the etiology of autism spectrum disorder
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The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder
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Cross talk: the microbiota and neurodevelopmental disorders
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One health, fermented foods and gut microbiota
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Self-citationDietary Interventions for Autism Spectrum Disorder: A Meta-analysis
Fraguas, D., Díaz-Caneja, C. M., Pina-Camacho, L., Moreno, C., Durán-Cutilla, M., Ayora, M., González-Vioque, E., de Matteis, M., Hendren, R. L., Arango, C., et al. (2019) · PEDIATRICS · doi:10.1542/peds.2018-3218 · Cited by 80 · see citing works
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Narrative review on potential role of gut microbiota in certain substance addiction
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The role of host molecules in communication with the resident and pathogenic microbiota: A review
White, J. R., Dauros-Singorenko, P., Hong, J., Vanholsbeeck, F., Phillips, A., & Swift, S. (2020) · Medicine in Microecology · doi:10.1016/j.medmic.2020.100005 · Cited by 21 · see citing works
- Authors
- Berding, K., & Donovan, S. M.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-11-17
- Volume
- 74
- Issue
- 12
- Pages
- 723-736
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2550666039
- Cited by
- 146
- References
- 171
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 17 · 2023: 21 · 2022: 10 · 2021: 25 · 2020: 14 · 2019: 18 · 2018: 14 · 2017: 9
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, gut microbiota, microbiota-gut-brain axis, nutrition, dietary intake, picky eating, gastrointestinal symptoms, microbial metabolites, probiotics, prebiotics
- MeSH terms
- Autism Spectrum Disorder, Gastrointestinal Microbiome, Brain, Diet, Humans, Nutritional Status, Probiotics, Prebiotics, Microbiota
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