Evidences of a new psychobiotic formulation on body composition and anxiety
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Background. Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation.Methods. Eligible patients were randomly divided into three groups: psychobiotics oral suspension group (POSG); dietary treatment group (DTG); combined treatment group (CTG). All subjects underwent body composition and psychological profile evaluation.Results. Significant changes in body composition parameters in each group were relieved after all treatments. Hamilton anxiety rating scale (HAM-A) highlighted a significant reduction of the total score for all study population after treatments in POSG ( p=0.01 ) and CTG ( p=0.04 ). A reduction of HAM-A total score in anxious subjects in POSG or CTG and a significant reduction of positive subjects for HAM-A in POSG ( p=0.03 ) and in CDG ( p=0.01 ) were shown.Discussion. Three-week intake of selected POS represents a good approach to solve problems related to obesity and behavior disorders. However, new clinical trials need to be performed on a larger population and for a longer period of treatment before definitive conclusions can be made. This trial is registered with NCT01890070 .
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A combined dietary-probiotic approach led to a greater reduction in anxiety symptoms, as measured by the Hamilton Anxiety Rating Scale, than each intervention alone in a small-scale study.
“Indeed, a combined dietary-probiotic approach led to a greater reduction in anxiety symptoms, as measured by the Hamilton Anxiety Rating Scale, than each intervention alone in a small-scale study (512).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [512]
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Mental Disorders Linked to Crosstalk between The Gut Microbiome and The Brain
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- Authors
- Colica, C., Avolio, E., Bollero, P., Costa de Miranda, R., Ferraro, S., Sinibaldi Salimei, P., De Lorenzo, A., & Di Renzo, L.
- Affiliations
- Magna Graecia University (IT)
- University of Calabria (IT)
- University of Rome Tor Vergata (IT)
- PhD School of Medical-Surgical Applied Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
- Health Center Srl, Biomedical and Nutritional Center, 87100 Cosenza, Italy
- Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-10
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC5632987
- OpenAlex
- W2760136109
- Cited by
- 63
- References
- 68
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 6 · 2020: 11 · 2019: 9 · 2018: 3
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Agriculture, Food and Forestry (2017188 03/24/2011)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- psychobiotics, gut microbiota, body composition, anxiety, obesity, dietary therapy, combination therapy, oral suspension, Hamilton Anxiety Rating Scale
- MeSH terms
- Adult, Aged, Anthropometry, Anxiety, Body Composition, Female, Humans, Male, Middle Aged, Prospective Studies, Absorptiometry, Photon, Treatment Outcome, Probiotics, Young Adult
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