How important is tryptophan in human health?

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Redox signaling and Alzheimer’s disease: from pathomechanism insights to biomarker discovery and therapy strategy

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Plasma Metabolomics Reveals Systemic Metabolic Alterations of Subclinical and Clinical Hypothyroidism

Shao, F., Li, R., Guo, Q., Qin, R., Su, W., Yin, H., & Tian, L. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac555 · Cited by 32 · see citing works

Comparative Metabolic Profiling in Pulp and Peel of Green and Red Pitayas (Hylocereus polyrhizus and Hylocereus undatus) Reveals Potential Valorization in the Pharmaceutical and Food Industries

Lin, X., Gao, H., Ding, Z., Zhan, R., Zhou, Z., & Ming, J. (2021) · BioMed Research International · doi:10.1155/2021/6546170 · Cited by 31 · see citing works

The Effects of Maternal Interleukin-17A on Social Behavior, Cognitive Function, and Depression-Like Behavior in Mice with Altered Kynurenine Metabolites

Murakami, Y., Imamura, Y., Kasahara, Y., Yoshida, C., Momono, Y., Fang, K., Nishiyama, T., Sakai, D., & Konishi, Y. (2021) · International Journal of Tryptophan Research · doi:10.1177/11786469211026639 · Cited by 31 · see citing works

The Impact of Probiotic Bacillus subtilis on Injurious Behavior in Laying Hens

Jiang, S., Hu, J., & Cheng, H. W. (2022) · Animals · doi:10.3390/ani12070870 · Cited by 29 · see citing works

Advances in the Treatment of Autism Spectrum Disorder: Current and Promising Strategies

Yenkoyan, K. B., Ounanian, Z., Mirumyan, M., Hayrapetyan, L., Zakaryan, N., Sahakyan, R., & Bjørklund, G. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673252910230920151332 · Cited by 31 · see citing works

Characterization of the Phenolic Compounds in Different Plant Parts of Amaranthus cruentus Grown under Cultivated Conditions

Manyelo, T. G., Sebola, N. A., Hassan, Z. M., & Mabelebele, M. (2020) · Molecules · doi:10.3390/molecules25184273 · Cited by 30 · see citing works

Improving sleep disturbances in obesity by nutritional strategies: review of current evidence and practical guide

Castellucci, B., Barrea, L., Laudisio, D., Aprano, S., Pugliese, G., Savastano, S., Colao, A., & Muscogiuri, G. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1851659 · Cited by 28 · see citing works

Recent Advances in Current Uptake Situation, Metabolic and Nutritional Characteristics, Health, and Safety of Dietary Tryptophan

Zhu, H., Yang, X., & Zhao, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06419 · Cited by 28 · see citing works

Associations of different types of dairy intakes with depressive symptoms in adults

Sun, J., Wang, W., & Zhang, D. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.095 · Cited by 27 · see citing works

In Silico Molecular Study of Tryptophan Bitterness

Pizio, A. D., & Nicoli, A. (2020) · Molecules · doi:10.3390/molecules25204623 · Cited by 27 · see citing works

Chronic cereulide exposure causes intestinal inflammation and gut microbiota dysbiosis in mice

Lin, R., Li, D., Xu, Y., Wei, M., Chen, Q., Deng, Y., & Wen, J. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117814 · Cited by 27 · see citing works

Visualizing physiological parameters in cells and tissues using genetically encoded indicators for metabolites

Martín, A. S., Arce‐Molina, R., Aburto, C., Baeza‐Lehnert, F., Barros, L. F., Contreras‐Baeza, Y., Pinilla, A., Ruminot, I., Rauseo, D., & Sandoval, P. Y. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.012 · Cited by 28 · see citing works

A 2-Week Specific Volleyball Training Supported by the Whole Body Cryostimulation Protocol Induced an Increase of Growth Factors and Counteracted Deterioration of Physical Performance

Jaworska, J., Micielska, K., Flis, M., Wnorowski, K., Skrobecki, J., Radzimiński, Ł., Babińska, A., Rodziewicz-Flis, E. A., Lombardi, G., & Ziemann, E. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01711 · Cited by 27 · see citing works

Highly sensitive detection of tryptophan (Trp) in serum based on diazo-reaction coupling with Surface-Enhanced Raman Scattering and colorimetric assay

Fan, M., Lu, D., You, R., Chen, C., Lu, Y., Wu, Y., Shen, H.-Y., & Feng, S. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.04.039 · Cited by 27 · see citing works

Polysaccharides to postbiotics: Nurturing bone health via modulating “gut-immune axis”

Yadav, S., Sapra, L., & Srivastava, R. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134655 · Cited by 27 · see citing works

Selenium content and nutritional quality of Brassica chinensis L enhanced by selenium engineered nanomaterials: The role of surface charge

Wang, C., Liu, X., Chen, F., Yue, L., Cao, X., Li, J., Cheng, B., Wang, Z., & Xing, B. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119582 · Cited by 26 · see citing works

Hydrophobic Amino Acid Tryptophan Shows Promise as a Potential Absorption Enhancer for Oral Delivery of Biopharmaceuticals

Kamei, N., Tamiwa, H., Miyata, M., Haruna, Y., Matsumura, K., Ogino, H., Hirano, S., Higashiyama, K., & Takeda‐Morishita, M. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040182 · Cited by 26 · see citing works

Unraveling the Role of ACE2, the Binding Receptor for SARS-CoV-2, in Inflammatory Bowel Disease

Ferreira‐Duarte, M., Estevinho, M. M., Duarte‐Araújo, M., Magro, F., & Morato, M. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa249 · Cited by 25 · see citing works

Utilizing network pharmacology and experimental validation to explore the potential molecular mechanisms of BanXia-YiYiRen in treating insomnia

Wang, L., Wang, P., Chen, Y., Li, C., Wang, X., Zhang, Y., Li, S., & Yang, M. (2022) · Bioengineered · doi:10.1080/21655979.2022.2026862 · Cited by 25 · see citing works

A feasible and efficient voltammetric sensor based on electropolymerized L-arginine for the detection of L-tryptophan in dietary supplements

Lima, D., Pessôa, C. A., Wohnrath, K., Junior, L. H. M., & Bergamini, M. F. (2022) · Microchemical Journal · doi:10.1016/j.microc.2022.107709 · Cited by 25 · see citing works

Lipopolysaccharide accelerates tryptophan degradation in the ovary and the derivative kynurenine disturbs hormone biosynthesis and reproductive performance

Shen, J., Zhao, W., Cheng, J., Cheng, J., Zhao, L., Dai, C., Fu, Y., Li, B., Chen, Z., Shi, D., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131988 · Cited by 24 · see citing works

γ-[Glu]n-Trp ameliorates anxiety/depression-like behaviors and its anti-inflammatory effect in an animal model of anxiety/depression

Zhu, X., Tao, Q., Sun‐Waterhouse, D., Li, W., Liu, S., & Cui, C. (2019) · Food & Function · doi:10.1039/c9fo01467e · Cited by 24 · see citing works

Immunomodulatory, behavioral, and nutritional response of tryptophan application on poultry

Linh, N. T., Guntoro, B., & Qui, N. H. (2021) · Veterinary World · doi:10.14202/vetworld.2021.2244-2250 · Cited by 24 · see citing works

Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach

Cao, Y., Aquino-Martínez, R., Hutchison, E. R., Allayee, H., Lusis, A. J., & Rey, F. E. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101557 · Cited by 23 · see citing works

Tryptophan and Substance Abuse: Mechanisms and Impact

Davidson, M., Rashidi, N., Hossain, M. K., Raza, A., Nurgali, K., & Apostolopoulos, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032737 · Cited by 23 · see citing works

Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction

Tanaka, M., & Vécsei, L. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02812-z · Cited by 23 · see citing works

Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases

Xing, C., Chen, H., Bi, W., Lei, T., Hang, Z., & Du, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413446 · Cited by 21 · see citing works

Nanodelivery Optimization of IDO1 Inhibitors in Tumor Immunotherapy: Challenges and Strategies

Jiang, K., Wang, Q., Chen, X., Wang, X., Gu, X., Feng, S., Wu, J., Shang, H., Ba, X., Zhang, Y., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s458086 · Cited by 21 · see citing works

The possibilities of using a mixture of PDMS and phosphor in a wide range of industry applications

Rendeiro, R., Jargus, J., Nedoma, J., Martínek, R., & Marques, C. (2024) · Opto-Electronic Advances · doi:10.29026/oea.2024.240133 · Cited by 21 · see citing works

Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications

Gong, P., Wang, J., Long, H., Yang, W., Chen, X., Li, N., Chen, F., Zhang, J., & Guo, Y. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70080 · Cited by 21 · see citing works

A study of the mechanism of small-molecule soybean-protein-derived peptide supplement to promote sleep in a mouse model

Yi, G., Safdar, B., Zhang, Y., Li, Y., & Liu, X. (2020) · RSC Advances · doi:10.1039/d0ra00389a · Cited by 23 · see citing works

Potential roles of gut microbial tryptophan metabolites in the complex pathogenesis of acne vulgaris

Huang, Y., Liu, L., Hao, Z., Chen, L., Yang, Q., Xiong, X., & Deng, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.942027 · Cited by 22 · see citing works

Circadian Rhythms and Sleep Disorders Associated to Major Depressive Disorder: Pathophysiology and Therapeutic Opportunities

Manosso, L. M., Duarte, L. A., Martinello, N. S., de Mathia, G. B., & Réus, G. Z. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273254093231020052002 · Cited by 23 · see citing works

Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

Wang, J., Wu, S., Zhang, J., Li, Y., Wu, Y., & Qi, X. (2023) · BMC Nephrology · doi:10.1186/s12882-023-03410-z · Cited by 20 · see citing works

Mechanisms and Therapeutic Potential of Key Anti-inflammatory Metabiotics: Trans-Vaccenic Acid, Indole-3-Lactic Acid, Thiamine, and Butyric Acid

Muñoz-Olivos, C., Bautista, E., Jose, R.-A. M., Berenice, P.-G., Zacapa, D., & Cortez-Sánchez, J. L. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10475-9 · Cited by 20 · see citing works

3D printed electrochemical sensor and microfluidic system for the detection of L-tryptophan using degradable material

Zhan, T., Zhao, B., Zhou, Z.-F., Chen, Z., Zhang, M., Han, G., Feng, X., & Kraatz, H. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.143331 · Cited by 20 · see citing works

Tryptophan

Volkmar, F. R. (2020) · Springer eBooks · doi:10.1007/978-1-4614-6435-8_1842-3

Tryptophan in health and disease

Comai, S., Bertazzo, A., Brughera, M., & Crotti, S. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.08.005 · Cited by 300 · see citing works

Biochemical and dietary functions of tryptophan and its metabolites in human health

Nayak, B. N., Singh, R. B., & Buttar, H. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819815-5.00003-3 · Cited by 17 · see citing works

Nutritional importance of tryptophan for improving treatment in depression and diabetes

Haleem, D. J. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac042 · Cited by 8 · see citing works

Role of essential amino acid tryptophan in causing sleep disorders and anxiety-depressive disorders

Karnaukhov, V. E., Narodova, E. A., Shnayder, N. A., Народова, В. В., Дмитренко, Д. В., & Nasyrova, R. F. (2022) · Человек и его здоровье · doi:10.21626/vestnik/2022-2/02 · Cited by 3 · see citing works