Probiotic yogurt improves antioxidant status in type 2 diabetic patients
Abstract
Objective Oxidative stress plays a major role in the pathogenesis and progression of diabetes. Among various functional foods with an antioxidant effect, probiotic foods have been reported to repress oxidative stress. The objective of this clinical trial was to assess the effects of probiotic and conventional yogurt on blood glucose and antioxidant status in type 2 diabetic patients.Methods Sixty-four patients with type 2 diabetes mellitus, 30 to 60 y old, were assigned to two groups in this randomized, double-blind, controlled clinical trial. The patients in the intervention group consumed 300 g/d of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and those in the control group consumed 300 g/d of conventional yogurt for 6 wk. Fasting blood samples, 24-h dietary recalls, and anthropometric measurements were collected at the baseline and at the end of the trial.Results Probiotic yogurt significantly decreased fasting blood glucose (P < 0.01) and hemoglobin A1c (P < 0.05) and increased erythrocyte superoxide dismutase and glutathione peroxidase activities and total antioxidant status (P < 0.05) compared with the control group. In addition, the serum malondialdehyde concentration significantly decreased compared with the baseline value in both groups (P < 0.05). No significant changes from baseline were shown in insulin concentration and erythrocyte catalase activity within either group (P > 0.05).Conclusion The consumption of probiotic yogurt improved fasting blood glucose and antioxidant status in type 2 diabetic patients. These results suggest that probiotic yogurt is a promising agent for diabetes management.
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A significant reduction in MDA levels was reported in type 2 diabetic patients after consuming probiotic yogurt.
“Consistent to our findings, a significant reduction in MDA levels was reported in type 2 diabetic patients after consuming probiotic yogurt (Ejtahed et al., 2012).”
From Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial (2016) · cites this paper as Ejtahed et al., 2012
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- Authors
- Ejtahed, H. S., Mohtadi-Nia, J., Homayouni-Rad, A., Niafar, M., Asghari-Jafarabadi, M., & Mofid, V.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 28
- Issue
- 5
- Pages
- 539-543
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W2090393270
- Cited by
- 683
- References
- 42
- Citations by year
- 2026: 24 · 2025: 46 · 2024: 49 · 2023: 61 · 2022: 69 · 2021: 63 · 2020: 64 · 2019: 58 · 2018: 52 · 2017: 49 · 2016: 43 · 2015: 35 · 2014: 32 · 2013: 30 · 2012: 7
- FWCI
- 32.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- probiotic yogurt, type 2 diabetes, antioxidant status, oxidative stress, Lactobacillus acidophilus LA-5, Bifidobacterium animalis subsp. lactis BB-12, fasting blood glucose, HbA1c, erythrocyte superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, functional foods, diabetes management
- MeSH terms
- Adult, Antioxidants, Bifidobacterium, Blood Glucose, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Glutathione Peroxidase, Glycated Hemoglobin, Humans, Insulin, Lactobacillus acidophilus, Male, Malondialdehyde, Middle Aged, Superoxide Dismutase, Yogurt, Oxidative Stress, Probiotics
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